EP0179608A2
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EP
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Complexes of technetium-99m with propylene amine oximes
Assignee: GE Healthcare Ltd
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Filing: 1985-10-15
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Granted: —
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Expires: 2005-10-15
Abstract
Abstract Novel propylene amine oxime ligands have the formula where each of R,, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 or R 8 may be hydrogen, hydrocarbon, carboxyl, amine, amide or nitrile, provided that, if R, is the same as R 9 and R 2 is the same as R 7 , then R a is not H. These unsymmetrical ligands form complexes with Technetium-99m which are capable, on injection into mammals, of crossing the blood-brain barrier and of being retained in the brain for a time to permit diagnosis.
Inventors
- 👤 David Peter Nowotnik
- 👤 Lewis Reuben Canning
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-07 20:39
CPC Classifications
C; C07; C07F; C07F13/00; C07F13/005; A; A61; A61P; A61P43/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
138 words
A propylene amine oxime having the general formula wherein each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 is independently hydrogen, C 1 -C 8 straight- or branched-chain saturated or unsaturated alkyl, aralkyl, aryl, alkoxy, alkoxycarbonyl, alkylcarbonyl, alkylcarbonyloxy, primary secondary or tertiary amine or amide, or nitrile, or one or more of R 1 ,R 2 ; R 3 , R 4 ; R 5 , R 6 ; R 7 , R 8 ; R 8 , R 9 joined to form a fused or spiro carbocyclic or heterocyclic ring, provided that, when R 1 is are the same as R 9 and R 2 is the same as R 7 , then R 8 is not hydrogen.
Claim 2
Dependent Claim
138 words
A propylene amine oxime having the general formula wherein each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 is independently hydrogen, C 1 -C 8 straight- or branched-chain saturated or unsaturated alkyl, aralkyl, aryl, alkoxy, alkoxycarbonyl, alkylcarbonyl, alkylcarbonyloxy, primary secondary or tertiary amine or amide, or nitrile, or one or more of R 1 ,R 2 ; R 3 , R 4 ; R 5 , R 6 ; R 7 , R 8 ; R 8 , R 9 joined to form a fused or spiro carbocyclic or heterocyclic ring, provided that, when R 1 is are the same as R 9 and R 2 is the same as R 7 , then R 8 is not hydrogen.
Claim 3
Dependent Claim
47 words
A propylene amine oxime as claimed in Claim 1, wherein each of R 1 , R 2 , R 71 R 8 and R 9 is C1 to C4 alkyl, R 3 and R 6 are H, and R 4 and R 5 are H or methyl.
Claim 4
Dependent Claim
19 words
A lipophilic macrocyclic complex, useful as a diagnostic radiopharmaceutical, of Technetium-99m with the propylene amine oxime of Claim 1.
Claim 5
Dependent Claim
145 words
A complex of Technetium-99m with a propylene amine oxime, which complex has the formula wherein each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 is independently hydrogen, C 1 -C 8 straight- or branched-chain saturated or unsaturated alkyl, aralkyl, aryl, alkoxy, alkoxycarbonyl, alkylcarbonyl, alkylcarbonyloxy, primary secondary or tertiary amine or amide, or nitrile, or one or more of R 1 , R 2 ; R 3 , R 4 ; R 5 , R 6 ; R 7 , R 8 ; R 8 , R 9 are joined to form a fused or spiro carbocyclic or heterocyclic ring, provided that, when R 1 is the same as R 9 and R 2 is the same as R 7 , then R 8 is not hydrogen.
Claim 6
Dependent Claim
145 words
A complex of Technetium-99m with a propylene amine oxime, which complex has the formula wherein each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 is independently hydrogen, C 1 -C 8 straight- or branched-chain saturated or unsaturated alkyl, aralkyl, aryl, alkoxy, alkoxycarbonyl, alkylcarbonyl, alkylcarbonyloxy, primary secondary or tertiary amine or amide, or nitrile, or one or more of R 1 , R 2 ; R 3 , R 4 ; R 5 , R 6 ; R 7 , R 8 ; R 8 , R 9 are joined to form a fused or spiro carbocyclic or heterocyclic ring, provided that, when R 1 is the same as R 9 and R 2 is the same as R 7 , then R 8 is not hydrogen.
Claim 7
Dependent Claim
46 words
A complex as claimed in Claim 4, wherein each of R 1 , R 2 , R 7 , R 8 and R 9 is C1 to C4 alkyl, R 3 and R 6 are H, and R 4 and R 5 are H or methyl.
References Cited (Backward Citations)
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