EP0262890A2
Expired / Lapsed
EP
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Heparin-containing adhesion prevention barrier and process
Assignee: Ethicon Inc
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Filing: 1987-09-28
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Granted: —
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Expires: 2007-09-28
Abstract
Abstract An improved adhesion-preventative barrier fabric comprising an oxidized regenerated cellulose (ORC) fabric (or matrix having equivalent properties) which is drapable, conformable, adherent to body organs, and substantially absorbable within thirty (30) days in the body, which fabric has heparin absorbed thereon, said heparin being present in a non-toxic, adhesion-preventative, effective amount and potency; and, the process of using said improved barrier fabric or matrix to administer heparin to prevent surgical adhesions.
Inventors
- 👤 Cary Bruce Linksy
- 👤 Eli Pines
- 👤 Timothy Joseph Cunningham
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 05:24
CPC Classifications
A; A61; A61L; A61L15/00; A61L33/00; A61L33/0005; A61L33/0011; A61L31/00; A61L31/04; A61L31/042; A61L31/14; A61L31/16; A61L2300/00; A61L2300/20; A61L2300/23; A61L2300/236; A61L2300/40; A61L2300/424
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
47 words
An improved adhesion-preventative barrier fabric comprising an oxidized regenerated cellulose fabric which is drapable, conformable, adherent to body organs, and substantially absorbable within thirty (30) days in the body, which fabric has heparin absorbed thereon, said heparin being present in a non-toxic, adhesion-preventative effective amount and potency.
Claim 2
Dependent Claim
47 words
An improved adhesion-preventative barrier fabric comprising an oxidized regenerated cellulose fabric which is drapable, conformable, adherent to body organs, and substantially absorbable within thirty (30) days in the body, which fabric has heparin absorbed thereon, said heparin being present in a non-toxic, adhesion-preventative effective amount and potency.
Claim 3
Dependent Claim
32 words
The product of claim 1 wherein the heparin absorbed on the fabric is applied to the fabric in liquid form at the time of actual use on a body organ during surgery.
Claim 4
Dependent Claim
16 words
The product of claim 1 wherein the heparin is absorbed on said fabric and subsequently dried.
Claim 5
Dependent Claim
25 words
The product of claim 1 wherein the heparin is absorbed on the fabric, and the heparin-containing fabric is then dried and sealed in sterile form.
Claim 6
Dependent Claim
26 words
The product of claim 1 wherein the amount of heparin utilized is sufficient to saturate the fabric but not so great that any heparin drips off.
Claim 7
Dependent Claim
30 words
The product of any one of claims 1 to 5 wherein the heparin utilized is in the form of Heparin Sodium Injectible having a potency of 100-2000 USP Heparin Units.
Claim 8
Dependent Claim
20 words
The product of any one of claims 1 to 6 wherein the oxidized regenerated cellulose fabric is a knit fabric.
Claim 9
Dependent Claim
51 words
An improved adhesion-preventative barrier material comprising a matrix which is safe for use in surgery and is drapable, conformable, adherent to body organs, and substantially absorbable within thirty (30) days in the body, which matrix has heparin absorbed thereon, said heparin being present in a non-toxic, adhesion-preventative effective amount and potency.
Claim 10
Dependent Claim
51 words
An improved adhesion-preventative barrier material comprising a matrix which is safe for use in surgery and is drapable, conformable, adherent to body organs, and substantially absorbable within thirty (30) days in the body, which matrix has heparin absorbed thereon, said heparin being present in a non-toxic, adhesion-preventative effective amount and potency.
Claim 11
Dependent Claim
49 words
The product of any one of claims 1 to 8 for use in a process of preventing surgical adhesions which comprises positioning as a physical barrier, between the site of the surgical activity and neighboring tissue, the heparin-containing adhesion preventative barrier fabric of any of claims 1 to 8.
Claim 12
Dependent Claim
66 words
An oxidized regenerated cellulose fabric containing heparin absorbed on it said fabric being drapable, conformable, adherent to body organs, and substantially absorbable within thirty (30) days in the body, for use in a process of administering heparin topically to an internal body organ during surgery for the purpose of preventing surgical adhesions which comprises: applying the fabric to the outer surface of an internal body organ.
Claim 13
Dependent Claim
66 words
An oxidized regenerated cellulose fabric containing heparin absorbed on it said fabric being drapable, conformable, adherent to body organs, and substantially absorbable within thirty (30) days in the body, for use in a process of administering heparin topically to an internal body organ during surgery for the purpose of preventing surgical adhesions which comprises: applying the fabric to the outer surface of an internal body organ.
Claim 14
Dependent Claim
26 words
The product of claim 10 wherein the heparin is absorbed on the oxidized regenerated cellulose fabric after the fabric has been applied to said body organ.
Claim 15
Dependent Claim
25 words
The product of claim 11 wherein the heparin is absorbed on the oxidized regenerated cellulose fabric before the fabric is applied to the body organ.
Claim 16
Dependent Claim
94 words
The product of any one of claims 10 to 12 wherein the amount of heparin on the oxidized regenerated cellulose fabric is such that all the heparin remains on or in the fabric so no excess amount of heparin is present which could be spilled into or onto other organs or body cavities and is sufficient to contribute to improving the prevention of adhesions beyond that which would occur without the heparin but is not more than the amount which saturates the fabric and the potency of the heparin is 100-2000 USP Heparin Units.
References Cited (Backward Citations)
No citation records indexed.
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