Dibenz (b,e) oxepin derivative and antiallergic agent

Abstract

Abstract A dibenz[b,e]oxepin derivative represented by the formula (I): {wherein A 1 is a hydrogen atom, a methyl group, (CH 2 ) m OR 1 [where m is an integer of 1 to 4, and R 1 is a hydrogen atom, CH 2 CH(OH)CH 2 OCH 2 CH 3 , CH 2 CH(OAc)CH 2 OCH 2 CH 3 or CH 2 OCH 2 CH 2 OCH 3 ], CH(CH 3 )CH 2 OR 1 (where R 1 has the same meaning as defined above), CH = CHC0 2 R 2 (where R 2 is a hydrogen atom or a lower alkyl group), (CH 2 ) n CO 2 R 2 (where n is an integer of 1 to 3, and R has the same meaning as defined above), CH(CH 3 )CO 2 R 2 (where R 2 has the same meaning as defined above), CO 2 (CH 2 )NR 3 R 4 (where is an integer of 1 to 6, and R 3 and R 4 are the same or different lower alkyl groups), CONHR 5 (where R 5 is a lower alkyl group). CO 2 CH 2 CH(OR 6 ),CH 2 OCH 2 CH 3 (where R 6 is a hydrogen atom or an acetyl group), C0 2 CH 2 CH 2 0CH 2 CH 2 0H or CO 2 X 1 (where X 1 is a hydrogen atom or a lower alkyl group). A 2 is a 4-lower alkylpiperazino group, a 4-lower alkylhomopiperazino group or Y-(CH 2 ) p NR 7 R 8 (where Y is NH, O or S, p is an integer of 2 to 5, and R 7 and R 8 are the same or different hydrogen atoms or lower alkyl groups). One of A3 and A4 is COR [where R 9 is a hydroxyl group, a lower alkoxy group, an 1-(ethoxycarbony- loxy)ethoxy group or an amino group] or a cyano group, and the other is a hydrogen atom; or A3 is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms and is a substituent at the 4-position, and A4 is a hydrogen atom.} has antiallergic activity such as antiasthmatic activity.

Inventors

• 👤 Toshiaki Kumazawa
• 👤 Etsuo Oshima
• 👤 Hiroyuki Obase
• 👤 Kanji Ohmori
• 👤 Hidee Ishii
• 👤 Katsuichi Shuto

Bibliographic Details