EP0232884A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Diafiltration apparatus
Assignee: EMD Millipore Corp
•
Filing: 1987-02-09
•
Granted: —
•
Expires: 2007-02-09
Abstract
Abstract A process and apparatus is provided for separating whole blood from a patient into a cellular component and a plasma component and for separating the plasma component into a high molecular weight plasma fraction and a low molecular weight plasma fraction and wherein anticoagulant is added to the whole blood and a physiologically acceptable liquid diluent is added to the plasma component. The rate of addition of the diluent is governed by the following equation:
Inventors
- 👤 Anthony J. Dileo
- 👤 Gaston De Los Reyes
- 👤 Lisa M. Waranch
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-30 22:51
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/34; A61M1/3472; A61M1/3482; A61M2205/00; A61M2205/75; A61M2205/7563
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
190 words
Apparatus for separating whole blood into a cellular component and a plasma component and for separating said plasma components into a high molecular weight plasma fraction and a low molecular weight plasma fraction which comprises: a) means for withdrawing whole blood from a patient, b) means for continuously introducing anticoagulant into said whole blood, c) means for passing the mixture of whole blood and anticoagulant into a first separator means adapted to separate whole blood to form a cellular component and a plasma component, d) means for adding a physiologically acceptable liquid diluent to said plasma component at a diluent flow rate defined by Equation l to form a mixture of said diluent and said plasma component, e) means for separating said mixture of diluent and plasma component utilizing a membrane into a high molecular weight plasma fraction and a low molecular weight plasma fraction, f) means for recycling at least a portion of said high molecular weight fraction to be admixed with said mixture of diluent and said plasma component, and g) and means for recycling said cellular component and said low molecular weight plasma component to said patient.
Claim 2
Dependent Claim
190 words
Apparatus for separating whole blood into a cellular component and a plasma component and for separating said plasma components into a high molecular weight plasma fraction and a low molecular weight plasma fraction which comprises: a) means for withdrawing whole blood from a patient, b) means for continuously introducing anticoagulant into said whole blood, c) means for passing the mixture of whole blood and anticoagulant into a first separator means adapted to separate whole blood to form a cellular component and a plasma component, d) means for adding a physiologically acceptable liquid diluent to said plasma component at a diluent flow rate defined by Equation l to form a mixture of said diluent and said plasma component, e) means for separating said mixture of diluent and plasma component utilizing a membrane into a high molecular weight plasma fraction and a low molecular weight plasma fraction, f) means for recycling at least a portion of said high molecular weight fraction to be admixed with said mixture of diluent and said plasma component, and g) and means for recycling said cellular component and said low molecular weight plasma component to said patient.
Claim 3
Independent Claim
24 words
The apparatus of claim l wherein said high molecular weight fraction and said mixture of diluent and plasma component are admixed in a reservoir.
Claim 4
Independent Claim
31 words
The apparatus of claim l wherein said plasma component is separated into a high molecular weight plasma fraction and a low molecular weight plasma fraction by means of an ultrafiltration membrane.
Claim 5
Independent Claim
42 words
The apparatus of claim l wherein pumps are provided down stream of said first separation means, and said means for separating the mixture of diluent and plasma component into a high molecular weight plasma fraction and a low molecular weight plasma fraction.
Claim 6
Dependent Claim
174 words
The process for separating whole blood into a cellular component and a plasma component and for separating said plasma component into a high molecular weight plasma fraction and a low molecular weight plasma fraction which comprises: a) withdrawing whole blood from a patient, b) continuously introducing anticoagulant into whole blood, c) passing the mixture of whole blood and anticoagulant through a first separating means adapted to separating whole blood to form a cellular component and a plasma component, d) adding a physiologically acceptable liquid diluent to said plasma component at a diluent flow rate defined by Equation l: thereby to form a mixture of said diluent and said plasma component, e) separating said mixture of diluent and said plasma component into a high molecular weight plasma fraction and a low molecular weight plasma fraction, f) recycling at least a portion of said high molecular weight fraction to the admix with said mixture of diluent and said plasma component, and g) recycling said cellular component and said low molecular weight plasma component to said patient.
Claim 7
Dependent Claim
174 words
The process for separating whole blood into a cellular component and a plasma component and for separating said plasma component into a high molecular weight plasma fraction and a low molecular weight plasma fraction which comprises: a) withdrawing whole blood from a patient, b) continuously introducing anticoagulant into whole blood, c) passing the mixture of whole blood and anticoagulant through a first separating means adapted to separating whole blood to form a cellular component and a plasma component, d) adding a physiologically acceptable liquid diluent to said plasma component at a diluent flow rate defined by Equation l: thereby to form a mixture of said diluent and said plasma component, e) separating said mixture of diluent and said plasma component into a high molecular weight plasma fraction and a low molecular weight plasma fraction, f) recycling at least a portion of said high molecular weight fraction to the admix with said mixture of diluent and said plasma component, and g) recycling said cellular component and said low molecular weight plasma component to said patient.
Claim 8
Dependent Claim
29 words
The process of claim 5 wherein l00 percent of the high molecular weight plasma fraction is recycled to be admixed with said mixture of diluent and said plasma component.
Claim 9
Dependent Claim
36 words
The process of claim 5 wherein said plasma component is separated into a high molecular weight plasma fraction and a low molecular weight plasma fraction by passing said plasma component into contact with an ultrafiltration membrane.
Claim 10
Dependent Claim
36 words
The process of claim 5 wherein the rate of addition of said liquid diluent is at least partially controlled by recycling between about 50-60 percent of the albumin in the original whole blood to the patient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.