EP0242173A1
Expired / Lapsed
EP
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Antiarrhythmic agents
Assignee: Pfizer Ltd
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Filing: 1987-04-14
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Granted: —
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Expires: 2007-04-14
Abstract
Abstract Antiarrhythmic agents of the formula:- and their pharmaceutically acceptable salts, wherein R is a C₁-C₄ alkyl group; R¹ is a C₁-C₄ alkyl group; X is -CH₂-, -CO- or -CH(OH)-; n is 2, 3 or 4; and "Het" is a 5- or 6-membered nitrogen-containing heterocyclic group which is attached to the adjacent carbon atom by a carbon or nitrogen atom and optionally contains a further heteroatom selected from 0 and N, said 5- or 6-membered nitrogen-containing heterocyclic group being either (i) substituted by a phenyl or benzyl group or (ii) fused at two adjacent carbon atoms to a benzene ring, said benzene ring being optionally substituted by 1 or 2 substituents each independently selected from halo and C₁-C₄ alkyl, and said 5- or 6-membered nitrogen-containing heterocyclic group being optionally substituted by up to 2 substituents each independently selected from oxo, halo and C₁-C₄ alkyl with the proviso that only one oxo substituent can be present.
Inventors
- 👤 Peter Edward Cross
- 👤 John Edmund Arrowsmith
- 👤 Geoffrey Noel Thomas
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-27 09:14
CPC Classifications
C; C07; C07D; C07D237/00; C07D237/26; C07D215/00; C07D215/02; C07D215/16; C07D215/20; C07D215/22; C07D215/227; A; A61; A61P; A61P9/00; A61P9/06; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/14; C07D209/44; C07D209/46; C07D215/12; C07D217/00; C07D217/22; C07D217/24; C07D237/02; C07D237/06; C07D237/10; C07D237/14; C07D237/30; C07D237/32; C07D239/00; C07D239/70; C07D239/72; C07D239/86; C07D239/88; C07D239/90; C07D263/00; C07D263/52; C07D263/54; C07D263/58
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
155 words
A compound of the formula:- or a pharmaceutically acceptable salt thereof, wherein R is a C₁-C₄ alkyl group; R¹ is a C₁-C₄ alkyl group; X is -CH₂-, -CO- or -CH(OH)-; n is 2, 3 or 4; and "Het" is a 5- or 6-membered nitrogen-containing heterocyclic group which is attached to the adjacent carbon atom by a carbon or nitrogen atom and optionally contains a further heteroatom selected from 0 and N, said 5- or 6-membered nitrogen-containing heterocyclic group being either (i) substituted by a phenyl or benzyl group or (ii) fused at two adjacent carbon atoms to a benzene ring, said benzene ring being optionally substituted by 1 or 2 substituents each independently selected from halo and C₁-C₄ alkyl, and said 5- or 6-membered nitrogen-containing heterocyclic group being optionally substituted by up to 2 substituents each independently selected from oxo, halo and C₁-C₄ alkyl with the proviso that only one oxo substituent can be present.
Claim 2
Dependent Claim
155 words
A compound of the formula:- or a pharmaceutically acceptable salt thereof, wherein R is a C₁-C₄ alkyl group; R¹ is a C₁-C₄ alkyl group; X is -CH₂-, -CO- or -CH(OH)-; n is 2, 3 or 4; and "Het" is a 5- or 6-membered nitrogen-containing heterocyclic group which is attached to the adjacent carbon atom by a carbon or nitrogen atom and optionally contains a further heteroatom selected from 0 and N, said 5- or 6-membered nitrogen-containing heterocyclic group being either (i) substituted by a phenyl or benzyl group or (ii) fused at two adjacent carbon atoms to a benzene ring, said benzene ring being optionally substituted by 1 or 2 substituents each independently selected from halo and C₁-C₄ alkyl, and said 5- or 6-membered nitrogen-containing heterocyclic group being optionally substituted by up to 2 substituents each independently selected from oxo, halo and C₁-C₄ alkyl with the proviso that only one oxo substituent can be present.
Claim 3
Dependent Claim
55 words
A compound as claimed in claim 1 wherein "Het" is a group of the formula:- wherein R² is phenyl or benzyl; R³ is H, halo or C₁-C₄ alkyl; R⁴, which is attached to a carbon atom of the benzene ring portion, is H, halo or C₁-C₄ alkyl; and the dotted line represents an optional bond.
Claim 4
Dependent Claim
12 words
A compound as claimed in claim 2 wherein "Het" is selected from:-
Claim 5
Dependent Claim
26 words
A compound as claimed in any one of the preceding claims, wherein R is CH₃, R¹ is CH₃ or C₂H₅ and n is 2 or 3.
Claim 6
Dependent Claim
20 words
A compound as claimed in claim 4 wherein n is 2, R¹ is Ch₃ and X is -CH₂- or -CH(OH)-.
Claim 7
Dependent Claim
10 words
A compound as claimed in claim 1 of the formula:-
Claim 8
Dependent Claim
32 words
A pharmaceutical composition comprising a compound of the formula (I) as claimed in any one of the preceding claims, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable diluent or carrier.
Claim 9
Dependent Claim
27 words
A compound of the formula (I) as claimed in any one of claims 1 to 6, or a pharmaceutically acceptable salt thereof, for use as a medicament.
Claim 10
Dependent Claim
28 words
The use of a compound of the formula (I), or of a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for use as an antiarrhythmic agent.
Claim 11
Dependent Claim
28 words
The use of a compound of the formula (I), or of a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for use as an antiarrhythmic agent.
References Cited (Backward Citations)
FR2302733A1
Cited
FR2343731A1
Cited
FR2363564A1
Cited
CH645628A5
Cited
EP0008653A1
Cited
GB2135883A
Cited
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