EP0200467A2
Expired / Lapsed
EP
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Superoxide dismutase combined with a poly(alkylene oxide)
Assignee: Ajinomoto Co Inc
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Filing: 1986-04-23
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Granted: —
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Expires: 2006-04-23
Abstract
Abstract Superoxide dismutase is chemically modified with poly(alkylene oxide), the modified superoxide dismutase having a molecular structure in which both ends of a poly(alkylene oxide) molecule are attached to superoxide dismutase. The modified superoxide dismutase can be used to remove toxic substances derived from oxygen, from the blood circulation in a living body, and has a longer half life in the blood circulation as compared to superoxide dismutase which has not been modified.
Inventors
- 👤 Akira Yabuki
- 👤 Yuji Iwashita
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 14:41
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/96; A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/44; A61K38/446; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; C12N9/0004; C12N9/0089
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
33 words
A superoxide dismutase chemically modified with poly(alkylene oxide), characterised in that said modified superoxide dismutase has a molecular structure in which both ends of a poly(alkylene oxide) molecule are attached to superoxide dismutase.
Claim 2
Dependent Claim
33 words
A superoxide dismutase chemically modified with poly(alkylene oxide), characterised in that said modified superoxide dismutase has a molecular structure in which both ends of a poly(alkylene oxide) molecule are attached to superoxide dismutase.
Claim 3
Dependent Claim
28 words
A modified superoxide dismutase as claimed in Claim 1, wherein said poly(alkylene oxide) is selected from poly(ethylene oxide), poly(propylene oxide), and copolymers of ethylene oxide and propylene oxide.
Claim 4
Dependent Claim
24 words
A modified superoxide dismutase as claimed in Claim 1 or 2, wherein each of said ends of said poly(alkylene oxide) comprises a carboxyl group.
Claim 5
Dependent Claim
37 words
A modified superoxide dismutase as claimed in Claim 3, wherein each of said ends of said poly(alkylene oxide) have the structure: -CH 2 ―O―(CH 2 ) m ―COOH wherein m is an integer of 1 to 12.
Claim 6
Dependent Claim
40 words
A modified superoxide dismutase as claimed in Claim 3, wherein each of said ends of said poly(alkylene oxide) have the structure: -CH 2 -N-C―(CH 2 ) m ―COOH wherein m is an integer of 1 to 1 2. H 0
Claim 7
Dependent Claim
34 words
A modified superoxide dismutase as claimed in any of Claims 1 to 5, wherein the average number of said poly(alkylene oxide) molecules attached to one molecule of superoxide dismutase is from 0.5 to 10.
Claim 8
Dependent Claim
26 words
A modified superoxide dismutase as claimed in any of Claims 1 to 6, wherein said poly(alkylene oxide) has a molecular weight of from 400 to 20,000.
Claim 9
Dependent Claim
22 words
A modified superoxide dismutase as claimed in any of Claims 1 to 7, having a molecular weight of from 70,000 to 500,000.
Claim 10
Dependent Claim
47 words
A modification of a modified superoxide dismutase as claimed in any of Claims 1 to 8, wherein only one end of said poly(alkylene oxide) is attached to superoxide dismutase, and wherein the another end of said poly(alkylene oxide) comprises a carboxyl group protected by an amino acid.
Claim 11
Dependent Claim
17 words
A modified superoxide dismutase as claimed in Claim 9, wherein said amino acid is glycine or lysine.
Claim 12
Dependent Claim
41 words
A process for production of a stabilized superoxide dismutase modified chemically with poly(alkylene oxide), which comprises reacting poly(alkylene oxide) having carboxyl groups at both ends thereof with superoxide dismutase to form said modified superoxide dismutase via the formation of amide bonds.
Claim 13
Dependent Claim
41 words
A process for production of a stabilized superoxide dismutase modified chemically with poly(alkylene oxide), which comprises reacting poly(alkylene oxide) having carboxyl groups at both ends thereof with superoxide dismutase to form said modified superoxide dismutase via the formation of amide bonds.
Claim 14
Dependent Claim
22 words
A pharmaceutical composition comprising modified superoxide dismutase as claimed in any of claims 1 to 10, and a pharmaceutically-acceptable carrier or diluent.
References Cited (Backward Citations)
No citation records indexed.
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