EP0251695A2
Expired / Lapsed
EP
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Injectable implant composition having improved intrudability
Assignee: Collagen Aesthetics Inc
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Filing: 1987-06-24
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Granted: —
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Expires: 2007-06-24
Abstract
Abstract Injectable aqueous suspensions of biomaterials, such as cross-linked collagen, that contain a biocompatible fluid lubricant, such as glycogen or maltose, are disclosed. The inclusion of the lubricant significantly improves the intrusion of the suspension into soft tissue.
Inventors
- 👤 Donald G. Wallace
- 👤 Hertsel Reihanian
- 👤 Bruce B. Pharriss
- 👤 William G. Braun
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 16:53
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/39; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/26; A61L27/50; A61F; A61F2/00; A61F2/0059; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2400/00; A61L2400/06
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
37 words
An injectable implant composition for soft tissue augmentation comprising an aqueous suspension of a particulate biomaterial and a sufficient amount of a biocompatible fluid lubricant to significantly improve the intrudability of the composition into the soft tissue.
Claim 2
Dependent Claim
37 words
An injectable implant composition for soft tissue augmentation comprising an aqueous suspension of a particulate biomaterial and a sufficient amount of a biocompatible fluid lubricant to significantly improve the intrudability of the composition into the soft tissue.
Claim 3
Dependent Claim
21 words
The composition of claim 1 wherein the particulate biomaterial is fibrillar cross-linked collagen, or beads of a synthetic or natural polymer.
Claim 4
Dependent Claim
48 words
The composition of claim 1 wherein the particles of biomaterial are (a) rigid, generally spherical in shape and have diameters in the range of about 1 to 20 microns or (b) deformable, asymmetric in shape, and are 500-800 microns in length and less than 30 microns in width.
Claim 5
Dependent Claim
26 words
The composition of claim 1, 2 or 3 wherein the concentration of particulate biomaterial in the suspension is in the range of 1% to 20% W/V.
Claim 6
Dependent Claim
24 words
The composition of claim 1, 2, 3, or 4 wherein the concentration of said lubricant in the suspension is about 0.01% to 40% W/V.
Claim 7
Dependent Claim
92 words
The composition of claim 1, 2, 3, 4 or 5 wherein the lubricant is (a) a charged polymer selected from the group consisting of methylated collagen, succinylated collagen, or dextran sulfate, (b) an uncharged polymer selection from the group consisting of dextran, heparin, and glycogen, and the concentration of lubricant in the suspension is 10% to 40% W/V. (c) a neutral lubricant selected from the group consisting of maltose, dextrose, a triglyceride of a fatty acid, egg yolk phospholipid, or glycerol, and is present in the suspension at 10% to 40% W/V.
Claim 8
Dependent Claim
16 words
The composition of claim 1, 2, 3, 4 or 5 wherein the lubricant is hyaluronic acid.
Claim 9
Dependent Claim
31 words
The composition of claim 1, 2, 3, 4, 5, 6 or 7 wherein the biomaterial is cross-linked collagen and the concentration of biomaterial in the suspension is 3% to 6% W/V.
Claim 10
Independent Claim
40 words
A method of improving the injectability of an aqueous suspension of a particulate biomaterial into soft tissue comprising incorporating a sufficient amount of a biocompatible fluid lubricant in the suspension to enhance the intrudability of the suspension into the tissue.
Claim 11
Independent Claim
40 words
A method of improving the injectability of an aqueous suspension of a particulate biomaterial into soft tissue comprising incorporating a sufficient amount of a biocompatible fluid lubricant in the suspension to enhance the intrudability of the suspension into the tissue.
References Cited (Backward Citations)
No citation records indexed.
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