EP0253651A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Method for storing and processing blood
Assignee: Autologous Blood Corp
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Filing: 1987-07-15
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Granted: —
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Expires: 2007-07-15
Abstract
Abstract An apparatus for use in a blood processing and preservation system comprises a primary collection bag (41), blood collection means (43, 44) connected to the bag (41) and adapted to draw a unit of blood from a person and feed the blood into the bag (41), and a harness (42) connected to the bag (41) for conducting solutions and blood components into and out of the bag (41). The harness (42) includes first tube means (48, 52, 54) for removing at least one blood component from the bag (41) while retaining another component, second tube means (58, 56, 48 and 48, 51, 53) for moving a cryoprotective solution into and out of the bag (41), third tube means (59, 56, 48) for conducting a wash solution into and out of the bag (41), and identification means (64, 65) on the bag (41). The foregoing apparatus is usable in a blood system including the method steps of collecting a unit of blood from a person and delivering the blood to the collection bag (41), processing the blood to separate the components and removing the components except for the red blood cells from the bag (41), preparing the red blood cells for freezing by conducting a cryoprotective solution into the bag (41) and mixing this solution with the red blood cells, preserving the red blood cells by freezing, subsequently washing the red blood cells by conducting a wash solution and the cells into and out of the bag (41), and delivering the cells in the same collection bag (41) to a recipient. This method is especially suited for use in an autologous blood system where the blood is reinfused in the person who furnished the blood.
Inventors
- 👤 Cesare Robert Valeri
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 21:00
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/02; A61M1/0209
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
209 words
A blood system utilizing a sterile closed assembly including a primary bag and a tube harness, said tube harness having first and second sealed ports and a sterilely closed tube, comprising the steps of: a) collecting blood from a donor in said primary bag; b) separating said blood in said primary bag into a plurality of blood components; c) retaining in said primary bag a unit of one of said components while removing through said sterilely closed tube the remainder of said components; d) sterilely connecting to said first port a supply of cryoprotective solution; e) feeding said solution into said primary bag through said harness and mixing said solution with said unit; f) freezing the mixture of said unit and said solution in said primary bag; g) subsequently thawing said mixture in said primary bag; h) sterilely connecting said second port to a blood processor and a supply of wash solution; i) combining said wash solution with said mixture in said primary bag and said processor; j) separating said wash solution and said mixture from said unit and retaining said unit in said primary bag; and k) removing said primary bag from said blood processor, whereby said unit of blood component is available for infusion in a recipient.
Claim 2
Dependent Claim
209 words
A blood system utilizing a sterile closed assembly including a primary bag and a tube harness, said tube harness having first and second sealed ports and a sterilely closed tube, comprising the steps of: a) collecting blood from a donor in said primary bag; b) separating said blood in said primary bag into a plurality of blood components; c) retaining in said primary bag a unit of one of said components while removing through said sterilely closed tube the remainder of said components; d) sterilely connecting to said first port a supply of cryoprotective solution; e) feeding said solution into said primary bag through said harness and mixing said solution with said unit; f) freezing the mixture of said unit and said solution in said primary bag; g) subsequently thawing said mixture in said primary bag; h) sterilely connecting said second port to a blood processor and a supply of wash solution; i) combining said wash solution with said mixture in said primary bag and said processor; j) separating said wash solution and said mixture from said unit and retaining said unit in said primary bag; and k) removing said primary bag from said blood processor, whereby said unit of blood component is available for infusion in a recipient.
Claim 3
Dependent Claim
26 words
A system according to Claim 1, and further including the step of preparing an identification of said donor, and connecting said identification to said primary bag.
Claim 4
Dependent Claim
16 words
A system according to Claim 2, wherein said blood component is made available to said donor.
Claim 5
Dependent Claim
21 words
A system according to Claim 1, wherein said unit of one of said components comprises a unit of red blood cells.
Claim 6
Dependent Claim
46 words
A system according to Claim 1, wherein said tube harness further includes at least one secondary bag and said sterilely closed tube is connected to said secondary bag, and further comprising the step of flowing said remainder of said blood components into said one secondary bag.
Claim 7
Dependent Claim
15 words
A system according to Claim 5, wherein blood plasma is flowed into said secondary bag.
Claim 8
Dependent Claim
38 words
A system according to Claim 1, wherein said tube harness further includes at least one secondary bag connected to said sterilely closed tube, and further comprising the step of flowing any supernatant cryoprotective solution into said secondary bag.
Claim 9
Dependent Claim
64 words
A blood system according to Claim 1, wherein said wash solution and said mixture are combined by flowing a first portion of said wash solution into said primary bag and mixing with said unit, flowing the contents of said primary bag into said processor and separating said unit from said wash solution and said cryoprotective solution, and returning said unit to said primary bag.
Claim 10
Dependent Claim
37 words
A blood system according to Claim 8, wherein said one of said components comprises red blood cells, and further comprising the step of preparing an identification of said donor, and connecting said identification to said primary bag.
Claim 11
Dependent Claim
20 words
A blood system according to Claim 9, wherein said primary bag and the contents thereof are frozen at approximately -80°C.
Claim 12
Dependent Claim
86 words
A sterile closed assembly for use in a blood system, comprising: a) a primary bag; b) at least one secondary bag; c) first and second sterilely closed ports; d) tube means connecting said primary bag with said secondary bag and said ports; e) blood collection means connected to said primary bag and adapted to be connected to a person for drawing blood from the person and flowing the blood into said primary bag; and f) identification means connected to said primary bag for identifying the person.
Claim 13
Dependent Claim
86 words
A sterile closed assembly for use in a blood system, comprising: a) a primary bag; b) at least one secondary bag; c) first and second sterilely closed ports; d) tube means connecting said primary bag with said secondary bag and said ports; e) blood collection means connected to said primary bag and adapted to be connected to a person for drawing blood from the person and flowing the blood into said primary bag; and f) identification means connected to said primary bag for identifying the person.
Claim 14
Dependent Claim
46 words
Apparatus according to Claim 11, and further comprising a supply of a wash solution sterilely connected to one of said ports, and means for mixing said wash solution and the contents of said primary bag and for flowing a washed blood component into said primary bag.
Claim 15
Dependent Claim
78 words
A sterile closed assembly for use in a blood system, comprising: a) a primary bag; b) a first secondary bag; c) a second secondary bag; d) first and second sterilely closed ports; e) tube means connecting said primary bag with said secondary bags and said ports; and f) blood collection means connected to said primary bag and adapted to be connected to a person for drawing blood from the person and flowing the blood into said primary bag.
Claim 16
Dependent Claim
78 words
A sterile closed assembly for use in a blood system, comprising: a) a primary bag; b) a first secondary bag; c) a second secondary bag; d) first and second sterilely closed ports; e) tube means connecting said primary bag with said secondary bags and said ports; and f) blood collection means connected to said primary bag and adapted to be connected to a person for drawing blood from the person and flowing the blood into said primary bag.
Claim 17
Dependent Claim
37 words
Apparatus according to Claim 13, wherein said first secondary bag is for receipt from said primary bag of a blood component, and said second secondary bag is for receipt from said primary bag of a glycerol solution.
Claim 18
Dependent Claim
33 words
Apparatus according to Claim 14, wherein said first port is for sterile connection with a supply of glycerol solution, and said second port is for sterile connection with a supply of wash solution.
Claim 19
Dependent Claim
24 words
Apparatus according to Claim 13, and further comprising at least one provial adapted to receive a component of the blood drawn from the person.
Claim 20
Dependent Claim
151 words
Apparatus for use in a blood system, comprising: a) a primary bag; b) at least one secondary bag; c) first and second ports; d) tube means connecting said primary bag with said secondary bag and with said ports; e) blood collection means connected to said primary bag and adapted to be connected to a person for drawing blood from the person and flowing the blood into said primary bag; f) means for separating blood in said primary bag into components and retaining a unit of one component in said bag and flowing the remaining components into said secondary bag; g) a supply of cryoprotective solution adapted to be coannected to said first port for mixing with said unit in said primary bag; and h) a supply of wash solution adapted to be connected to said second port for mixing with said unit and with said cryoprotective solution in said primary bag.
Claim 21
Dependent Claim
151 words
Apparatus for use in a blood system, comprising: a) a primary bag; b) at least one secondary bag; c) first and second ports; d) tube means connecting said primary bag with said secondary bag and with said ports; e) blood collection means connected to said primary bag and adapted to be connected to a person for drawing blood from the person and flowing the blood into said primary bag; f) means for separating blood in said primary bag into components and retaining a unit of one component in said bag and flowing the remaining components into said secondary bag; g) a supply of cryoprotective solution adapted to be coannected to said first port for mixing with said unit in said primary bag; and h) a supply of wash solution adapted to be connected to said second port for mixing with said unit and with said cryoprotective solution in said primary bag.
Claim 22
Dependent Claim
19 words
Apparatus according to Claim 17, and further including identification means connected to said primary bag for identifying said person.
Claim 23
Dependent Claim
46 words
Apparatus according to Claim 17, and further including means for freezing said primary bag and the components thereof, and blood processing means for mixing said wash solution with said unit and separating said unit in said primary bag from said wash solution and said cryoprotective solution.
Claim 24
Independent Claim
103 words
A method of processing a blood component which has been frozen in a collection bag, the bag containing a mixture of the blood component and a cryoprotective agent, and the collection bag having a sterile tube connected thereto, said method comprising the steps of thawing said blood component in said bag, flowing a quantity of wash solution into said bag and forming in said bag a mixture of cryoprotective agent, wash solution and blood component, flowing said mixture into a separator and separating said blood component from the cryoprotective agent and the wash solution, and returning the blood component to the collection bag.
Claim 25
Independent Claim
103 words
A method of processing a blood component which has been frozen in a collection bag, the bag containing a mixture of the blood component and a cryoprotective agent, and the collection bag having a sterile tube connected thereto, said method comprising the steps of thawing said blood component in said bag, flowing a quantity of wash solution into said bag and forming in said bag a mixture of cryoprotective agent, wash solution and blood component, flowing said mixture into a separator and separating said blood component from the cryoprotective agent and the wash solution, and returning the blood component to the collection bag.
References Cited (Backward Citations)
No citation records indexed.
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