EP0238335A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Apparatus for plasmapheresis
Assignee: Toray Industries Inc
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Filing: 1987-03-19
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Granted: —
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Expires: 2007-03-19
Abstract
Abstract An apparatus for fractionating a cell suspension, comprises a case body (2,l2) having a substantially columnar space in the interior, which is substantially closed to the outside, a liquid-treating chamber (3) filled with the cell suspension circulating through this liquid-treating chamber (3), a separating membrane (32) which is disposed to separate a predetermined component and allow this component to pass through the separating membrane (32), a rotary body (5l) rotatably arranged in the liquid-treating chamber (3), a driving mechanism for rotating and driving the rotary body (5l), a cell suspension introduction path (42), a treated liquid discharge path (7), and a separated component discharge path (l9).
Inventors
- 👤 Masato Haraguchi
- 👤 Yuichi Mori
- 👤 Ichiro Itagaki
- 👤 Masao Hirose
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-30 19:03
CPC Classifications
B; B01; B01D; B01D63/00; B01D63/16; A; A61; A61M; A61M1/00; A61M1/34; B01D29/00; B01D29/01; B01D29/018; B01D29/50; B01D29/52; B01D29/54; B01D29/76; B01D29/86; B01D33/00; B01D33/15; B01D33/21; B01D33/35; B01D33/37; B01D33/39; B01D33/58; B01D33/68; B01D63/08; B01D63/087; B01D65/00; B01D65/08; B01D2321/00; B01D2321/16; B01D2321/168; B01D2321/20; B01D2321/2008; B01D2321/2016; Y; Y10; Y10S; Y10S210/00; Y10S210/929
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
202 words
An apparatus for fractionating a cell suspension, which comprises (a) a case body having a substantially columnar space in the interior thereof, which is substantially closed to the outside, (b) a liquid-treating chamber disposed in the case body and filled with the cell suspension circulating therethrough, (c) a separated component chamber disposed in the case body, (d) a separating membrane having a separating wall surface having a certain area, which is interposed between the liquid-treating chamber and the separated component chamber to separate a predetermined component and allow said component to pass therethrough, (e) a disc-like rotary body having a shearing wall surface having a certain area confronting the separating wall surface at a certain distance, which is rotatably disposed in the liquid-treating chamber, (f) a driving mechanism engaged with the rotary body to rotate and drive the rotary body, (g) a liquid introduction path connected to the liquid-treating chamber and extended to the outside of the case body, (h) a treated liquid discharge path connected to the liquid-treating chamber and extended to the outside of the case body, and (i) a separated component liquid discharge path connected to the separated component chamber and extended to the outside of the case body.
Claim 2
Independent Claim
202 words
An apparatus for fractionating a cell suspension, which comprises (a) a case body having a substantially columnar space in the interior thereof, which is substantially closed to the outside, (b) a liquid-treating chamber disposed in the case body and filled with the cell suspension circulating therethrough, (c) a separated component chamber disposed in the case body, (d) a separating membrane having a separating wall surface having a certain area, which is interposed between the liquid-treating chamber and the separated component chamber to separate a predetermined component and allow said component to pass therethrough, (e) a disc-like rotary body having a shearing wall surface having a certain area confronting the separating wall surface at a certain distance, which is rotatably disposed in the liquid-treating chamber, (f) a driving mechanism engaged with the rotary body to rotate and drive the rotary body, (g) a liquid introduction path connected to the liquid-treating chamber and extended to the outside of the case body, (h) a treated liquid discharge path connected to the liquid-treating chamber and extended to the outside of the case body, and (i) a separated component liquid discharge path connected to the separated component chamber and extended to the outside of the case body.
Claim 3
Independent Claim
215 words
An apparatus for fractionating a cell suspension, which comprises (a) a case body having a substantially columnar space in the interior thereof, which is substantially closed to the outside, (b) a liquid-treating chamber disposed in the case body and filled with the cell suspension circulating therethrough, (c) a shearing wall surface having a certain area formed on a part of the inner wall surface of the liquid-treating chamber, (d) a separating membrane having a separating wall surface having a certain area which confronts the shearing wall surface at a certain distance, said membrane being disposed to separate a predetermined component and allow said component to pass therethrough, (e) a disc-like rotary body supporting the separating membrane and having a separated component chamber on the back surface of the separating membrane, which is rotatably arranged in the liquid-treating chamber, (f) a driving mechanism engaged with the rotary body to rotate and drive the rotary body, (g) a liquid introduction path connected to the liquid-treating chamber and extended to the outside of the case body, (h) a treated liquid discharge path connected to the liquid-treating chamber and extended to the outside of the case body, and (i) a separated component liquid path connected to the separated component chamber and extended to the outside of the case body.
Claim 4
Independent Claim
215 words
An apparatus for fractionating a cell suspension, which comprises (a) a case body having a substantially columnar space in the interior thereof, which is substantially closed to the outside, (b) a liquid-treating chamber disposed in the case body and filled with the cell suspension circulating therethrough, (c) a shearing wall surface having a certain area formed on a part of the inner wall surface of the liquid-treating chamber, (d) a separating membrane having a separating wall surface having a certain area which confronts the shearing wall surface at a certain distance, said membrane being disposed to separate a predetermined component and allow said component to pass therethrough, (e) a disc-like rotary body supporting the separating membrane and having a separated component chamber on the back surface of the separating membrane, which is rotatably arranged in the liquid-treating chamber, (f) a driving mechanism engaged with the rotary body to rotate and drive the rotary body, (g) a liquid introduction path connected to the liquid-treating chamber and extended to the outside of the case body, (h) a treated liquid discharge path connected to the liquid-treating chamber and extended to the outside of the case body, and (i) a separated component liquid path connected to the separated component chamber and extended to the outside of the case body.
Claim 5
Dependent Claim
27 words
A cell suspension-fractionating apparatus as set forth in claim l or 2, wherein the cell suspension is blood and the predetermined component to be separated is plasma.
Claim 6
Dependent Claim
28 words
A cell suspension-fractionating apparatus as set forth in claim l or 2, wherein the average diameter of the pores of the separating membrane is 0.2 to l.0 µm.
Claim 7
Dependent Claim
26 words
A cell suspension-fractionating apparatus as set forth in claim 4, wherein the average diameter of the pores of the separating membrane is 0.4 to 0.8 µm.
Claim 8
Dependent Claim
21 words
A cell suspension-fractionating apparatus as set forth in claim l or 2, wherein the separating membrane is composed of a polycarbonate.
Claim 9
Dependent Claim
23 words
A cell suspension-fractionating apparatus as set forth in claim l or 2, wherein the separating membrane is composed of a cellulose mixed ester.
Claim 10
Dependent Claim
20 words
A cell suspension-fractionating apparatus as set forth in claim l or 2, wherein the separating membrane is composed of polyethylene.
Claim 11
Dependent Claim
21 words
A cell suspension-fractionating apparatus as set forth in claim l or 2, wherein the separating membrane is composed of a polysulfone.
Claim 12
Dependent Claim
23 words
l0. A cell suspension-fractionating apparatus as set forth in claim l or 2, wherein the separating membrane is composed of a ceramic material.
Claim 13
Dependent Claim
25 words
A cell suspension-fractionating apparatus as set forth in claim l or 2, wherein the area of the separating wall surface is l0 to l00 cm².
Claim 14
Dependent Claim
28 words
A cell suspension-fractionating apparatus as set forth in claim l or 2, wherein each of the separating wall surface and the shearing wall surface is a plane surface.
Claim 15
Dependent Claim
28 words
A cell suspension-fractionating apparatus as set forth in claim l2, wherein the distance between the separating wall surface and the shearing wall surface in 0.05 to 2 mm.
Claim 16
Dependent Claim
24 words
A cell suspension-fractionating apparatus as set forth in claim l3, wherein the outer diameter of the shearing wall surface is 30 to l00 mm.
Claim 17
Dependent Claim
34 words
A cell suspension-fractionating apparatus as set forth in claim l or 2, wherein one of the separating wall surface and the shearing wall surface is a conical surface convex to the other wall surface.
Claim 18
Dependent Claim
28 words
A cell suspension-fractionating apparatus as set forth in claim l5, wherein the crossing angle between the separating wall surface and the shearing wall surface is 0.5° to 5°.
Claim 19
Dependent Claim
28 words
A cell suspension-fractionating apparatus as set forth in claim l6, wherein the crossing angle between the separating wall surface and the shearing wall surface is 0.8° to 3°.
Claim 20
Dependent Claim
24 words
A cell suspension-fractionating apparatus as set forth in claim l5, wherein the outer diameter of the shearing wall surface is 20 to l00 mm.
Claim 21
Dependent Claim
19 words
A cell suspension-fractionating apparatus as set forth in claim l5, wherein the separating wall surface is a plane surface.
Claim 22
Dependent Claim
34 words
A cell suspension-fractionating apparatus as set forth in claim l or 2, wherein each of the separating wall surface and the shearing wall surface is a conical surface convex to the other wall surface.
Claim 23
Dependent Claim
29 words
2l. A cell suspension-fractionating apparatus as set forth in claim 20, wherein the crossing angle between the separating wall surface and the shearing wall surface is 0.5° to 5°.
Claim 24
Dependent Claim
28 words
A cell suspension-fractionating apparatus as set forth in claim 2l, wherein the crossing angle between the separating wall surface and the shearing wall surface is 0.8° to 3°.
Claim 25
Dependent Claim
24 words
A cell suspension-fractionating apparatus as set forth in claim 20, wherein the outer diameter of the shearing wall surface is 20 to l00 mm.
Claim 26
Dependent Claim
24 words
A cell suspension-fractionating apparatus as set forth in claim l or 2, wherein one separating wall surface and one shearing wall surface are disposed.
Claim 27
Dependent Claim
24 words
A cell suspension-fractionating apparatus as set forth in claim l or 2, wherein two separating wall surfaces and two shearing wall surfaces are disposed.
Claim 28
Dependent Claim
27 words
A cell suspension-fractionating apparatus as set forth in claim 25, wherein one separating wall surface is arranged on each of both surfaces of one separated component chamber.
Claim 29
Dependent Claim
26 words
A cell suspension-fractionating apparatus as set forth in claim 25, wherein one separating wall surface is arranged on each of both surfaces of one liquid-treating chamber.
Claim 30
Dependent Claim
51 words
A cell suspension-fractionating apparatus as set forth in claim l or 2, wherein the driving mechanism for rotating and driving the rotary body comprises a driving shaft attached to the rotary body and extended to the outside of the case body and a motor for rotating and driving the driving shaft.
Claim 31
Dependent Claim
56 words
A cell suspension-fractionating apparatus as set forth in claim l or 2, wherein the driving mechanism for rotating and driving the rotary body comprises a magnetic coupling member mounted on the rotary body and means arranged outside the case body and magnetically connected to the magnetic coupling member to rotate and drive the magnetic coupling member.
References Cited (Backward Citations)
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