EP0248531A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Encapsulated nucleic acids
Assignee: Southern Research Institute
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Filing: 1987-05-01
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Granted: —
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Expires: 2007-05-01
Abstract
Abstract RNA and/or DNA, e.g. poly(I:C) or anti-sense RNA, is encapsulated as microcapsules in a biodegradable, biocompatible polymeric material, for the controlled release of the nucleic acid on administration and the induction of interferon production.
Inventors
- 👤 Thomas R. Tice
- 👤 Kenneth L. Pledger
- 👤 Richard M. Gilley
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 23:42
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
16 words
A composition which comprises RNA and/or DNA encapsulated as microcapsules in a biodegradable, biocompatible polymeric material.
Claim 2
Dependent Claim
16 words
A composition which comprises RNA and/or DNA encapsulated as microcapsules in a biodegradable, biocompatible polymeric material.
Claim 3
Dependent Claim
13 words
A composition according to claim 1, wherein the RNA and/or DNA is RNA.
Claim 4
Dependent Claim
17 words
A composition according to claim 1, wherein the RNA and/or DNA is a complex of polyriboinosinic-polyribocytidylic acid.
Claim 5
Dependent Claim
26 words
4 A composition according to any preceding claim, which comprises from 0.01 to 75 wt. % of the RNA and/or DNA based on the polymeric material.
Claim 6
Dependent Claim
17 words
A composition according to any of claims 1 to 4, wherein the RNA and/or DNA is double-stranded.
Claim 7
Dependent Claim
17 words
A composition according to any of claims 1 to 4, wherein the RNA and/or DNA is single-stranded.
Claim 8
Dependent Claim
30 words
A composition according to any preceding claim, wherein the polymer is selected from poly(D,L-lactide), poly(glycolic acid), copolymers of mixed D,L-lactide and glycolide, copolyoxalates, polycaprolactone, poly(lactide-co-caprolactone), poly(esteramides) and poly(betahydroxy butyric acid).
Claim 9
Dependent Claim
11 words
A composition according to claim 3, wherein the polymer is poly(DL-lactide-co-glycolide).
Claim 10
Dependent Claim
26 words
A composition according to any preceding claim, which comprises a pharmaceutically acceptable carrier for the microcapsules, the carrier being suitable for parenteral administration to an animal.
Claim 11
Dependent Claim
51 words
The use of a composition according to any preceding claim for the manufacture of a medicament for use in protecting an animal from viral infections, the RNA and/or DNA being released at a controlled, predetermined rate to induce the production of interferon and thereby stimulate the immune system of the animal.
References Cited (Backward Citations)
No citation records indexed.
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