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EP0250125A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Drug delivery device, its preparation and use

Assignee: Smith and Nephew PLC
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Filing: 1987-06-03
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Granted: —
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Expires: 2007-06-03
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Abstract

Abstract A device suitable for the topical administration of a pharmacologically active agent to an animal is described. The device comprises an active agent impermeable barrier layer, a reservoir containing the active agent which is in contact with the inner surface of the barrier layer and a removable protector layer in contact with the other surface of the reservoir. The reservoir comprises a fibrous mat into which the pharmacologically active agent is incorporated either by dissolving in the polymer forming the mat or by impregnation of a preformed mat. Alternative forms of the reservoir comprise a fibre mat coated on a skin contacting surface with a pressure sensitive adhesive and a fibre mat contained within a gel matrix. The device may be used to deliver nitroglycerin, oxybutynin or phenazocine transdermally.

Inventors

  • 👤 Peter William Berry
  • 👤 Paul Holden

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-26 23:00
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084

Claims Analysis

Total Claims: 14
Claim 1
Independent Claim 57 words
A device suitable for the topical administration of a pharmacologically active agent comprising an active agent impermeable barrier layer, a reservoir comprising a fibre mat containing the pharmacologically active agent having one surface in contact with the inner surface of the barrier layer and a protector layer removably in contact with the other surface of the reservoir.
Claim 2
Independent Claim 57 words
A device suitable for the topical administration of a pharmacologically active agent comprising an active agent impermeable barrier layer, a reservoir comprising a fibre mat containing the pharmacologically active agent having one surface in contact with the inner surface of the barrier layer and a protector layer removably in contact with the other surface of the reservoir.
Claim 3
Dependent Claim 20 words
A device as claimed in claim 1 in which the fibre mat is formed from fibres of a thermoplastic polyurethane.
Claim 4
Dependent Claim 32 words
A device as claimed in claim 1 in which the fibre mat is formed from fibres of a hydrophilic polyurethane which contains from 10 to 50% by weight of water when hydrated.
Claim 5
Dependent Claim 24 words
A device as claimed in claim 1 in which the weight per unit area of the fibre mat is from 150 to 250 gsm.
Claim 6
Independent Claim 34 words
A device as claimed in any one of claims 1 to 4 in which the reservoir comprises a fibre mat coated on its body contacting surface with a layer of a pressure sensitive adhesive.
Claim 7
Dependent Claim 23 words
A device as claimed in claim 5 in which the adhesive is present at a weight per unit area of below 25 gsm.
Claim 8
Independent Claim 20 words
A device as claimed in either of claims 5 or 6 in which the adhesive is polyvinyl ethyl ether adhesive.
Claim 9
Dependent Claim 28 words
A device as claimed in claim 1 in which the reservoir comprises a fibre mat supported in a polymer matrix which is permeable to the pharmacologically active agent.
Claim 10
Dependent Claim 16 words
A device as claimed in claim 8 in which the polymer matrix is a silicone gel.
Claim 11
Independent Claim 38 words
A device as claimed in any one of claims 1 to 9 in which the impermeable barrier layer has an area which extends beyond the reservoir around its periphery and is adhesive coated for adhesion to the skin.
Claim 12
Independent Claim 35 words
A device as claimed in any one of claims 1 to 9 in which there is additionally present an adhesive coated cover layer which covers and extends beyond the periphery of the impermeable barrier layer.
Claim 13
Independent Claim 29 words
A device as claimed in any one of claims 1 to 11 in which the barrier layer comprises a backing film coated on its inner surface with an adhesive.
Claim 14
Independent Claim 38 words
A device as claimed in any of claims 1 to 11 in which the pharmacologically active agent is selected from the group consisting of nitroglycerin, cloridine, scopolamine, isosorbide dinitrate, pentaerythritol tetranitrate, estradiol, indomethacine, verapamil, propranolol, oxybutynin and phenazocine.

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