EP0194207A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Purified antigen from non-A, non-B Hepatitis causing factor
Assignee: United States Department of Commerce
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Filing: 1986-03-07
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Granted: —
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Expires: 2006-03-07
Abstract
Abstract 57 An isolated, purified non-A, non-B hepatitis (NANBH) associated antigen having the properties (a) molecular weight of monomer 77,000 daltons on sodium dodecyl sulphate polyacrylamide gel, (b) monomer reactive with rhesus monkey immune serum, (c) glycoprotein containing about 2% carbohydrate comprising (i) predominantly mannose and (ii) approximately equal molar amounts of fucose and galactose, (d) an aromatic amino acid composition comprising molar ratios of phenylalanine, tyrosine, and trypotophan of about 3:3: 1, respectively, and (e) immunogenicity is disclosed along with methods of preparing and using the antigen.
Inventors
- 👤 Belinda Pik-Lan Seto
- 👤 Robert John Gerety
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-31 11:57
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/12; A61K39/29; C; C12; C12N; C12N2770/00; C12N2770/00011; C12N2770/24011; C12N2770/24211; C12N2770/24234; Y; Y10; Y10S; Y10S435/00; Y10S435/81; Y10S435/961; Y10S436/00; Y10S436/82; Y10S530/00; Y10S530/82; Y10S530/826
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
81 words
An isolated, purified non-A, non-B hepatitis (NANBH) associated antigen having the following properties: (a) molecular weight of the monomer on sodium dodecyl sulphate polyacrylamide gel being about 77,000; (b) the monomer being reactive with rhesus monkey immune serum; (c) being a glycoprotein containing about 2% carbohydrate comprising predominantly mannose and about equal ratio of fucose and galactose; (d) having an aromatic amino acid composition comprising molecular ratios of phenylalanine, tyrosine and tryptophan of about 3:3:1 respectively; and (e) being an immunogen.
Claim 2
Dependent Claim
81 words
An isolated, purified non-A, non-B hepatitis (NANBH) associated antigen having the following properties: (a) molecular weight of the monomer on sodium dodecyl sulphate polyacrylamide gel being about 77,000; (b) the monomer being reactive with rhesus monkey immune serum; (c) being a glycoprotein containing about 2% carbohydrate comprising predominantly mannose and about equal ratio of fucose and galactose; (d) having an aromatic amino acid composition comprising molecular ratios of phenylalanine, tyrosine and tryptophan of about 3:3:1 respectively; and (e) being an immunogen.
Claim 3
Dependent Claim
24 words
The antigen of claim 1 being a specific marker for detecting the presence of non-A, non-B hepatitis factor in any carrier or source thereof.
Claim 4
Dependent Claim
20 words
The antigen of claim 2 being a specific serologic marker for screening blood in a blood bank or plasmapheresis setting.
Claim 5
Dependent Claim
18 words
The antigen of claim 1 capable of inducing in a suitable host antibodies specifically reactive to said antigen.
Claim 6
Dependent Claim
12 words
The antibodies of claim 4 capable of providing protection against NANBH infection.
Claim 7
Dependent Claim
15 words
6 . The antibodies of claim 4 suitable for differentiating said antigen from other antigens.
Claim 8
Dependent Claim
27 words
A kit for screening or detecting a carrier, source or causative factor of non-A, non-B hepatitis comprising a container containing an isolated, purified antigen of claim 1.
Claim 9
Dependent Claim
16 words
The kit of claim 7 further comprising a container containing antibodies specifically reactive to said antigen.
References Cited (Backward Citations)
No citation records indexed.
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