EP0235301A1
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EP
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Pyridopyrimidine nucleotide derivatives
Assignee: Teijin Ltd
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Filing: 1986-08-28
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Granted: —
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Expires: 2006-08-28
Abstract
Abstract Pyridopyrimidine nucleotide derivatives represented by general formula (I), (wherein X 1 and Y 1 each represents formula (ii), (wherein n represents an integer of 0, 1, 2 or 3 provided that n in Xi and in Yi do not represent 0 at the same time), Z represents a hydrogen atom or formula (III), (wherein m represents an integer of 0, 1, 2 or 3), Wi represents a hydrogen atom or a hydroxy group, R 2 represents a single bond between the 7-position carbon atom and the 8-position nitrogen atom when Ri represents an amino group or halogen, and Ri represents a carbonyl bond (C=O) together with the 7-position carbon atom when R 2 represents hydrogen or a lower alkyl group) and oligo- or polynucleotides containing at least one such moiety within, or at a terminal of, the molecule are disclosed. They are fluorescent and can form a base pair with guanidine or adenine.
Inventors
- 👤 Hideo 1348-39 Nishi 16-Chome Inoue
- 👤 Eiko 1422-1 Nishi 18-Chome Ohtsuka
- 👤 Akihiro 22 Nishi 5-Chome Imura
- 👤 Kenichi 5-18 Tamadaira 3-Chome Masuda
- 👤 Takashi 30-1 Toyoda 2-Chome Kamimura
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-06 03:12
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/10; C07H21/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
136 words
Pyridopyrimidine nucleotide derivatives expressed by formula (I): wherein X 1 and Y 1 respectively represent (in which n indicates an integer of 0, 1, 2, or 3; however, in no case X 1 and Y 1 both indicate n=O); Z 1 indicates a hydrogen atom or (in which m indicates an integer of 1, 2, or 3); W 1 indicates a hydrogen atom or a hydroxyl group. As for R 1 and R 2 in case where R 1 is an amino group or halogen, R 2 indicates a single bond between the carbon atom at the 7-position and the nitrogen atom at the 8-position, and in case where R 2 is a hydrogen atom or a lower alkyl group, R 1 indicates a carbonyl bond ( C=O) formed with the carbon atom at the 7-position.
Claim 2
Dependent Claim
136 words
Pyridopyrimidine nucleotide derivatives expressed by formula (I): wherein X 1 and Y 1 respectively represent (in which n indicates an integer of 0, 1, 2, or 3; however, in no case X 1 and Y 1 both indicate n=O); Z 1 indicates a hydrogen atom or (in which m indicates an integer of 1, 2, or 3); W 1 indicates a hydrogen atom or a hydroxyl group. As for R 1 and R 2 in case where R 1 is an amino group or halogen, R 2 indicates a single bond between the carbon atom at the 7-position and the nitrogen atom at the 8-position, and in case where R 2 is a hydrogen atom or a lower alkyl group, R 1 indicates a carbonyl bond ( C=O) formed with the carbon atom at the 7-position.
Claim 3
Dependent Claim
45 words
Pyridopyrimidine nucleotide derivatives according to Claim 1, wherein X 1 and/or Y 1 represent (in which n indicates an integer of 1, 2, or 3); Z 1 indicates a hydrogen aton or a hydroxyl group; and W 1 indicates a hydrogen atom in formula (I).
Claim 4
Dependent Claim
178 words
Oligo- or polynucleotides, which have at least one pyridopyrimidine nucleotide derivative unit expressed by formula (II) in their molecules or at their molecular terminals. wherein X 2 indicates either and in case where X 2 is Y 2 or Z 2 indicates -O- (while the other indicates a hydrogen atom or hydroxyl group), and in case where X 2 is Y 2 or Z 2 indicates -O- or (while the other indicates a hydrogen atom or hydroxyl group), (wherein r indicates an integer of 0, 1, 2, or 3 and s indicates an integer of 1, 2, or 3). W 2 indicates a hydrogen atom or hydroxyl group. As for R 1 and R 2 , in case where R 1 is an amino group or halogen, R 2 indicates a single bond between the carbon atom at the 7-position and the nitrogen atom at the 8- position, and in case where R 2 is a hydrogen atom or a lower alkyl group, R 1 indicates a carbonyl bond (C\=O) formed with the carbon atom at the 7-position.
Claim 5
Dependent Claim
178 words
Oligo- or polynucleotides, which have at least one pyridopyrimidine nucleotide derivative unit expressed by formula (II) in their molecules or at their molecular terminals. wherein X 2 indicates either and in case where X 2 is Y 2 or Z 2 indicates -O- (while the other indicates a hydrogen atom or hydroxyl group), and in case where X 2 is Y 2 or Z 2 indicates -O- or (while the other indicates a hydrogen atom or hydroxyl group), (wherein r indicates an integer of 0, 1, 2, or 3 and s indicates an integer of 1, 2, or 3). W 2 indicates a hydrogen atom or hydroxyl group. As for R 1 and R 2 , in case where R 1 is an amino group or halogen, R 2 indicates a single bond between the carbon atom at the 7-position and the nitrogen atom at the 8- position, and in case where R 2 is a hydrogen atom or a lower alkyl group, R 1 indicates a carbonyl bond (C\=O) formed with the carbon atom at the 7-position.
Claim 6
Dependent Claim
26 words
Oligo- or polynucleotides according to Claim 3, wherein X 2 is and Y 2 is -O-, and W 2 is a hydrogen atom in formula (II).
References Cited (Backward Citations)
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