EP0231826A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Theophylline sustained release tablet
Assignee: Farvalsa AG
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Filing: 1987-01-23
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Granted: —
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Expires: 2007-01-23
Abstract
Abstract Compressed tablets from which theophylline is released at a steady rate with twelve hour dosing intervals are disclosed. The tablets contain 43 to 50 weight percent theophylline; 10 to 20 weight percent water insoluble polymer; 10 to l5 weight percent of a polymer selected from the group consisting of water soluble polymers and hydrophilic gel formers which swell in water; and 5 to l5 weight percent acid insoluble polymer having carboxylic groups. The tablet may additionally contain 5 to 9 weight percent hydrophobic lubricant. A preferred composition contains: 43 to 50 weight percent theophylline; 10 to 20 weight percent polyvinyl acetate; 10 to l5 weight percent polyvinylpyrrolidine; 5 to l5 weight percent cellulose acetate phthalate and optionally contains 5 to 7 weight percent of a lubricant mixture containing stearic acid, magnesium stearate and talc.
Inventors
- 👤 Aracelis M. Avenida Universitaria Ortega
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-06 10:07
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61K9/2077; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61K31/519; A61K31/52; A61K9/2004; A61K9/2022; A61K9/2027; A61K9/205; A61K9/2054
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
59 words
A pharmaceutical tablet comprising: a) 43 to 50 weight percent theophylline; b) l0 to 20 weight percent water insoluble polymer; c) l0 to l5 weight percent of a polymer selected from the group consisting of water soluble polymers and hydrophilic gel formers which swell in water; and d) 5 to l5 weight percent acid insoluble polymer having carboxylic groups.
Claim 2
Dependent Claim
59 words
A pharmaceutical tablet comprising: a) 43 to 50 weight percent theophylline; b) l0 to 20 weight percent water insoluble polymer; c) l0 to l5 weight percent of a polymer selected from the group consisting of water soluble polymers and hydrophilic gel formers which swell in water; and d) 5 to l5 weight percent acid insoluble polymer having carboxylic groups.
Claim 3
Dependent Claim
38 words
The pharmaceutical tablet of Claim l wherein the water insoluble polymer is selected from the group consisting of polyvinyl acetate, polyvinyl alcohol, vinyl chloride/vinyl acetate copolymers, acrylate and methacrylate polymers and copolymers, and ethyl and methyl methacrylate copolymers.
Claim 4
Dependent Claim
12 words
The pharmaceutical tablet of Claim l wherein the polymer is polyvinyl acetate.
Claim 5
Dependent Claim
27 words
The pharmaceutical tablet of Claim l wherein the water soluble polymer or gel former is selected from the group consisting of polyvinylpyrrolidone, hydroxypropylcellulose, methylcellulose and sodium carboxymethylcellulose.
Claim 6
Dependent Claim
13 words
The pharmaceutical tablet of Claim l wherein the hydrophilic gel former is polyvinylpyrrolidone.
Claim 7
Dependent Claim
32 words
The pharmaceutical tablet of Claim l wherein the acid insoluble polymer is selected from the group consisting of cellulose acetate phthalate, hydroxypropylmethyl cellulose phthalate and esters of acrylic and methacrylic acid copolymers.
Claim 8
Dependent Claim
15 words
The pharmaceutical tablet of Claim l wherein the acid insoluble polymer is cellulose acetate phthalate.
Claim 9
Dependent Claim
15 words
The pharmaceutical tablet of Claim l further comprising 5 to 9 weight percent hydrophobic lubricant.
Claim 10
Dependent Claim
29 words
The pharmaceutical tablet of Claim 8 wherein the lubricant is selected from the group consisting of talc, fatty acids, salts of fatty acids, mineral oil and hydrogenated vegetable oils.
Claim 11
Dependent Claim
14 words
l0. The pharmaceutical tablet of Claim 8 wherein the fatty acid is stearic acid.
Claim 12
Dependent Claim
26 words
The pharmaceutical tablet of Claim 9 wherein the lubricant comprises: a) 3 parts stearic acid; b) 0.5 part magnesium stearate; and c) l.0 part talc USP.
Claim 13
Dependent Claim
39 words
The pharmaceutical tablet of Claim l comprising: a) 43 to 50 weight percent theophylline; b) l0 to 20 weight percent polyvinyl acetate; c) l0 to l5 weight percent polyvinylpyrrolidine; and d) 5 to l5 weight percent cellulose acetate phthalate.
Claim 14
Dependent Claim
36 words
The pharmaceutical tablet of Claim l comprising: a) 50 weight percent theophylline; b) l5 weight percent polyvinylacetate; c) l5 weight percent polyvinyl pyrrolidone: d) l5 weight percent cellulose acetate phthalate; and e) 5 weight percent lubricant.
Claim 15
Independent Claim
91 words
A method of maintaining relatively uniform blood levels of theophylline in a host comprising a) formulating a theophylline tablet containing (i) 43 to 50 weight percent theophylline; (ii) l0 to 20 weight percent water insoluble polymer; (iii) l0 to l5 weight percent of a polymer selected from the group consisting of water soluble polymers and hydrophilic gel formers which swell in water; and (iv) 5 to l5 weight percent acid insoluble polymer having carboxylic groups. b) orally administering one or more of said tablets to a host at twelve hour intervals.
Claim 16
Independent Claim
91 words
A method of maintaining relatively uniform blood levels of theophylline in a host comprising a) formulating a theophylline tablet containing (i) 43 to 50 weight percent theophylline; (ii) l0 to 20 weight percent water insoluble polymer; (iii) l0 to l5 weight percent of a polymer selected from the group consisting of water soluble polymers and hydrophilic gel formers which swell in water; and (iv) 5 to l5 weight percent acid insoluble polymer having carboxylic groups. b) orally administering one or more of said tablets to a host at twelve hour intervals.
Claim 17
Independent Claim
74 words
The method of Claim l4 wherein the tablet is formulated by: a) wet granulating a mixture of the theophylline and the acid insoluble polymer with an alcoholic solution containing part of the hydrophilic gel former or water soluble polymer; b) mixing the remaining hydrophilic gel former or water soluble polymer with the water insoluble polymer; c) mixing the compositions resulting from (a) and (b); and d) comprising the mixture resulting from (d) into tablets.
Claim 18
Independent Claim
21 words
The method of Claim l5 wherein 5 to 9 weight percent hydrophobic lubricant is added to the mixture prior to compression.
References Cited (Backward Citations)
No citation records indexed.
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