EP0200539A2
Expired / Lapsed
EP
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Method of preparing coating compositions containing antisera and elements containing same
Assignee: Eastman Kodak Co
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Filing: 1986-04-30
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Granted: —
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Expires: 2006-04-30
Abstract
Abstract A method for preparing a blush polymer coating composition containing active antisera comprises milling dehydrated antisera and the other materials used in the composition to uniformly disperse the antisera therein. This coating composition can be used to prepare analytical elements for determining analytes (e.g. creatine kinase-MB) whereby the effects of potential interferents are immunochemically removed. By milling the antisera into the coating composition, the resulting element has improved stability resulting in improved keeping in high humidity environments.
Inventors
- 👤 John Bruce Findlay
- 👤 Annie Liu Wu
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-30 21:32
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/544; G01N33/545; G01N33/573; Y; Y10; Y10S; Y10S435/00; Y10S435/808; Y10S436/00; Y10S436/807; Y10S436/81
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
61 words
A method for preparing a blush polymer coating composition containing active antisera and particulate material in a polymeric binder material, the method characterized by milling dehydrated antisera, the particulate material and the polymeric binder material in an organic solvent for a time sufficient to uniformly disperse the antisera as particles less than about 5 µm in diameter in the binder material.
Claim 2
Independent Claim
61 words
A method for preparing a blush polymer coating composition containing active antisera and particulate material in a polymeric binder material, the method characterized by milling dehydrated antisera, the particulate material and the polymeric binder material in an organic solvent for a time sufficient to uniformly disperse the antisera as particles less than about 5 µm in diameter in the binder material.
Claim 3
Dependent Claim
21 words
The method as claimed in claim 1 wherein the milling is carried out by sand milling, pebble milling or ball milling.
Claim 4
Independent Claim
67 words
A method for preparing an analytical element comprising a porous blush polymer spreading layer containing active antisera, the method characterized by applying to a support a coating composition prepared by milling dehydrated antisera, a particulate material and a polymeric binder material in an organic solvent for a time sufficient to uniformly disperse the antisera as particles less than about 5 µm in diameter in the binder material.
Claim 5
Independent Claim
67 words
A method for preparing an analytical element comprising a porous blush polymer spreading layer containing active antisera, the method characterized by applying to a support a coating composition prepared by milling dehydrated antisera, a particulate material and a polymeric binder material in an organic solvent for a time sufficient to uniformly disperse the antisera as particles less than about 5 µm in diameter in the binder material.
Claim 6
Dependent Claim
24 words
The method as claimed in claim 3 wherein an intermediate layer is applied to the support prior to application of the blush polymer composition.
Claim 7
Independent Claim
25 words
The method as claimed in either of claims 3 or 4 wherein the blush polymer composition is applied as the outermost layer of the element.
Claim 8
Dependent Claim
53 words
An analytical element for the determination of an analyte comprising a support having thereon a porous blush polymer spreading layer containing active antisera uniformly dispersed therein, the element characterized by exhibiting at least 75% retained sensitivity for the analyte after being kept at 25°C and 50K relative humidity for at least 6 days.
Claim 9
Dependent Claim
53 words
An analytical element for the determination of an analyte comprising a support having thereon a porous blush polymer spreading layer containing active antisera uniformly dispersed therein, the element characterized by exhibiting at least 75% retained sensitivity for the analyte after being kept at 25°C and 50K relative humidity for at least 6 days.
Claim 10
Dependent Claim
19 words
The invention as claimed in any of claims 1 to 6 wherein the particulate material is an inorganic pigment.
Claim 11
Dependent Claim
13 words
The invention as claimed in claim 6 wherein the pigment is titanium dioxide.
Claim 12
Dependent Claim
19 words
The invention as claimed in any of claims 1 to 8 wherein the antisera comprises antibodies for creatine kinase-MM.
Claim 13
Dependent Claim
18 words
The invention as claimed in any of claims 1 to 9 wherein the binder material is cellulose acetate.
References Cited (Backward Citations)
No citation records indexed.
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