EP0253104A1
Expired / Lapsed
EP
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Controlled release bases for pharmaceuticals
Assignee: Mundipharma CVA
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Filing: 1987-05-22
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Granted: —
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Expires: 2007-05-22
Abstract
Abstract The release of therapeutically active agents from controlled release bases is extended by using a combination of a higher aliphatic alcohol and an acrylic resin as the base material.
Inventors
- 👤 Benjamin Oshlack
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 21:14
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2013; A61K47/00; A61K9/2022; A61K9/2027; A61P; A61P11/00; A61P11/08; A61P11/14; A61P25/00; A61P25/04; A61P25/18; A61P25/24; A61P25/26; A61P43/00; A61P9/00; A61P9/06
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
62 words
Extended action controlled release pharmaceutical composition for oral administration, comprising a pharmaceutically active agent distributed in a controlled release core or matrix comprising a higher aliphatic alcohol of 10-18 carbon atoms and a pharmaceutically acceptable acrylic resin, said acrylic resin being in an amount of about 10-60% by weight of the weight of said higher aliphatic alcohol plus the said acrylic resin.
Claim 2
Dependent Claim
62 words
Extended action controlled release pharmaceutical composition for oral administration, comprising a pharmaceutically active agent distributed in a controlled release core or matrix comprising a higher aliphatic alcohol of 10-18 carbon atoms and a pharmaceutically acceptable acrylic resin, said acrylic resin being in an amount of about 10-60% by weight of the weight of said higher aliphatic alcohol plus the said acrylic resin.
Claim 3
Dependent Claim
18 words
Pharmaceutical composition according to claim 1 wherein said acrylic resin is an amount of about 15-40% by weight.
Claim 4
Dependent Claim
19 words
Pharmaceutical composition according to claim 1 wherein said acrylic resin is in an amount of about 20-35% by weight.
Claim 5
Dependent Claim
15 words
Pharmaceutical composition according to claim 1 wherein said core or matrix also includes a binder.
Claim 6
Dependent Claim
15 words
Pharmaceutical composition according to claim 4 wherein said core or matrix also includes a filler.
Claim 7
Dependent Claim
15 words
Pharmaceutical composition according to claim 5 wherein said core or matrix also includes a disintegrant.
Claim 8
Dependent Claim
15 words
Pharmaceutical composition according to claim 6 wherein said core or matrix also includes a lubricant.
Claim 9
Dependent Claim
19 words
Pharmaceutical composition according to claim 1 wherein said core or matrix constitutes about 20-40% by weight of said composition.
Claim 10
Dependent Claim
15 words
Pharmaceutical composition according to claim 1 wherein said pharmaceutically active agent is highly water soluble.
Claim 11
Dependent Claim
31 words
Pharmaceutical composition according to claim 1 wherein said pharmaceutical agent is amitryptaline, atropine, chlorpheniramine, chlorpromizine, codeine, dexbrompheniramine, diphenylhydramine, doxilamine, ephedrine, hyoscyamine, morphine, oxycodone, papavarine, phenylpropanolamine, propranolol, quinidine, scoplamine, theophylline or thioridazine.
Claim 12
Dependent Claim
65 words
Core or matrix for controlled release pharmaceutical compositions for oral administration and being adapted for distribution therein of a pharmaceutically active agent, said core or matrix comprising a higher aliphatic alcohol of 10-18 carbon atoms and a pharmaceutically acceptable acrylic resin, said acrylic resin being in an amount of about 10-60% by weight of the weight of said higher aliphatic alcohol and said acrylic resin.
Claim 13
Dependent Claim
65 words
Core or matrix for controlled release pharmaceutical compositions for oral administration and being adapted for distribution therein of a pharmaceutically active agent, said core or matrix comprising a higher aliphatic alcohol of 10-18 carbon atoms and a pharmaceutically acceptable acrylic resin, said acrylic resin being in an amount of about 10-60% by weight of the weight of said higher aliphatic alcohol and said acrylic resin.
Claim 14
Dependent Claim
19 words
Core or matrix according to claim 11 wherein the amount of said acrylic resin is about 15-40% by weight.
Claim 15
Dependent Claim
19 words
Core or matrix according to claim 11 wherein the amount of said acrylic resin is about 20-35% by weight.
Claim 16
Dependent Claim
14 words
Pharmaceutical composition according to claim 1 and being in the form of a tablet.
Claim 17
Dependent Claim
14 words
Pharmaceutical composition according to claim 1 and being in the form of a caplet.
Claim 18
Dependent Claim
11 words
Pharmaceutical composition according to claim 1 and being in capsule form
References Cited (Backward Citations)
EP0068450A2
Cited
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