EP0216539A2
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EP
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Novel amino acid derivatives
Assignee: Kissei Pharmaceutical Co Ltd
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Filing: 1986-09-02
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Granted: —
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Expires: 2006-09-02
Abstract
Abstract Novel amino acid derivatives useful as a therapeutic agent are disclosed. These amino acid derivatives and the pharmaceutically acceptable salts thereof have a human renin inhibitory effect when administered orally and are useful for treatment of hypertension, especially renin-associated hypertension.
Inventors
- 👤 Kinji Iizuka
- 👤 Tetsuhide Kamijo
- 👤 Tetsuhiro Kubota
- 👤 Kenji Akahane
- 👤 Hideaki Umeyama
- 👤 Yoshiaki Kiso
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-08 13:11
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/16; C07D295/18; C07D295/182; C07D295/185; A; A61; A61P; A61P43/00; A61P9/00; A61P9/12; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
71 words
An amino acid derivative represented by the formula: wherein R 1 represents in which R 1 represents a lower alkyl group, X represents an amino residual group selected from glycine, alanine, β-alanine, valine, leucine, phenylalanine, tryptophane and serine, n is zero or 1, Y represents -O-, or -NH-, and R 2 represents a straight- or branched- chain alkyl group having 1 to 7 carbon atoms, and a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
71 words
An amino acid derivative represented by the formula: wherein R 1 represents in which R 1 represents a lower alkyl group, X represents an amino residual group selected from glycine, alanine, β-alanine, valine, leucine, phenylalanine, tryptophane and serine, n is zero or 1, Y represents -O-, or -NH-, and R 2 represents a straight- or branched- chain alkyl group having 1 to 7 carbon atoms, and a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
42 words
An amino acid derivative as claimed in claim 1 represented by formula: C represents a carbon atom in the S-configuration, R 1 , X, n, Y and R 2 have the same meanings as defined above, and a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
33 words
An amino acid derivative as claimed in claim 2 represented by formula: wherein X, C, n, Y and R 2 have the same meanings as defined above, and a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
33 words
The amino acid derivative as claimed in claim 3 represented by formula: * wherein Ala represents an L-alanyl group, C has the same meaning as defined above, and a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
33 words
The amino acid derivative as claimed in claim 3 represented by formula: wherein Leu represents an L-leucyl group, and C has the same meaning as defined above, and a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
30 words
The amino acid derivative as claimed in claim 3 represented by formula: * wherein Leu and C have the same meanings as defined above, and a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
29 words
The amino acid derivative as claimed in claim 3 represented by formula: wherein Leu and C have the same meanings as defined above, and a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
34 words
The amino acid derivative as claimed in claim 3 represented by formula: * wherein Val represents a valyl group, and C has the same meaning as defined above, and a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
33 words
The amino acid derivative as claimed in claim 3 represented by formula: * wherein Phe represents an L-phenylalanyl group, C has the same meaning as defined above, and a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
32 words
The amino acid derivative as claimed in claim 3 represented by formula: wherein Trp represents an L-tryptophyl group, C has the same meaning as defined above, and a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
34 words
ll. The amino acid derivative as claimed in claim 3 represented by formula: * wherein Ser represents an L-seryl group, C has the same meaning as defined above, and a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim
33 words
The amino acid derivative as claimed in claim 3 represented by formula: * wherein Gly represents a glycyl group, C has the same meaning as defined above, and a pharmaceutically acceptable salt thereof.
Claim 14
Dependent Claim
32 words
The amino acid derivative as claimed in claim 3 represented by formula: wherein β-Ala represents an β-alanyl group, C has the same meaning as defined above, and a pharmaceutically acceptable salt thereof.
Claim 15
Dependent Claim
29 words
The amino acid derivative as claimed in claim 2 represented by formula: wherein Ala and C have the same meanings as defined above, and a pharmaceutically acceptable salt thereof.
Claim 16
Dependent Claim
29 words
The amino acid derivative as claimed in claim 2 represented by formula: wherein Ala and C have the same meanings as defined above, and a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
No citation records indexed.
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