Controlled-release pharmaceutical formulation

Abstract

Abstract A pharmaceutical controlled release formulation is disclosed which does not substantially disintegrate but gradually releases a physiologically active substance in the gastrointestinal tract and which comprises a granulation product - (granules) obtained by adding release controlling agent (e.g. an aqueous suspension of a water insoluble macromolecular substance, an aqueous emulsion thereof, a water containing organic-solvent solution thereof, or water) to a mixture of i) physiologically active substance and ii) carrier substance (e.g. crystalline cellulose) in an amount of at least 5 0% by weight based on the weight of the product, and granulating the resultant mixture. The active substance containing granules have a high mechanical strength, disperse widely in the gastrointestinal tract when administered, are water permeable but do not substantially disintegrate in the gastrointestinal tract

Inventors

• 👤 Muneo Fukui
• 👤 Kouji Tomuro
• 👤 Shigeru Masuyama
• 👤 Atsushi 703-3 Kitamotodanchi Kajiyama
• 👤 Tamio Hikosaka
• 👤 Masayoshi Aruga
• 👤 Yoshiaki Soeishi
• 👤 Saburo Higuchi

Bibliographic Details