2-Substituted-[2-substituted-amino]-N-aralkyl-3-[indol-3-yl]propanamides

Claim 1

BE, CH, DE, FR, GB, IT, LI, LU, NL, SE ) 1. A compound having structural formula 1: wherein A is -NH-, or -(CH2)n, where n is an integer of from zero to six; R 1 is an N-terminal blocking group selected from and R 2 and R 3 are independently hydrogen, straight or branched alkyl of from one to six carbon atoms, trifluoromethyl, -CH 2 -CH=CH 2 , -CH 2 -C≡CH, -CH 2 0R, -(CH 2 ) m COOR, -(CH 2 ) m NR 6 R 7 , -CH 2 Ar or -CH 2 OAr, where m is an integer of from one to six, R, R 6 , and R 7 are selected from hydrogen, or straight or branched alkyl of from one to six carbon atoms, and Ar is 2-, or 3-thienyl, 2-, 3-, or 4-pyridinyl, or where X and Y are independently hydrogen, fluorine, chlorine, methyl, methoxyl, trifluoromethyl, or nitro, with the provisos that when X is nitro, Y is hydrogen, and R 2 and R 3 may not both be hydrogen, R 4 is hydrogen, -CH 2 OH, -CONR 6 R 7 , -CH 2 NR 6 R 7 , -COOR or where Z is -CH 2 -, >NR, oxygen, or sulfur, and R, R 6 , and R 7 are as previously defined, and R 5 is 2- or 3-thienyl, 2-, 3-, or 4-pyridinyl, 2- or 3-indanyl, cyclohexyl, 2- or 3-furanyl, 3- or 4-pyridazinyl, 2-imidazolyl, 2-benzimidazolyl, 2-tetrahydrobenzimidazolyl, 2-perimidyl, or where X and Y are independently hydrogen, fluorine, chlorine, methyl, methoxyl, trifluoromethyl, or nitro, with the proviso that when X is nitro, Y is hydrogen, or a pharmaceutically acceptable salt thereof.