EP0228223A2
Expired / Lapsed
EP
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Non-irritating suprofen solution
Assignee: Cilag AG
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Filing: 1986-12-15
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Granted: —
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Expires: 2006-12-15
Abstract
Abstract A non-irritating aqueous suprofen solution containing essential oils and being suitable for drop application, is described.
Inventors
- 👤 Fritz Henri Boller
- 👤 Roland Rudolph Niederer
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-03 05:08
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/38; A61K47/00; A61K47/44; A61P; A61P25/00; A61P25/04; A61P29/00
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
82 words
An aqueous peroral composition especially suitable for drop application,comprising : a) about 2 to 30% by weight of suprofen, b) about 0.3 to 5% by weight of a water soluble, non-toxic base; c) about 0.1 to 20% by weight of at least one pharmaceutically acceptable essential oil; and d) about 2 to 70% by weight of a solubilizing agent for rendering said essential oil soluble in said aqueous composition,with the proviso that said composition comprises at least 10% by weight of water.
Claim 2
Dependent Claim
82 words
An aqueous peroral composition especially suitable for drop application,comprising : a) about 2 to 30% by weight of suprofen, b) about 0.3 to 5% by weight of a water soluble, non-toxic base; c) about 0.1 to 20% by weight of at least one pharmaceutically acceptable essential oil; and d) about 2 to 70% by weight of a solubilizing agent for rendering said essential oil soluble in said aqueous composition,with the proviso that said composition comprises at least 10% by weight of water.
Claim 3
Dependent Claim
12 words
The composition of claim 1, in which said essential oil contains anethol.
Claim 4
Dependent Claim
19 words
The composition of claim 1 or claim 2, in which said essential oil comprises anise oil or fennel oil.
Claim 5
Dependent Claim
18 words
The composition of claim 1, in which said essential oil comprises clove oil, cinammon oil or citrus oil.
Claim 6
Dependent Claim
19 words
The composition of any one of claims 1 to 4, in which the pH is between 5 and 9.
Claim 7
Dependent Claim
14 words
The composition of claim 5, in which the pH is between 6 and 8.
Claim 8
Dependent Claim
24 words
The composition of any one of claims 1 to 6, in which the said essential oil comprises about 0.5 to 5% by weight thereof.
Claim 9
Dependent Claim
18 words
The composition of any one of claims 1 to 7, wherein said solubilizing agent comprises an organic solvent.
Claim 10
Dependent Claim
17 words
The composition of any one of claims 1 to 7, wherein said solubilizing agent comprises a surfactant.
Claim 11
Dependent Claim
16 words
The composition of any of claims 1 to 7, wherein said solubilizing agent comprises propylene glycol.
Claim 12
Dependent Claim
24 words
ll.The composition of any one of claims 1 to 7, wherein said solubilizing agent comprises a mixture of an organic solvent and a surfactant.
Claim 13
Dependent Claim
14 words
The composition of claim 8 or claim 11, wherein said organic solvent comprises ethanol.
Claim 14
Dependent Claim
14 words
The composition of claim 9 or claim 11,wherein said solubilizing agent comprises polysorbate 80.
Claim 15
Dependent Claim
38 words
A pharmaceutical composition, useful for adults as an analgesic in unit peroral dosage form, comprising about 1 ml of the composition of any one of claims 1 to 13, said composition containing about 20% by weight of suprofen.
Claim 16
Dependent Claim
16 words
The composition of claim 14, said composition including sodium hydroxide, anise oil,Polysorbate 80,ethanol and propylene glycol.
Claim 17
Dependent Claim
38 words
A pharmaceutical composition, useful for children as an analgesic in unit peroral dosage form, comprising about 1 ml of the composition of any one of claims 1 to 13, said compostion containing about 10% by weight of suprofen.
Claim 18
Dependent Claim
17 words
The composition of claim 15, said composition including sodium hydroxide, anise oil, Polysorbate 20, and Poloxamer 407.
Claim 19
Independent Claim
89 words
A method for producing a composition according to any one of claims 1 to 17 comprising mixing together: a) about 2 to 30% by weight of suprofen, b) about 0.3 to 5% by weight of a water soluble, non-toxic base; c) about 0.1 to 20% by weight of at least one pharmaceutically acceptable essential oil; and d) about 2 to 70% by weight of a solubilizing agent for rendering said essential oil soluble in said aqueous composition. to form a composition comprising at least 10% by weight of water.
References Cited (Backward Citations)
No citation records indexed.
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