EP0215419A2
Expired / Lapsed
EP
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Volume metering capillary gap device for applying a liquid sample onto a reactive surface
Assignee: Bayer Corp
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Filing: 1986-09-08
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Granted: —
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Expires: 2006-09-08
Abstract
Abstract A method for volume metering of a liquid sample onto a reactive surface and a flow metering capillary device for controlled fluid flow comprising two opposing surface areas spaced apart throughout a capillary zone of intended liquid transport at a distance no greater than that which will maintain a capillary flow of liquid introduced therebetween, means to permit Introduction of a test specimen between these surfaces, there being formed between said opposing surfaces an overflow channel and an overflow chamber which draws any excess liquid from the means for introducing the liquid between the surfaces.
Inventors
- 👤 Joel M. Blatt
- 👤 Robert Heiland
- 👤 James R. Morris
- 👤 Jerry T. Pugh
- 👤 Frank W. Wogoman
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 17:39
CPC Classifications
B; B01; B01L; B01L3/00; B01L3/50; B01L3/502; B01L3/5027; B01L3/502738; B01L2200/00; B01L2200/06; B01L2200/0605; B01L2300/00; B01L2300/08; B01L2300/0809; B01L2300/0825; B01L2300/0887; B01L2400/00; B01L2400/04; B01L2400/0403; B01L2400/0406; B01L3/5023; B01L3/502746; B29; B29C; B29C65/00; B29C65/02; B29C65/08; B29C66/00; B29C66/01; B29C66/05; B29C66/10; B29C66/11; B29C66/112; B29C66/1122; B29C66/302; B29C66/3022; B29C66/50; B29C66/51; B29C66/54; B29C66/543; B29L; B29L2031/00; B29L2031/756
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
133 words
A flow metering capillary device for controlled fluid flow comprising two oppositely disposed surfaces defining therebetween a capillary zone of intended liquid transport, said surfaces being spaced apart at a distance no greater than which will maintain a capillary flow of liquid therebetween, one of said surface layers constituting a top layer provided, the other of said surfaces retaining interactive material capable of reacting with a component of a test liquid to provide a detectable response, means to permit introduction of said test liquid between said surfaces, and said oppositely disposed surfaces having formed therebetween a sample test chamber and an overflow chamber wherein said chambers are connected by a channel adapted to convey excess test liquid from the means to permit introduction of test liquid between the surfaces to said overflow chamber.
Claim 2
Dependent Claim
133 words
A flow metering capillary device for controlled fluid flow comprising two oppositely disposed surfaces defining therebetween a capillary zone of intended liquid transport, said surfaces being spaced apart at a distance no greater than which will maintain a capillary flow of liquid therebetween, one of said surface layers constituting a top layer provided, the other of said surfaces retaining interactive material capable of reacting with a component of a test liquid to provide a detectable response, means to permit introduction of said test liquid between said surfaces, and said oppositely disposed surfaces having formed therebetween a sample test chamber and an overflow chamber wherein said chambers are connected by a channel adapted to convey excess test liquid from the means to permit introduction of test liquid between the surfaces to said overflow chamber.
Claim 3
Dependent Claim
17 words
The device of claim 1 which includes means for removing excess test liquid from said overflow chamber.
Claim 4
Dependent Claim
21 words
3 . The device of any of claims 1 and 2 wherein the interactive material is a reagent impregnated responsive layer.
Claim 5
Independent Claim
17 words
The device of any of claims 1 to 3, which additionally has present an absorbent wicking layer.
Claim 6
Independent Claim
28 words
The device of any of claims 1 to 4, wherein said top layer has a relief port for venting air, an overflow port and a sample introduction port.
Claim 7
Dependent Claim
175 words
A flow metering capillary device for controlled fluid flow comprising a top surface layer, a bottom reagent interactive layer and a spacer layer positioned therebetween and defining a capillary zone of intended liquid transport of a dimension no greater than that which will maintain a capillary flow of liquid introduced into said zone, said device having an air relief vent opening and an opening means to permit introduction of a liquid test specimen into said zone, said bottom reagent interactive layer including a film base and a reagent or reagent forming component that will interact with a predetermined analyte, said spacer layer having formed therein an overflow proportioning channel, an overflow chamber and test chamber, means for removing excess of the liquid test specimen, there being a channel in said spacer layer connecting the test chamber and the overflow chamber such that when the liquid flows into the overflow chamber, the channel will be free of liquid and will draw any excess liquid from the means for introducing the liquid test specimen into said zone.
Claim 8
Dependent Claim
175 words
A flow metering capillary device for controlled fluid flow comprising a top surface layer, a bottom reagent interactive layer and a spacer layer positioned therebetween and defining a capillary zone of intended liquid transport of a dimension no greater than that which will maintain a capillary flow of liquid introduced into said zone, said device having an air relief vent opening and an opening means to permit introduction of a liquid test specimen into said zone, said bottom reagent interactive layer including a film base and a reagent or reagent forming component that will interact with a predetermined analyte, said spacer layer having formed therein an overflow proportioning channel, an overflow chamber and test chamber, means for removing excess of the liquid test specimen, there being a channel in said spacer layer connecting the test chamber and the overflow chamber such that when the liquid flows into the overflow chamber, the channel will be free of liquid and will draw any excess liquid from the means for introducing the liquid test specimen into said zone.
Claim 9
Dependent Claim
25 words
The device of claim 6, wherein the test chamber is connected to a capillary lock channel which is connected to said air relief vent opening.
Claim 10
Independent Claim
17 words
The device of any of claims 6 end 7, which additionally has present an absorbent wicking layer.
Claim 11
Dependent Claim
24 words
The device of claim 7, wherein said capillary lock is arranged so as to terminate directly underneath the air port in the top layer.
Claim 12
Independent Claim
153 words
A method for the distribution of a liquid sample in a fluid flow onto a test surface located in a capillary test device comprising applying a fluid sample to a capillary test device comprising two opposing surface areas defining a capillary zone of intended liquid transport and being spaced apart at a distance no greater than that which will maintain a capillary flow of liquid introduced therebetween, means to permit introduction of a test specimen between said surfaces, there being formed between said opposing surfaces an overflow channel and an overflow chamber and test chamber, one of said two surfaces having a relief opening for air, there being a channel connecting the reagent chamber and the overflow chamber such that when the fluid sample flows into the overflow chamber, the overflow channel will be free of liquid and will draw any excess liquid from the means for introducing the liquid between the surfaces.
Claim 13
Independent Claim
153 words
A method for the distribution of a liquid sample in a fluid flow onto a test surface located in a capillary test device comprising applying a fluid sample to a capillary test device comprising two opposing surface areas defining a capillary zone of intended liquid transport and being spaced apart at a distance no greater than that which will maintain a capillary flow of liquid introduced therebetween, means to permit introduction of a test specimen between said surfaces, there being formed between said opposing surfaces an overflow channel and an overflow chamber and test chamber, one of said two surfaces having a relief opening for air, there being a channel connecting the reagent chamber and the overflow chamber such that when the fluid sample flows into the overflow chamber, the overflow channel will be free of liquid and will draw any excess liquid from the means for introducing the liquid between the surfaces.
References Cited (Backward Citations)
No citation records indexed.
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