EP0235796A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Dibenz [b,e] oxepin derivative and antiallergic and antiinflammatory agent
Assignee: KH Neochem Co Ltd
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Filing: 1987-03-03
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Granted: —
•
Expires: 2007-03-03
Abstract
Abstract Novel dibenz[b,e]oxepin derivatives are employed in the treatment and control of allergic conditions such as allergic asthma and also employed in the treatment of inflammation.
Inventors
- 👤 Etsuo C/O Kyowa Hakko Kogyo Co. Ltd Oshima
- 👤 Toshiaki C/O Kyowa Hakko Kogyo Co. Ltd Kumazawa
- 👤 Shizuo C/O Kyowa Hakko Kogyo Co. Ltd Otaki
- 👤 Hiroyuki C/O Kyowa Hakko Kogyo Co. Ltd Obase
- 👤 Kenji C/O Kyowa Hakko Kogyo Co. Ltd Ohmori
- 👤 Hidee C/O Kyowa Hakko Koggyo Co. Ltd Ishii
- 👤 Haruhiko C/O Kyowa Hakko Kogyo Co. Ltd Manabe
- 👤 Tadafumi C/O Kyowa Hakko Kogyo Co. Ltd Tamura
- 👤 Katsuichi C/O Kyowa Hakko Kogyo Co. Ltd Shuto
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 21:38
CPC Classifications
C; C07; C07D; C07D405/00; C07D405/02; C07D405/06; A; A61; A61P; A61P29/00; A61P37/00; A61P37/08; C07D313/00; C07D313/02; C07D313/06; C07D313/10; C07D313/12; C07D405/12
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
194 words
I. A dibenz[b,e]oxepin compound represented by the formula (I) wherein A represents a hydroxymethyl, a lower alkoxymethyl, a triphenylmethyloxymethyl, a lower alkanoyloxymethyl, a lower alkanoyl, a carboxy, a lower alkoxy carbonyl, a triphenylmethyloxycarbonyl, 4,4-dimethyl-2-oxazoline-2-yl group, -CONHOH or -CONR 1 R 2 wherein R, and R2 are the same or different and represent hydrogen atom or lower alkyl; Y represents -(CH2) m -, -CHR 3 -(CH 2 ) m- or -CR4 =CR 5 -(CH2) m wherein R 3 represents a lower alkyl, R 4 and R s are the same or different and represent a hydrogen atom or a lower alkyl, and m is 0, I, 2, 3 or 4, which is the substituent at 2-or 3-position of the mother nucleus and the left side of the group Y is bound to benzen nucleus; X represents = N-, = CH-or -CH 2 -; n is 0, 1, 2, 3 or 4; Z represents 4-methylpiperazino, 4-methylhomopiperazino, piperidino, pyrrolidino, thiomorpholino, morpholino or -NR 6 R 7 wherein R 6 and R, are the same or different and represent hydrogen atom or a lower alkyl; and means single bond or double bond; and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
28 words
A compound according to claim I, wherein said salt is selected from acid addition salt, metal salt, ammonium salt, organic amine addition salt, and amino acid addition salt.
Claim 3
Dependent Claim
69 words
A compound according to claim I, wherein A is a member selected from the group consisting of hydroxymethyl, lower alkoxycarbonyl, -CONR,R2 and carboxyl; Y is bound at 2-position of the mother nucleus; X is a member selected from the group consisting of = N-and = CH-; n is I or 2; and Z is a member selected from the group consisting of dimethylamino, diethylamino, methylamino, amino, morpholino and thiomorpholino.
Claim 4
Dependent Claim
46 words
A compound according to claim 3, wherein Y is a member selected from the group consisting of - (CH 2 ) m -, CH (CH 2 ) m- and CH = CH-(CH 2 ) m -; and m is 0, 1 or 2. C H 3
Claim 5
Dependent Claim
25 words
A compound according to claim 4, wherein A is a member selected from the group consisting of hydroxymethyl and carboxyl; and X is = CH-.
Claim 6
Dependent Claim
48 words
A compound according to claim I, wherein -Y-A is a member selected from the group consisting of carboxyl, carboxymethyl, 2-carboxyethyl, 2-hydroxyethyl and 2-carboxyethenyl X is = CH-, n is 2 and Z is a member selected from the group consisting of dimethylamino, diethylamino, methylamino, amino, morpholino and thiomorpholino.
Claim 7
Dependent Claim
20 words
A compound according to claim I, wherein -Y-A is 2-COOH, X is =CH-, n is 2 and Z is dimethylamino.
Claim 8
Dependent Claim
20 words
A compound according to claim I, wherein -Y-A is 2-COOH, X is =CH-, n is 2 and Z is diethylamino.
Claim 9
Dependent Claim
21 words
A compound according to claim I, wherein -Y-A is 2-CH2COOH, X is = CH-, n is 2 and Z is dimethylamino.
Claim 10
Dependent Claim
24 words
A compound according to claim I, wherein -Y-A is 2-CH 2 CH 2 COOH, X is =CH-, n is 2 and Z is dimethylamino.
Claim 11
Dependent Claim
25 words
II. A compound according to claim I, wherein -Y-A is 2-CH 2 CH 2 OH, X is =CH-, n is 2 and Z is dimethylamino.
Claim 12
Dependent Claim
21 words
A compound according to claim 1, wherein -Y-A is 2-CH 2 COOH, X is =N-,n is 2 and Z is dimethylamino.
Claim 13
Dependent Claim
19 words
A compound according to claim 1, wherein -Y-A-is 2-COOH, X is =CH-, n is 2 and Z is morpholino.
Claim 14
Dependent Claim
20 words
A compound according to claim I, wherein -Y-A is 2-COOH, X is =CH-, n is 2 and Z is thiomorpholino.
Claim 15
Dependent Claim
21 words
A compound according to claim 1, wherein -Y-A is 2-CH =CHCOOH, X is =CH-, n is 2 and Z is dimethylamino.
Claim 16
Dependent Claim
21 words
I6. A compound according to claim I, wherein -Y-A is 2-COOH, X is =CH-, n is 2 and Z is methylamino.
Claim 17
Dependent Claim
21 words
A compound according to claim I, wherein -Y-A is 2-COOH, X is = CH-, n is 2 and Z is amino.
Claim 18
Dependent Claim
23 words
A pharmaceutical composition comprising a pharmaceutical carrier and as an active ingredient, an effective amount of a dibenz[b,e]oxepin compound defined in claim I.
Claim 19
Dependent Claim
15 words
A pharmaceutical composition according to claim 18, wherein said compound is defined in claim 6.
References Cited (Backward Citations)
No citation records indexed.
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