EP0226104A2
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EP
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N-Benzoyl urea compounds, antitumorous compositions containing them, and process for their preparation
Assignee: Ishihara Sangyo Kaisha Ltd
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Filing: 1986-11-28
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Granted: —
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Expires: 2006-11-28
Abstract
Abstract An N-benzoyl urea compound having the formula: wherein X is a hydrogen atom, a halogen atom or a nitro group, n is an integer of from 1 to 3, and Q is wherein Y, is an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Y 2 is a hydrogen atom, a halogen atom, a nitro group, an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Z is a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group, and each of A and B is =CH- or a nitrogen atom, provided that one of A and B is =CH- and the other is a nitrogen atom, with the provisos (1) that when Q is where when X is a hydrogen atom and Y, is an alkyl group, Z is not a hydrogen atom, a halogen atom nor a trifluoromethyl group, and (2) that when Q is wherein A is a nitrogen atom and Y, is a trifluoromethyl group, Y 2 is other than a hydrogen atom.
Inventors
- 👤 Haga Takahiro
- 👤 Yamada Nobutoshi
- 👤 Sugi Hideo
- 👤 Koyanagi Toru
- 👤 Okada Hiroshi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 21:34
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/32; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/62; C07D213/63; C07D213/64; C07D213/643; A; A61; A61P; A61P35/00; C07D237/00; C07D237/02; C07D237/06; C07D237/10; C07D237/14; C07D239/34
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
193 words
An N-benzoyl urea compound having the formula: wherein X is a hydrogen atom, a halogen atom or a nitro group, n is an integer of from 1 to 3, and Q is wherein Y 1 is an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Y 2 is a hydrogen atom, a halogen atom, a nitro group, an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Z is a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group, and each of A and B is = CH - or a nitrogen atom, provided that one of A and B is =CH- and the other is a nitrogen atom, with the provisos (1) that when Q is where when X is a hydrogen atom and Y 1 is an alkyl group, Z is not a hydrogen atom, a halogen atom nor a trifluoromethyl group, and (2) that when Q is wherein A is a nitrogen atom and Y 1 is a trifluoromethyl group, Y 2 is other than a hydrogen atom.
Claim 2
Dependent Claim
193 words
An N-benzoyl urea compound having the formula: wherein X is a hydrogen atom, a halogen atom or a nitro group, n is an integer of from 1 to 3, and Q is wherein Y 1 is an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Y 2 is a hydrogen atom, a halogen atom, a nitro group, an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Z is a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group, and each of A and B is = CH - or a nitrogen atom, provided that one of A and B is =CH- and the other is a nitrogen atom, with the provisos (1) that when Q is where when X is a hydrogen atom and Y 1 is an alkyl group, Z is not a hydrogen atom, a halogen atom nor a trifluoromethyl group, and (2) that when Q is wherein A is a nitrogen atom and Y 1 is a trifluoromethyl group, Y 2 is other than a hydrogen atom.
Claim 3
Dependent Claim
11 words
The N-benzoyl urea compound according to Claim 1, wherein Q is
Claim 4
Dependent Claim
42 words
The N-benzoyl urea compound according to Claim 2, wherein X is a nitrogen atom or a halogen atom, Y i is an alkyl group which may be substituted by halogen, Y 2 is a hydrogen atom, and Z is a halogen atom.
Claim 5
Dependent Claim
11 words
The N-benzoyl urea compound according to Claim 1, wherein Q is
Claim 6
Dependent Claim
37 words
The N-benzoyl urea compound according to Claim 4, wherein Y 2 is an alkyl group which may be substituted by halogen, A is a nitrogen atom, B is = CH -, and Z is a halogen atom.
Claim 7
Dependent Claim
10 words
The compound according to Claim 2, which is N -(2-nitrobenzoyl)-N'-[4-(5-chloro-2-pyrimidinyloxy)-3-methylphenyllurea.
Claim 8
Dependent Claim
10 words
The compound according to Claim 2, which is N -(2-nitrobenzoyl)-N'-[4-(5-bromo-2-pyrimidinyloxy)-3-methylphenyllurea.
Claim 9
Dependent Claim
10 words
The compound according to Claim 4, which is N -(2-nitrobenzoyl)-N'-[3-(5-chloro-2-pyrimidinyloxy)-4-methylphenyllurea.
Claim 10
Dependent Claim
308 words
A process for preparing an N-benzoyl urea compound having the formula: wherein X is a hydrogen atom, a halogen atom or a nitro group, n is an integer of from 1 to 3, and Q is wherein Y 1 is an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Y 2 is a hydrogen atom, a halogen atom, a nitro group, an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Z is a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group, and each of A and B is = CH - or a nitrogen atom, provided that one of A and B is = CH - and the other is a nitrogen atom, with the provisos (1) that when Q is where when X is a hydrogen atom and Y 1 is an alkyl group, Z is not a hydrogen atom, a halogen atom nor a trifluoromethyl group, and (2) that when Q is wherein A is a nitrogen atom and Y 1 is a trifluoromethyl group, Y 2 is other than a hydrogen atom, which comprises reacting a compound having the formula: wherein R 1 is an isocyanate group, an amino group, wherein X, Y 1 , Y 2 and n are as defined above, with a compound having the formula: wherein R 2 is (wherein Y 1 and Y 2 are as defined above, and R 3 is an amino group or an isocyanate group which is different from R 1 ) or a halogen atom, provided that when R 1 is R 2 is a halogen atom, and when R 1 is an isocyanate group or an amino group, R 2 is and A, B and Z are as defined above.
Claim 11
Dependent Claim
308 words
A process for preparing an N-benzoyl urea compound having the formula: wherein X is a hydrogen atom, a halogen atom or a nitro group, n is an integer of from 1 to 3, and Q is wherein Y 1 is an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Y 2 is a hydrogen atom, a halogen atom, a nitro group, an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Z is a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group, and each of A and B is = CH - or a nitrogen atom, provided that one of A and B is = CH - and the other is a nitrogen atom, with the provisos (1) that when Q is where when X is a hydrogen atom and Y 1 is an alkyl group, Z is not a hydrogen atom, a halogen atom nor a trifluoromethyl group, and (2) that when Q is wherein A is a nitrogen atom and Y 1 is a trifluoromethyl group, Y 2 is other than a hydrogen atom, which comprises reacting a compound having the formula: wherein R 1 is an isocyanate group, an amino group, wherein X, Y 1 , Y 2 and n are as defined above, with a compound having the formula: wherein R 2 is (wherein Y 1 and Y 2 are as defined above, and R 3 is an amino group or an isocyanate group which is different from R 1 ) or a halogen atom, provided that when R 1 is R 2 is a halogen atom, and when R 1 is an isocyanate group or an amino group, R 2 is and A, B and Z are as defined above.
Claim 12
Dependent Claim
7 words
The process according to Claim 9, wherein
Claim 13
Dependent Claim
21 words
The process according to Claim 10, wherein R 1 is an isocyanate group or an amino group, and R 2 is
Claim 14
Dependent Claim
7 words
The process according to Claim 9, wherein
Claim 15
Dependent Claim
24 words
1 3 . The process according to Claim 12, wherein R 1 is an isocyanate group or an amino group, and R 2 is
Claim 16
Dependent Claim
23 words
An antitimorous composition comprising a therapeutically effective amount of an N-benzoyl urea compound as defined in Claim 1 and a pharmaceutically acceptable adjuvant.
Claim 17
Dependent Claim
27 words
A method for treating a cancer, which comprises administering a therapeutically effective amount of an N-benzoyl urea compound as defined in Claim 1 to a diseased subject.
References Cited (Backward Citations)
No citation records indexed.
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