EP0257955A2
Expired / Lapsed
EP
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Chemical sensor
Assignee: GE Healthcare Ltd
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Filing: 1987-08-18
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Granted: —
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Expires: 2007-08-18
Abstract
Abstract A chemically-sensitive surface plasmon resonance device comprises a slab (11) of a light-transmissive material (e.g. perspex) having a layer (14) of a metal on one side and a plurality of ridges (13) on the opposite side. A layer (15) of a chemically sensitive material is formed on the metal layer. White light incident on the ridges undergoes reflection at the interface of the slab (11) and metal layer (14) and is dispersed as it leaves the slab. Exposure of the chemically sensitive layer (15) to an analyte causes a change, as a function of wavelength of reflected light, of a plasmon resonance absorption.
Inventors
- 👤 Brian Christopher Webb
- 👤 Phelim Brinley Daniels
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-29 00:11
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/75; G01N21/77; G01N21/7703; G01N21/774; G01N21/7743; G01N21/17; G01N21/55; G01N21/552; G01N21/553
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
130 words
A chemically-sensitive surface plasmon resonance device comprising a slab of a light-transmissive material being flat on one side and having a plurality of formations on the opposite side, a layer of a metal formed on said one side of the slab and a layer of a chemically-sensitive material formed on, or in the vicinity of, said metal layer, whereby, in use, white light incident on said formations undergoes reflection at the interface of said one side and said metal layer and, after reflection, undergoes dispersion as the light leaves said opposite side and in a resonance condition of the device, exposure of said chemically-sensitive material to an analyte causes a detectable change, as a function of the wavelength of the reflected light, of the position of a plasmon resonance absorption.
Claim 2
Dependent Claim
130 words
A chemically-sensitive surface plasmon resonance device comprising a slab of a light-transmissive material being flat on one side and having a plurality of formations on the opposite side, a layer of a metal formed on said one side of the slab and a layer of a chemically-sensitive material formed on, or in the vicinity of, said metal layer, whereby, in use, white light incident on said formations undergoes reflection at the interface of said one side and said metal layer and, after reflection, undergoes dispersion as the light leaves said opposite side and in a resonance condition of the device, exposure of said chemically-sensitive material to an analyte causes a detectable change, as a function of the wavelength of the reflected light, of the position of a plasmon resonance absorption.
Claim 3
Dependent Claim
25 words
A chemically-sensitive surface plasmon resonance device according to Claim 1 wherein said formations comprise parallel ridges defined by respective pairs of flat, mutually inclined surfaces
Claim 4
Dependent Claim
24 words
A chemically-sensitive surface plasmon resonance device according to Claim 1 or Claim 2 wherein said slab is made of a mouldable optical quality material.
Claim 5
Dependent Claim
45 words
A chemically sensitive surface plasmon resonance device according to any one of Claims 1 to 3 including a cell for containing said analyte, said layer of a chemically-sensitive material being formed on a wall of the cell thereby to be in contact with the analyte.
Claim 6
Dependent Claim
29 words
A chemically-sensitive surface plasmon resonance device according to Claim 4 wherein said metal layer and said layer of a chemically-sensitive material are formed on different walls of the cell.
Claim 7
Dependent Claim
18 words
A chemically-sensitive surface plasmon resonance device according to Claim 5 wherein said chemically-sensitive material is an enzyme substrate.
Claim 8
Dependent Claim
22 words
A chemically-sensitive surface plasmon resonance device according to any one of Claims 4 to 6 wherein said cell is a flow-through cell.
Claim 9
Dependent Claim
69 words
A chemically-sensitive surface plasmon resonance system comprising a chemically-sensitive surface plasmon resonance device according to any one of Claims 1 to 7, a source for producing a collimated beam of white light incident on said opposite side, means to focus, at an image plane, a dispersed beam exitant from said opposite side and detection means having a response characteristic which can be scanned electrically relative to said image plane.
Claim 10
Dependent Claim
34 words
A chemically-sensitive surface plasmon resonance system according to Claim 8 wherein a part only of said layer of a metal is treated with said chemically-sensitive material enabling a reference dispersed beam to be formed.
Claim 11
Independent Claim
72 words
A method of manufacturing a chemically-sensitive surface plasmon device according to any one of Claims 1 to 7 including the steps of producing a sheet comprising a plurality of said slabs, forming a layer of a metal on said sheet, thereby to cover, at least partially, said one side of each slab sectioning the sheet to separate individual devices and providing said layer of a chemically-sensitive material either before or after sectioning.
Claim 12
Dependent Claim
59 words
An optical component suitable for use in a chemically-sensitove surface plasmon resonance device according to any one of Claims 1 to 7 the optical component comprising a slab of light-transmissive material which is flat on one side and is formed on the opposite side with a plurality of parallel ridges defined by respective pairs of flat, mutually inclined surfaces.
References Cited (Backward Citations)
No citation records indexed.
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