EP0195577A2
Expired / Lapsed
EP
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Coated transplants and method for making same
Assignee: University of California Berkeley
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Filing: 1986-03-11
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Granted: —
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Expires: 2006-03-11
Abstract
Abstract Transplants, such as pancreatic islets, are made suitable for transplantation into a genetically dissimilar individual by coating the transplant with a surface-conforming bonding bridge layer of a multifunctional material that binds chemically to a surface component of the transplant followed by a semipermeable, biologically compatible layer of a polymer that binds chemically to the bonding bridge layer.
Inventors
- 👤 Kent C. Cochrum
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 18:44
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5073; A61F; A61F2/00; A61F2/02; A61F2/022; A61K9/14; A61K9/16; A61K9/1605; A61K9/1611; A61K9/5005; A61K9/5021; A61K9/5031; A61L; A61L27/00; A61L27/28; A61L27/34; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/29
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
81 words
A coated transplant suitable for transplantation into a genetically dissimilar individual characterized in that the transplant is coated with an immunological barrier membrane that conforms to the surface of the transplant, said membrane comprising a noncytotoxic inner layer that is bonded chemically to the surface of the transplant, optionally one or more intermediate. layers of innocuous material, and an outer biologically compatible, water-insoluble semipermeable layer bonded chemically to the inner layer or the contiguous intermediate layer, as the case may be.
Claim 2
Dependent Claim
81 words
A coated transplant suitable for transplantation into a genetically dissimilar individual characterized in that the transplant is coated with an immunological barrier membrane that conforms to the surface of the transplant, said membrane comprising a noncytotoxic inner layer that is bonded chemically to the surface of the transplant, optionally one or more intermediate. layers of innocuous material, and an outer biologically compatible, water-insoluble semipermeable layer bonded chemically to the inner layer or the contiguous intermediate layer, as the case may be.
Claim 3
Dependent Claim
56 words
The coated transplant of claim 1 further characterized in that the inner layer is comprised of: (a) aluminum hydroxide; (b) a disaccharide; (c) a polyfunctional cross-linking agent; (d) an immunoglobulin to a surface component of the transplant: (e) a lectin: or (f) a polyionic polyamino acid having an opposite charge to that of the transplant surface.
Claim 4
Dependent Claim
36 words
The coated transplant of claim 1 further characterized in that the inner layer is comprised of aluminum hydroxide, a bifunctional disulfide, an immunoglobulin that binds to a MHC antigen of the transplant, concanavalin A. or polylysine.
Claim 5
Dependent Claim
31 words
The coated transplant of claim 1. 2, or 3 further characterized in that the outer layer is comprised of a polyamino acid that has reactive carboxyl, amino, or imino side groups.
Claim 6
Dependent Claim
25 words
The coated transplant of claim 5 further characterized in that the polyamino acid of the outer layer is polylysine, polyarginine, polyaspartic acid, or polyglutamic acid.
Claim 7
Independent Claim
115 words
A method of treating a transplant to make it suitable for transplantation into a genetically dissimilar individual characterized in that: (a) the transplant is first coated with a first layer of a noncytotoxic material that forms a chemical bond with the surface of the transplant, said first layer conforming to the surface of the transplant; (b) one or more intermediate layers of innocuous material is optionally coated over the first layer; and (c) the transplant is then coated with an outer layer of a polymeric material that forms a chemical bond with the material of the first layer or contiguous intermediate layer, as the case may be, said outer layer being biologically compatible and semipermeable.
Claim 8
Independent Claim
115 words
A method of treating a transplant to make it suitable for transplantation into a genetically dissimilar individual characterized in that: (a) the transplant is first coated with a first layer of a noncytotoxic material that forms a chemical bond with the surface of the transplant, said first layer conforming to the surface of the transplant; (b) one or more intermediate layers of innocuous material is optionally coated over the first layer; and (c) the transplant is then coated with an outer layer of a polymeric material that forms a chemical bond with the material of the first layer or contiguous intermediate layer, as the case may be, said outer layer being biologically compatible and semipermeable.
Claim 9
Dependent Claim
55 words
The method of claim 6 further characterized in that the inner layer is comprised of: (a) aluminum hydroxide: (b) a disaccharide: (c) a polyfunctional cross-linking agent; (d) an immunoglobulin to a surface component of the transplant: (e) a lectin: or (f) a polyionic polyamino acid having an opposite charge to that of the transplant surface.
Claim 10
Dependent Claim
35 words
The method of claim 6 further characterized in that the inner layer is comprised of aluminum hydroxide, a bifunctional disulfide, an immunoglobulin that binds to a MHC antigen of the transplant. concanavalin A, or polylysine.
Claim 11
Dependent Claim
30 words
The method of claim 6, 7, or 8 further characterized in that the outer layer is comprised of a polyamino acid that has reactive carboxyl, amino, or imino side groups.
Claim 12
Dependent Claim
24 words
The method of claim 9 further characterized in that the polyamino acid of the outer layer is poly-L-lysine, polyarginine, polyaspartic acid, or polyglutamic acid.
References Cited (Backward Citations)
No citation records indexed.
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