EP0229504A2
Expired / Lapsed
EP
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System, apparatus and method of continuously fractionating blood in situ
Assignee: Individual
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Filing: 1986-12-15
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Granted: —
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Expires: 2006-12-15
Abstract
Abstract A system (300), method and device (25) for continuously fractionating blood in situ. The fractionating device (25) is connected in a closed loop to the donor (30) and includes interleaved blood plates (55) and blood fraction plates (50) separated by a semipermeable membrane (75). Grooves (95) in the plates direct blood flow and blood fraction collection. Uniform distribution among the plates (50,55) and intraplate (60) is obtained by manifolds (110). The input and output pressures of the blood pump (308) are sensed and inputed to an microprocessor (301), into which donor data including weight, sex, and hematocrit is also keyed by the user. The microprocessor operates under program control to calculate, based on the donor data, the amount of plasma to be collected and the amount of anti- coagulant to be added. The program controls the operation of the extracorporeal devices, regulates the operating parameters, and stops the procedure when the predetermined amount of plasma has been obtained.
Inventors
- 👤 Ardis R. Lavender
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-30 07:16
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/34; A61M1/3496; B; B01; B01D; B01D61/00; B01D61/14; B01D61/147; B01D61/18; B01D61/22; B01D63/00; B01D63/08; B01D63/082; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0415; A61M2230/00; A61M2230/20; A61M2230/207
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
46 words
A method of separating a blood substance from a source of blood, comprising: ascertaining the initial amount of the substance in the blood source, and separating the substance from the blood source until a predetermined percentage of the initial amount of the substance has been separated.
Claim 2
Independent Claim
46 words
A method of separating a blood substance from a source of blood, comprising: ascertaining the initial amount of the substance in the blood source, and separating the substance from the blood source until a predetermined percentage of the initial amount of the substance has been separated.
Claim 3
Dependent Claim
15 words
The method of claim 1, wherein the substance is separated from the blood source continuously.
Claim 4
Dependent Claim
27 words
The method of claim 1, wherein the substance is plasma, and wherein the initial plasma volume is automatically ascertained based on blood hematocrit and blood volume values.
Claim 5
Dependent Claim
32 words
The method of claim 1, wherein the blood source is a human, and further comprising extracting blood from the human, and returning to the human the portion of the blood not separated.
Claim 6
Dependent Claim
32 words
The method of claim 3, wherein the plasma is separated from the blood source in a series- of batch operations until the predetermined percentage of the initial plasma volume has been separated.
Claim 7
Independent Claim
63 words
A method of continuously collecting plasma from a human donor thereof, comprising: ascertaining the donor's initial plasma volume, passing at least a portion of the donor's blood through a device (310) connected to the donor for continuously removing a portion of the plasma present in the blood until a predetermined portion of the donor's initial plasma volume has been removed from the donor.
Claim 8
Independent Claim
63 words
A method of continuously collecting plasma from a human donor thereof, comprising: ascertaining the donor's initial plasma volume, passing at least a portion of the donor's blood through a device (310) connected to the donor for continuously removing a portion of the plasma present in the blood until a predetermined portion of the donor's initial plasma volume has been removed from the donor.
Claim 9
Dependent Claim
28 words
The method of claim 6, wherein the device is serially connected to the donor and the blood flows between the donor and the device in a closed loop.
Claim 10
Dependent Claim
40 words
The method of claim 6, wherein the predetermined portion is in the range of from about 16 % by volume to about 20% by volume of the donor's initial plasma volume and is substantially the same for each donor thereof.
Claim 11
Dependent Claim
44 words
The method of claim 6, and further comprising sensing the amount of plasma removed from the donor until .the prede,termined portion of the initial plasma volume has been removed and thereafter stopping the removal of plasma in response to the amount of plasma collected.
Claim 12
Dependent Claim
20 words
The method of claim 9, wherein the plasma volume is sensed by continuously weighing the plasma separated from the donor.
Claim 13
Independent Claim
50 words
A method of diluting a blood substance in a source of blood, comprising: ascertaining the initial amount of the substance in the blood source, and adding a diluent to the blood in an amount equal to a predetermined percentage of the initial amount of the substance in the blood source.
Claim 14
Independent Claim
50 words
A method of diluting a blood substance in a source of blood, comprising: ascertaining the initial amount of the substance in the blood source, and adding a diluent to the blood in an amount equal to a predetermined percentage of the initial amount of the substance in the blood source.
Claim 15
Dependent Claim
17 words
The method of claim 11, wherein the blood substance is plasma and the diluent includes an anticoagulant.
Claim 16
Dependent Claim
52 words
The method of claim 11, wherein the source of blood is a human being and the blood is circulating in a closed loop to and from the human being during the addition of diluent to the blood, and further comprising passing the blood through an extracorporeal (310) device in the closed loop.
Claim 17
Dependent Claim
27 words
The method of claim 12, wherein the initial amount is the plasma concentration in the blood and is automatically ascertained from blood hematocrit and blood volume values.
Claim 18
Dependent Claim
28 words
The method of claim 14, wherein the volume ratio of anticoagulant to plasma in the blood is maintained in the range of from about 0.40 to about 0.50.
Claim 19
Independent Claim
66 words
A method of collecting plasma from a human donor thereof, comprising: ascertaining the donor's initial plasma volume, introducing anticoagulant to the blood from which the plasma is to be collected in an amount which is a predetermined percentage of the plasma in the blood, separating plasma from the blood, and collecting the separated plasma until a predetermined portion of the initial plasma volume has been collected.
Claim 20
Independent Claim
66 words
A method of collecting plasma from a human donor thereof, comprising: ascertaining the donor's initial plasma volume, introducing anticoagulant to the blood from which the plasma is to be collected in an amount which is a predetermined percentage of the plasma in the blood, separating plasma from the blood, and collecting the separated plasma until a predetermined portion of the initial plasma volume has been collected.
Claim 21
Dependent Claim
31 words
The method of claim 16, wherein plasma is separated from the blood continuously, and anticoagulant is introduced into the blood only so long as plasma is being separated from the blood.
Claim 22
Dependent Claim
28 words
The method of claim 17, wherein the anticoagulant flow is a function of blood flow and wherein the anticoagulant is introduced into the blood in a batch process.
Claim 23
Dependent Claim
44 words
The method of claim 16, wherein the anticoagulant is present in the range of from about 40% to about 50% by volume of the plasma volume in the blood and wherein the ratio of anticoagulant to plasma is maintained substantially constant for each donor.
Claim 24
Independent Claim
54 words
A system (300) for separating a blood substance from a source of blood, comprising means (301,309) for ascertaining the volume of the substance in the source of the blood, and means (310) for separating the substance from the blood source until a predetermined percentage of the initial amount of the substance has been separated.
Claim 25
Independent Claim
54 words
A system (300) for separating a blood substance from a source of blood, comprising means (301,309) for ascertaining the volume of the substance in the source of the blood, and means (310) for separating the substance from the blood source until a predetermined percentage of the initial amount of the substance has been separated.
Claim 26
Dependent Claim
50 words
The system of claim 20, wherein said ascertaining means includes processing means (301) operating under stored program control, and further comprising means (301,429) for measuring the amount of the substance which has been separated, and means (301,430) responsive to said measuring means for controlling the operation of said separating means.
Claim 27
Independent Claim
67 words
A system (300) for collecting plasma from a source of blood, comprising means (301) for ascertaining the volume of plasma in the source of blood, and means (310) for separating a predetermined portion of the plasma from the source of blood, said means for ascertaining the volume of plasma in the blood including means (301,429) for automatically calculating the plasma volume from hematocrit and blood volume values.
Claim 28
Independent Claim
67 words
A system (300) for collecting plasma from a source of blood, comprising means (301) for ascertaining the volume of plasma in the source of blood, and means (310) for separating a predetermined portion of the plasma from the source of blood, said means for ascertaining the volume of plasma in the blood including means (301,429) for automatically calculating the plasma volume from hematocrit and blood volume values.
Claim 29
Dependent Claim
86 words
The system of claim 22, wherein said means (310) for separating plasma from the blood includes a device (25) connected in a closed blood loop with the blood source for continuously passing blood through the device while separating plasma from the blood, said means for separating plasma from the blood including a blood pump (30 8 ) serially connected to the device, and means (301,430) for controlling the blood pump to deactivate same when the predetermined portion of plasma has been separated from the blood source.
Claim 30
Dependent Claim
79 words
The system of claim 23, and further means for introducing anticoagulant to the blood including an anticoagulant source (307), a pump (306) for pumping anticoagulant from said anticoagulant source into the closed loop, and means (301,429) for controlling operation of the blood pump and the anticoagulant pump to deactivate same when the predetermined portion of plasma has been separated from the blood source, and means (301,413,414) for maintaining the blood flow rate and the anticoagulant flow rate substantially constant.
Claim 31
Independent Claim
188 words
A system (300) of continuously collecting blood plasma from a donor thereof, comprising processing means (301) including means for ascertaining the initial volume of plasma in the donor based on donor specific data, conduit means (310) defining a closed blood loop with the donor, said conduit means including separating means (25) for continuously separating a portion of the plasma in the donor's blood flowing therethrough; pump means (308) for circulating the blood from the donor through said separating means in the closed loop; means (306,307) for introducing anticoagulant from a source thereof to said conduit means in an amount sufficient to maintain the anticoagulant concentration within a predetermined percentage range of the plasma concentration in the blood flowing into said separation means, container means (325) coupled to said separating means for collecting plasma separated thereby; and measuring means (309) coupled to said container means for determining the amount of plasma collected therein; said processing means including control means (301,430) responsive to the amount of plasma collected for deactivating said pump means and said anticoagulant introducing means when a predetermined percentage of the donor's plasma volume has been collected.
Claim 32
Independent Claim
188 words
A system (300) of continuously collecting blood plasma from a donor thereof, comprising processing means (301) including means for ascertaining the initial volume of plasma in the donor based on donor specific data, conduit means (310) defining a closed blood loop with the donor, said conduit means including separating means (25) for continuously separating a portion of the plasma in the donor's blood flowing therethrough; pump means (308) for circulating the blood from the donor through said separating means in the closed loop; means (306,307) for introducing anticoagulant from a source thereof to said conduit means in an amount sufficient to maintain the anticoagulant concentration within a predetermined percentage range of the plasma concentration in the blood flowing into said separation means, container means (325) coupled to said separating means for collecting plasma separated thereby; and measuring means (309) coupled to said container means for determining the amount of plasma collected therein; said processing means including control means (301,430) responsive to the amount of plasma collected for deactivating said pump means and said anticoagulant introducing means when a predetermined percentage of the donor's plasma volume has been collected.
Claim 33
Dependent Claim
15 words
The system of claim 25, wherein the donor specific data includes body weight and hematocrit.
Claim 34
Dependent Claim
67 words
The system of claim 25, and further comprising sensing means (316,319,320,321) for ascertaining the pressures at the inputs of said pump means and said separating means, said processing means including means (301,407,413) responsive to said sensing means for controlling the operation of said pump means and said anticoagulant introducing means, and means for maintaining the anticoagulant flow rate as a predetermined function of the plasma flow rate.
Claim 35
Dependent Claim
59 words
The system of claim 27, wherein said stored program is menu driven, and further comprising display means (303) coupled to said processing means for displaying menu messages and replies thereto, and input means coupled to said processing means for communicating thereto user replies to the menu messages, said input means (302) supplying donor specific data to said processing means.
Claim 36
Dependent Claim
18 words
The system of claim 25, wherein the system has a total blood volume of less than 25 ml.
Claim 37
Independent Claim
85 words
A system for automatically collecting plasma from blood from a human source based on source specific data, comprising: operating means for handling the blood and collecting the plasma therefrom, processing means, input means coupled to said processing means for selectively transmitting thereto information including the source specific data, and output means coupled to said processing means for receiving and displaying information therefrom, said processing means including control means for automatically controlling the operation of said operating means as a function of the source specific data.
Claim 38
Independent Claim
85 words
A system for automatically collecting plasma from blood from a human source based on source specific data, comprising: operating means for handling the blood and collecting the plasma therefrom, processing means, input means coupled to said processing means for selectively transmitting thereto information including the source specific data, and output means coupled to said processing means for receiving and displaying information therefrom, said processing means including control means for automatically controlling the operation of said operating means as a function of the source specific data.
References Cited (Backward Citations)
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