EP0212641A2
Expired / Lapsed
EP
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Taste masking compositions
Assignee: Procter and Gamble Co
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Filing: 1986-08-22
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Granted: —
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Expires: 2006-08-22
Abstract
Abstract This invention relates to drug-polymer matrix compositions comprising an active ingredient having an amine or amido group and a pharmaceutically acceptable copolymer having a plurality of carboxylic acid and ester groups wherein the matrix dissociates in a media having a pH of less than 4, thereby releasing the active ingredient into the media.
Inventors
- 👤 Nalinkant Chunilal Damani
- 👤 Josef Hengko Tsau
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 18:19
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1652; A61K9/0012; A61K9/0053; A61K9/0056; A61K9/1635
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
48 words
A drug-polymer matrix comprising an active ingredient having an amine or amido group and a pharmaceutically acceptable copolymer having a plurality of carboxylic acid and ester groups wherein the matrix dissociates in a media having a pH less than 4, thereby releasing the active ingredient into the media.
Claim 2
Dependent Claim
48 words
A drug-polymer matrix comprising an active ingredient having an amine or amido group and a pharmaceutically acceptable copolymer having a plurality of carboxylic acid and ester groups wherein the matrix dissociates in a media having a pH less than 4, thereby releasing the active ingredient into the media.
Claim 3
Dependent Claim
17 words
A drug-polymer matrix according to Claim 1 wherein the active ingredient is diphenhydramine or a salt thereof.
Claim 4
Dependent Claim
22 words
A drug-polymer matrix according to Claim 2 wherein the pharmaceutically acceptable copolymer is a copolymer of methacrylic acid and its methyl ester.
Claim 5
Dependent Claim
17 words
A drug-polymer matrix according to Claim 1 wherein the active ingredient is dextromethorphan or a salt thereof.
Claim 6
Dependent Claim
18 words
A drug-polymer matrix according to Claim 4 wherein the pharmaceutically acceptable copolymer is a copolymer of polyvinylacetate phthalate.
Claim 7
Dependent Claim
24 words
A drug-polymer matrix according to Claim 1 wherein the active ingredient is pseudoephedrine, dextromethorphan or chlorpheniramine or a salt thereof or a mixture thereof.
Claim 8
Dependent Claim
15 words
A drug-polymer matrix according to Claim 6 wherein the pharmaceutically acceptable copolymer is Eudragit S-100.
Claim 9
Independent Claim
70 words
A method for producing a drug-polymer matrix capable of masking the taste of an active ingredient having an amine or amido group and releasing the active ingredient into a media having a pH of less than 4, comprising mixing the active ingredient with a pharmaceutically acceptable copolymer having a plurality of carboxylic acid and ester groups in the presence of a solvent and removing the solvent to yield the matrix.
Claim 10
Independent Claim
70 words
A method for producing a drug-polymer matrix capable of masking the taste of an active ingredient having an amine or amido group and releasing the active ingredient into a media having a pH of less than 4, comprising mixing the active ingredient with a pharmaceutically acceptable copolymer having a plurality of carboxylic acid and ester groups in the presence of a solvent and removing the solvent to yield the matrix.
Claim 11
Dependent Claim
18 words
A method according to Claim 8 wherein the solvent is removed under reduced vacuum and at elevated temperatures.
Claim 12
Dependent Claim
15 words
A method according to Claim 9 wherein the solvent is a ketone or an alcohol.
Claim 13
Dependent Claim
26 words
A method according to Claim 10 wherein the active ingredient is selected from the class consisting of diphenhydramine or a salt thereof, pseuodoephedrine, dextromethorphan or chlorpheniramine.
Claim 14
Dependent Claim
34 words
A method according to Claim 10 wherein the copolymer is selected from the group consisting of a copolymer of acrylic and substituted acrylic acids and esters thereof, vinyl and substituted vinyl acids and esters.
References Cited (Backward Citations)
No citation records indexed.
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