EP0226884A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
System for the controlled-rate release of active substances
Assignee: Jagotec AG
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Filing: 1986-12-01
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Granted: —
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Expires: 2006-12-01
Abstract
Abstract A system for the controlled-rate release of active substances, consisting of: a) a deposit-core comprising the active substance and having defined geometric form; b) a support-platform applied to said deposit-core. Said deposit-core contains, mixed with the active substance, a polymeric material having a high degree of swelling on contact with water or aqueous liquids, a gellable polymeric material, said polymeric materials being replaceable by a single polymeric material having both swelling and gelling properties, and other adjuvants able to provide the mixture with suitable characteristics for its compression and for its intake of water. Said support-platform consists of a polymeric material insoluble in aqueous liquids and partially coating said deposit-core. The intensity and duration of the swelling force of said polymeric material with a high degree of swelling constitutes the primary factor in controlling the release of the active substance.
Inventors
- 👤 Paolo Colombo
- 👤 Aldo La Manna
- 👤 Ubaldo Conte
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-04 05:12
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205; A61K9/2054; A61K9/2027; A61K9/2072; A61K9/2086; A61K9/209
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
113 words
A system for the controlled-rate release of active substances, consisting of: a) a deposit-core comprising the active substance and having defined geometric form, b) a support-platform applied to said deposit-core, characterised in that said deposit-core contains, mixed with the active substance, a polymeric material having a high degree of swelling on contact with water or aqueous liquids, a gellable polymeric material, said polymeric materials being replaceable by a single polymeric material having both swelling and gelling properties, and other adjuvants able to provide the mixture with suitable characteristics for its compression and for its intake of water, said support-platform consisting of a polymeric material insoluble in aqueous liquids and partially coating said deposit-core.
Claim 2
Independent Claim
113 words
A system for the controlled-rate release of active substances, consisting of: a) a deposit-core comprising the active substance and having defined geometric form, b) a support-platform applied to said deposit-core, characterised in that said deposit-core contains, mixed with the active substance, a polymeric material having a high degree of swelling on contact with water or aqueous liquids, a gellable polymeric material, said polymeric materials being replaceable by a single polymeric material having both swelling and gelling properties, and other adjuvants able to provide the mixture with suitable characteristics for its compression and for its intake of water, said support-platform consisting of a polymeric material insoluble in aqueous liquids and partially coating said deposit-core.
Claim 3
Dependent Claim
29 words
A system as claimed in claim 1, characterised in that said deposit-core is obtained by compressing said mixture to a pressure of between 1000 and 4000 kg/cm 2 .
Claim 4
Dependent Claim
40 words
A system as claimed in claim 1, characterised in that said polymeric material with a high degree of swelling comprises cross-linked sodium carboxymethylcellulose, cross-linked hydroxypropylcellulose, high-molecular weight hydroxypropylmethylcellulose, carboxymethylamide, potassium methacrylatedivinyl- benzene copolymer, polymethylmethacrylate, cross-linked polyvinylpyrrolidone and high-molecular weight polyvinylalcohols.
Claim 5
Dependent Claim
29 words
4; A system as claimed in claim 1, characterised in that said gellable polymeric material comprises methylcellulose, carboxymethylcellulose, low-molecular weight hydroxypropylmethylcellulose, low-molecular weight polyvinylalcohols, polyoxyethyleneglycols and non-cross linked polyvinylpyrrolidone.
Claim 6
Dependent Claim
24 words
A system as claimed in claim 1, characterised in that said polymeric material with swelling and gelling properties comprises medium-viscosity hydroxypropylmethylcellulose and medium-viscosity polyvinylalcohols.
Claim 7
Dependent Claim
47 words
A system as claimed in claim 1, characterised in that said polymeric material with a high degree of swelling is between 5 and 80% by weight and said gellable polymeric material is between 90 and 10% by weight with respect to the constituent mixture of the deposit-core.
Claim 8
Dependent Claim
25 words
A system as claimed in claim 1, characterised in that said support-platform is formed by applying said water-insoluble polymeric material to said deposit-core by compression.
Claim 9
Dependent Claim
30 words
A system as claimed in claim 1, characterised in that said support-platform is formed by immersing said deposit-core in a solution of said water-insoluble polymeric material in an organic solvent.
Claim 10
Dependent Claim
33 words
A system as claimed in claim 1, characterised in that said support-platform is formed by spraying said water-insoluble polymeric material in the form of a solution in an organic solvent onto said deposit-core.
Claim 11
Dependent Claim
22 words
A system as claimed in claim 1, characterised in that said support-platform has a thickness of between 10 microns and 2 mm.
Claim 12
Dependent Claim
24 words
A system as claimed in claim 1, characterised in that said support-platform covers from 10 to 90% of the total surface of the system.
Claim 13
Dependent Claim
32 words
A system as claimed in claim 1, characterised in that said polymeric material insoluble in aqueous liquids comprises acrylates, cellulose, ethylcellulose, cellulose acetate-propionate, polyethylene, methacrylates, acrylic acid copolymers and high-molecular weight polyvinylalcohols.
Claim 14
Dependent Claim
40 words
A system as claimed in claim 1, characterised in that the intensity and duration of the swelling force of said polymeric material with a high degree of swelling constitutes the primary control factor for the release of the active substance.
Claim 15
Dependent Claim
32 words
A system as claimed in claim 1, characterised in that the geometry of said support-platform constitutes a further control factor for the release of the active substance and directs the emission thereof.
Claim 16
Dependent Claim
17 words
A system as claimed in claim 1, characterised in that said adjuvants are magnesium stearate and mannitol.
Claim 17
Dependent Claim
38 words
A system as claimed in claim 1, characterised in that said deposit-core is formed from two layers, each of which comprises an active substance, a polymeric material with a high degree of swelling, and a gellable polymeric material.
Claim 18
Dependent Claim
30 words
A system as claimed in claim 1, characterised in that said support-platform is in the form of a coating applied to one flat, convex or concave surface of said deposit-core.
Claim 19
Dependent Claim
30 words
A system as claimed in claim 1, characterised in that said support-platform is in the form of a coating applied to two separate zones of the surface of said deposit-core.
Claim 20
Dependent Claim
30 words
A system as claimed in claim 1, characterised in that said support-platform is in the form of a coating which surrounds said deposit-core, to leave two opposing surface portions free.
Claim 21
Dependent Claim
30 words
,20. A system as claimed in claim 1, characterised in that said support-platform is in the form of a container which encases said deposit-core, to leave one surface portion free.
Claim 22
Dependent Claim
21 words
A system as claimed in claim 1, characterised in that said support-platform covers one half of the surface of said deposit-core
Claim 23
Dependent Claim
35 words
A therapeutic system having a form and structure suitable for the particular method of administration, wherein the dosage unit consists of a number of systems claimed in claims 1 to 21 disposed in one container.
Claim 24
Independent Claim
62 words
A method for preparing a system claimed in claims 1 to 21, characterised in that the mixture containing the active substance and the polymeric materials is wetted with a solution of adjuvants to obtain a granulate which is compressed to obtain the deposit-core, which is then coated over a determined area with a water-insoluble polymeric material possibly dissolved in an organic solvent.
References Cited (Backward Citations)
No citation records indexed.
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