EP0266580A2
Expired / Lapsed
EP
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A method for coating solid particles with a hydrophilic gel and particles coated by the method
Assignee: Excorim KB
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Filing: 1987-10-12
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Granted: —
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Expires: 2007-10-12
Abstract
Abstract A method for coating solid particles with a hydrophilic gel, characterized in that as the said particles hydrophilic particles are chosen which are mixed with a gel-forming substance at a temperature which is above the gelling temperature. The gel-forming substance is made to cover each individual particle, whereafter the particles are separated from each other and cooled to a temperature which is below the gelling temperature. The invention also relates to particles coated in the above-mentioned manner. The gel-coated particles so obtained either may be used as such in various separating processes, e g as ion exchanger, if the gel-forming substance contains charged groups. Alternatively the gel-coated particles subsequently may be provided with suitable adsorbent groups, e g ion exchange groups, hydrophobic groups or groups with biospecificity. Examples of such groups are enzyme inhibitors, enzymes, antibodies and protein A from staphylococcus Aureus.
Inventors
- 👤 Per-Olof Larsson
- 👤 Kersti Barbro Johnson
- 👤 Ulf Thomas Gustav Nylén
- 👤 Per Ingvar Oskar Wikström
- 👤 Ingrid Kristina Zetterstrand
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-07 19:51
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/30; B01J20/32; B01J20/3231; B01J20/3242; B01J20/3268; B01J20/328; B01J20/3272; B01J20/3274; B01J20/3282; B01J20/3291; B01J20/3293; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/544; G01N33/548
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
68 words
A method for coating solid particles with a hydrophilic gel, characterized in that as the said particles hydrophilic particles are chosen which are so mixed with a gel-forming substance at a temperature, which is above the gelling temperature, that the gel-forming substance is made to cover each individual particle, whereupon the particles are separated from each other and cooled to a temperature which is below the gelling temperature.
Claim 2
Independent Claim
68 words
A method for coating solid particles with a hydrophilic gel, characterized in that as the said particles hydrophilic particles are chosen which are so mixed with a gel-forming substance at a temperature, which is above the gelling temperature, that the gel-forming substance is made to cover each individual particle, whereupon the particles are separated from each other and cooled to a temperature which is below the gelling temperature.
Claim 3
Dependent Claim
27 words
A method in accordance with claim 1, characterized in that the separation takes place by dispersing the coated particles in a hydrophobic solvent which subsequently is cooled.
Claim 4
Dependent Claim
21 words
A method in accordance with claim 2, characterized in that the dispersion is facilitated through the addition of a dispersing agent.
Claim 5
Dependent Claim
31 words
A method in accordance with claim 2 and 3, characterized in that the particles, the gel and the said hydrophobic solvent are selected so that their density is substantially the same.
Claim 6
Dependent Claim
41 words
A method in accordance with claim 2 and 3 using particles and/or gel of a density other, in particular higher, than that of the hydrophobic solvent, characterized in that as the said hydrophobic solvent one of a high viscosity is selected.
Claim 7
Independent Claim
20 words
A method in accordance with anyone of claims 2-5, characterized in that the mixing takes place in the hydrophobic solvent.
Claim 8
Independent Claim
29 words
A method in accordance with anyone of claims 2-5, characterized in that the particles are mixed with the gel-forming substance before the mixture is dispersed in the hydrophobic solvent.
Claim 9
Dependent Claim
53 words
A method in accordance with claim 1, characterized in that the separation is brought about mechanically in that the particles mixed with the gel are forced through a sieve or the like of such a mesh size that only one coated particle at a time can pass the respective holes in the same.
Claim 10
Dependent Claim
34 words
A method in accordance with claim 8, characterized in that the separated particles are allowed to drop down freely from the sieve into cold air, a cold gas or another cooling agent and/or solvent.
Claim 11
Dependent Claim
24 words
A method in accordance with claim 9, characterized in that the said cooling agent consists of water of a temperature below the gelling temperature.
Claim 12
Dependent Claim
18 words
A method in accordance with claim 9, characterized in that the said solvent consists of a hydrophobic one.
Claim 13
Dependent Claim
29 words
A method in accordance with claim 11, characterized in that the surface temperature of the hydrophobic solvent exceeds the gelling temperature whilst its bottom temperature is below the same.
Claim 14
Independent Claim
22 words
A method in accordance with anyone of the preceding claims, characterized in that as the said particles hydrophilic glass particles are chosen.
Claim 15
Independent Claim
45 words
A method in accordance with anyone of claims 1-12, characterized in that as the material for the said particles one from the group of PVC, polyamide, acrylate, methylmethacrylate, polystyrene and polycarbonate is chosen, the particles being pretreated first so as to produce a hydrophilic surface.
Claim 16
Independent Claim
29 words
A method in accordance with anyone of the preceding claims, characterized in that the particle size is chosen between 0.001 and 5 mm, preferably between 0.15 and 1 mm.
Claim 17
Independent Claim
32 words
A method in accordance with anyone of the preceding claims, characterized in that as the gel one within the group of agarose, agar, cappa carrageenan, starch and chitosan, preferably agarose, is chosen.
Claim 18
Dependent Claim
29 words
A method in accordance with claim 16, characterized in that for the gel layer a thickness between 0.0001 and 1.0 mm, preferably between 0.001 and 0.05 mm is chosen.
Claim 19
Independent Claim
29 words
A method in accordance with anyone of the preceding claims, characterized in that the particles with gel layer are washed so as to be strengthened thereafter, preferably through cross-linkage.
Claim 20
Independent Claim
43 words
A method in accordance with anyone of the preceding claims, characterized in that adsorbent units are bonded chemically to the gel, e g ion exchange groups, hydrophobic groups or groups units with biospecificity, e g enzyme inhibitors, enzymes, antigens, protein A or antibodies.
Claim 21
Dependent Claim
19 words
Coated particles, characterized in that they are manufactured in accordance with the method of anyone of the preceding claims.
References Cited (Backward Citations)
No citation records indexed.
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