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EP0229016A2
Expired / Lapsed
EP
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Interleukin-2 compositions
Assignee: Shionogi and Co Ltd
•
Filing: 1987-01-05
•
Granted: —
•
Expires: 2007-01-05
Abstract
Abstract Described are stable interleukin-2 compositions containing serum albumin and showing a pH of 6.1 to 9 in a state of solution, which are useful in the treatment of various cancers or immunodeficiency diseases.
Inventors
- 👤 David R. Thatcher
- 👤 Kazuhiro Shima
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-06 04:51
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/20; A61K38/2013; A61P; A61P37/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
19 words
An interleukin-2 composition containing serum albumin and showing a pH of 6.1 to 9 in a state of solution.
Claim 2
Dependent Claim
19 words
An interleukin-2 composition containing serum albumin and showing a pH of 6.1 to 9 in a state of solution.
Claim 3
Dependent Claim
67 words
A composition as claimed in Claim 1, which is prepared by adjusting a solution of interleukin-2 to a pH of 8 - 11 with a base and immediately thereafter to a pH of 6.1 - 9 with an acid; or by adjusting said solution to a pH of 2 - 6 with an acid and immediately thereafter to a pH of 6.1 - 9 with a base.
Claim 4
Dependent Claim
67 words
A composition as claimed in Claim 2, which is prepared by adjusting a solution of interleukin-2 to a pH of 9 - 11 with a base and immediately thereafter to a pH of 6.1 - 9 with an acid; or by adjusting said solution to a pH of 2 - 4 with an acid and immediately thereafter to a pH of 6.1 - 9 with a base.
Claim 5
Dependent Claim
19 words
A composition as claimed in any of Claims 1 to 3, wherein said serum albumin is human serum albumin.
Claim 6
Dependent Claim
14 words
A composition as claimed in Claim 4, further containing a sugar and/or sugar alcohol.
Claim 7
Dependent Claim
15 words
A composition as claimed in any of Claims 4 and 5, further containing a surfactant.
Claim 8
Dependent Claim
44 words
A composition as claimed in any of Claims 2 and 3, wherein (a) the base is N-methyl-glucamine, monoethanolamine, diethanolamine, triethanolamine or arginine, or a mixture thereof, and (b) the acid is citric acid, tartaric acid, lactic acid or phosphoric acid, or a mixture thereof.
Claim 9
Dependent Claim
18 words
A composition as claimed in any of Claims 1 to 7, in the form of a freeze-dried preparation.
References Cited (Backward Citations)
No citation records indexed.
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