EP0215654A2
Expired / Lapsed
EP
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Macrolide antibiotics and their preparation
Assignee: Wyeth Holdings LLC
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Filing: 1986-09-12
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Granted: —
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Expires: 2006-09-12
Abstract
Abstract Compounds are described of formula (1) and salts thereof, wherein OR is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms, R 1 represents a methyl, ethyl or isopropyl group and the broken line represents a double bond at the 22,23-position or at the 23,24-position. These compounds may be used for controlling insect, acarine, nematode or other pests.
Inventors
- 👤 John B. Ward
- 👤 Hazel M. Noble
- 👤 Neil Porter
- 👤 Richard A. Fletton
- 👤 David Noble
- 👤 Derek R. Sutherland
- 👤 Michael V. J. Ramsay
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-03 11:30
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/01; A; A61; A61P; A61P31/00; A61P31/10; A61P33/00; A61P33/10
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
48 words
Compounds of formula (I) and salts thereof, wherein OR is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms, R 1 represents a methyl, ethyl or isopropyl group and the broken line represents a double bond at the 22,23-position or at the 23,24-position.
Claim 2
Dependent Claim
48 words
Compounds of formula (I) and salts thereof, wherein OR is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms, R 1 represents a methyl, ethyl or isopropyl group and the broken line represents a double bond at the 22,23-position or at the 23,24-position.
Claim 3
Dependent Claim
183 words
Compounds according to claim 1 in which OR is a group -OCOR 2 , -OCO 2 R 2 or -OCSOR 2 (where R 2 is C 1-8 alkyl; C l-8 alkyl substituted by one or more halo, carboxy, C 1-4 alkoxy, phenoxy or silyloxy substituents; C 2-8 alkenyl; C 2-8 alkynyl; C 3-12 cycloalkyl; aralkyl in which the alkyl portion has 1-6 carbon atoms and the aryl group contains 4-15 carbon atoms; or C 4-15 aryl), a form y lox y group, a group -OR 3 (where R is as defined above for R 2 ), a group -OSO 2 R 4 (where R 4 is a C 1-4 alkyl or C 6-10 aryl group), a silyloxy group, a (C 5-7 ) cyclic or acyclic acetaloxy group, a group -OCO(CH 2 ) n CO 2 R 5 (where R 5 is a hydrogen atom or a group as defined for R 2 above and n represents zero, 1 or 2) or a group OCONR 6 R 7 (where R 6 and R independently represent a hydrogen atom or a C 1-4 alkyl group).
Claim 4
Dependent Claim
15 words
Compounds according to claim 1 in which OR is a methoxycarbonyloxy, acetoxy or hydroxyl group.
Claim 5
Dependent Claim
12 words
Compounds according to claim 1 in which OR is a hydroxyl group.
Claim 6
Dependent Claim
13 words
Compounds according to any preceding claim in which R is an isopropyl group.
Claim 7
Dependent Claim
13 words
Compounds according to any preceding claim having a double bond at the 22,23-position.
Claim 8
Dependent Claim
28 words
The compound according to claim 1 in which R 1 is an isopropyl group, OR is a hydroxyl group and a double bond is present at the 22,23-position.
Claim 9
Dependent Claim
31 words
A composition for use in human or veterinary medicine containing an effective amount of at least one compound according to any preceding claim together with one or more carriers and/or excipients.
Claim 10
Dependent Claim
29 words
A pest control composition containing an effective amount of at least one compound according to any of claims 1 to 7 together with one or more carriers and/or excipients.
Claim 11
Dependent Claim
122 words
A process for the preparation of a compound according to claim 1 which comprises: (a) elimination of HL from a compound of formula (II) (where L is an eliminatable group), followed if desired by removal of a group R (where R is other than -H) to form a compound in which R is -H and optionally subsequently introducing a desired group R into said compound in which R is -H; (b) in the preparation of a compound in which OR is a substituted hydroxyl group, modifying a compound of formula (I) in which R is -H to introduce the desired R group; or (c) in the preparation of a salt of an acid of formula (I), treating said acid with a base.
References Cited (Backward Citations)
No citation records indexed.
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