EP0195906A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties
Assignee: Research Foundation of the State University of New York
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Filing: 1986-02-06
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Granted: —
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Expires: 2006-02-06
Abstract
Abstract @ Tetracyclines having substantially no effective antibiotic or antibacterial activity and possessing anti-collagen-destructive enzyme activity or anti-collagenase activity and compositions containing the same have been found useful as anti-collagenolytic agents. Such tetracyclines and compositions containing the same are useful in the treatment of periodontal diseases, corneal ulcers, bone deficiency disorders, rheumatoid arthritis diseases characterized by excessive collagen destruction. A special aspect of this invention involves the incorporation of such tetracyclines in animal feed compositions for improved animal nutrition, such as may be evidenced by increased weight gain.
Inventors
- 👤 Thomas F. Mcnamara
- 👤 Nungavaram S. Ramamurthy
- 👤 Lorne M. Golub
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 12:50
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/65; A61P; A61P1/00; A61P1/02; A61P3/00; A61P43/00
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
25 words
A composition comprising a tetracycline having substantially no effective antibiotic or antibacterial activity and possessing anti-collaaen-destructive enzyme activity or anti-collagenase activity and a carrier therefor.
Claim 2
Dependent Claim
25 words
A composition comprising a tetracycline having substantially no effective antibiotic or antibacterial activity and possessing anti-collaaen-destructive enzyme activity or anti-collagenase activity and a carrier therefor.
Claim 3
Dependent Claim
26 words
A composition according to claim 1 for use in the treatment of humans or animals suffering from a condition or disease characterized by excessive collagen destruction.
Claim 4
Dependent Claim
12 words
A composition in accordance with claim 1 wherein said tetracycline is dedimethylaminotetracycline.
Claim 5
Dependent Claim
17 words
A- composition in accordance with claim 1 for use in the treatment of ulceration of the cornea.
Claim 6
Dependent Claim
15 words
A composition in accordance with claim 1 for use in the treatment of periodontal disease.
Claim 7
Dependent Claim
15 words
A composition in accordance with claim 1 for use in the treatment of rheumatoid arthritis.
Claim 8
Dependent Claim
25 words
A composition in accordance with claim 1 for use in the treatment of periodontal disease, skin lesions and/or other diseases said tetracycline being topically applied.
Claim 9
Dependent Claim
18 words
A composition in accordance with claim 7 said tetracycline being releasably incorporated in a polymeric carrier or matrix.
Claim 10
Dependent Claim
12 words
A composition in accordance with claim 1 said tetracycline being administered systemically.
Claim 11
Dependent Claim
12 words
A composition in accordance with claim 1 said tetracycline being administered orally.
Claim 12
Dependent Claim
14 words
A composition in accordance with claim 1 wherein said carrier is an aqueous carrier.
Claim 13
Dependent Claim
21 words
A composition in accordance with claim 1 wherein said composition is in the form of a tablet, granule, lozenge or capsule.
Claim 14
Dependent Claim
16 words
A composition in accordance with claim 1 wherein said carrier is a solid physiologically acceptable matrix.
Claim 15
Dependent Claim
40 words
An animal feed composition comprising a tetracycline having substantially no effective antibiotic or antibacterial activity and possessing anti-collagenase activity or anti-collagen-destructive enzyme activity and animal feed, said tetracycline being present in said animal feed composition in an effective anti-collagenase amount.
Claim 16
Dependent Claim
40 words
An animal feed composition comprising a tetracycline having substantially no effective antibiotic or antibacterial activity and possessing anti-collagenase activity or anti-collagen-destructive enzyme activity and animal feed, said tetracycline being present in said animal feed composition in an effective anti-collagenase amount.
Claim 17
Dependent Claim
14 words
An animal feed composition in accordance with claim 14 wherein said tetracycline is dedimethylaminotetracycline.
References Cited (Backward Citations)
No citation records indexed.
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