EP0221700A2
Expired / Lapsed
EP
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A thrombin preparation
Assignee: Warner Lambert Co LLC
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Filing: 1986-10-14
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Granted: —
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Expires: 2006-10-14
Abstract
Abstract A thrombin preparation which has enhanced stability is disclosed. In addition to the thrombin, the preparation comprises a buffer in an amount sufficient to stabilise the thrombin and to buffer the preparation at a pH in the range of from 5.0 to 8.0. The preparation may also include saline and a polyol/polyalkylene polyol. A method for making the preparation is also disclosed.
Inventors
- 👤 Steven B. Silbering
- 👤 Russell U. Nesbitt
- 👤 Mahdi B. Fawzi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 03:36
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/48; A61L; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0047; A61K38/482; A61K38/4833; A61P; A61P7/00; A61P7/04; Y; Y10; Y10S; Y10S128/00; Y10S128/22
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
42 words
A method for manufacturing a thrombin preparation having enhanced stability, which method comprises, combining thrombin with a quantity of a buffer sufficient to stabilise the thrombin and to buffer the preparation at a pH in the range of from 5.0 to 8.0.
Claim 2
Independent Claim
42 words
A method for manufacturing a thrombin preparation having enhanced stability, which method comprises, combining thrombin with a quantity of a buffer sufficient to stabilise the thrombin and to buffer the preparation at a pH in the range of from 5.0 to 8.0.
Claim 3
Dependent Claim
29 words
A method according to Claim 7, wherein the preparation is buffered at a pH in the range of from 5.0 to 6.0, preferably at a pH of about 5.3.
Claim 4
Dependent Claim
22 words
A method according to Claim 1 to 2, comprising further combining the thrombin buffer with saline and at least one polyhydroxy stabilizer.
Claim 5
Dependent Claim
31 words
A method according to Claim 3, wherein the stabilizer is chosen from C 3-12 polyols, polyethylene polyols having molecular weights in the range of from 200 to 8000 and mixtures thereof.
Claim 6
Independent Claim
14 words
A method according to any preceding Claim, wherein the buffer is an acetate buffer.
Claim 7
Dependent Claim
24 words
A hemeostat, for use as a wound dressing, comprising a preparation prepared by a method as claimed in any preceding claim and a substrate.
References Cited (Backward Citations)
No citation records indexed.
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