Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
71 words
A method of a virus-inactivating heat treatment of an aqueous γ-globulin solution, comprising adding to the aqueous solution an amount sufficient for stabilizing y-globulin therein of at least one stabilizer selected from the group consisting of a monosaccharide, a disaccharide and a sugaralcohol, and heating the aqueous solution at a temperature of 50° to 70°C for a period sufficient substantially to free the aqueous α-globulin solution from infectivity of a virus.
Claim 2
Independent Claim
71 words
A method of a virus-inactivating heat treatment of an aqueous γ-globulin solution, comprising adding to the aqueous solution an amount sufficient for stabilizing y-globulin therein of at least one stabilizer selected from the group consisting of a monosaccharide, a disaccharide and a sugaralcohol, and heating the aqueous solution at a temperature of 50° to 70°C for a period sufficient substantially to free the aqueous α-globulin solution from infectivity of a virus.
Claim 3
Dependent Claim
20 words
The method of Claim 1, wherein the aqueous solution contains 0.1 to 30% (w/v) of γ-globulin in terms of protein.
Claim 4
Dependent Claim
16 words
The method of Claim 1, wherein the aqueous solution has a pH of 4.5 to 10.
Claim 5
Dependent Claim
24 words
The method of Claim 1 or 2, wherein the amount of the stabilizer is 10 to 100 g per 100 ml of the solution.
Claim 6
Dependent Claim
22 words
The method of Claim 4, wherein the amount of the stabilizer is 40 to 100 g per 100 ml of the solution.
Claim 7
Dependent Claim
72 words
6 . The method of any preceding Claim, wherein in addition to the stabilizer, an amount effective for decreasing anticomplement activity as compared with the use of the stabilizer alone, of at least one auxiliary stabilizer selected from the group consisting of a neutral amino acid, a neutral inorganic acid salt, an organic carboxylic acid having 3 to 10 carbon atoms and a surface active agent is added to the aqueous solution.
Claim 8
Dependent Claim
21 words
The method of Claim 6, wherein the amount of the neutral amino acid is 1-20 g per 100 ml of the.solution.
Claim 9
Dependent Claim
21 words
The method of Claim 6, wherein the amount of organic carboxylic acid is 1-30 g per 100 ml of the solution.
Claim 10
Dependent Claim
24 words
The method of Claim 6, wherein the amount of the inorganic acid salt is 0.1 to 10 g per 100 ml of the solution.
Claim 11
Dependent Claim
24 words
The method of Claim 6, wherein the amount of the surface active agent is 0.002 to 0.05 g per 100 ml of the solution.