EP0175617B1
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EP
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Antibody-therapeutic agent conjugates
Assignee: Cytogen Corp
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Filing: 1985-09-13
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Granted: 1991-10-30
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Expires: 2005-09-13
Abstract
No abstract record available.
Inventors
- 👤 John Walter Goers
- 👤 Chyi Lee
- 👤 Richard Charles Siegel
- 👤 Thomas Joseph Mckearn
- 👤 Hurley Dalton King
- 👤 Daniel James Coughlin
- 👤 John Dennis Rodwell
- 👤 Vernon Leon Alvarez
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-29 18:23
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/10; A61K51/1093; A61K41/00; A61K41/0042; A61K41/0057; A61K41/0071; A61K2121/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
222 words
An aqueous soluble antibody-therapeutic agent conjugate for a medical use, comprising : a therapeutic agent capable of acting as a photosensitizer, attached, either directly or via a linker, through a covalent bond to an antibody or antibody fragment to form an antibody-therapeutic agent conjugate having substantially the same immunoreactivity and immunospecificity as the unconjucated antibody or antibody fragment, wherein the covalent bond is selectively formed at a site located outside the antigen binding region of the antibody or antibody fragment and is formed between an amino group of the photosensitizer or linker and an aldehyde group of an oxidized carbohydrate moiety of an antibody or antibody fragment, and in which the therapeutic agent is a compound of the formula : wherein R is selected from the group consisting of an alkyl containing from 1 to 3 carbon atoms, a hydroxy alkyl containing from 1 to 3 carbon atoms, a carboxyl, an alkyl carboxyl in which the alkyl contains from 1 to 3 carbon atoms, a vinyl and an H, and R' and R 2 are NHNH 2 , or R' is OH and R 2 is NHNH 2 , or R' is NHNH 2 and R 2 is OH; or in which the therapeutic agent is a compound of the formula : wherein X is selected from the group consisting of and
Claim 2
Dependent Claim
222 words
An aqueous soluble antibody-therapeutic agent conjugate for a medical use, comprising : a therapeutic agent capable of acting as a photosensitizer, attached, either directly or via a linker, through a covalent bond to an antibody or antibody fragment to form an antibody-therapeutic agent conjugate having substantially the same immunoreactivity and immunospecificity as the unconjucated antibody or antibody fragment, wherein the covalent bond is selectively formed at a site located outside the antigen binding region of the antibody or antibody fragment and is formed between an amino group of the photosensitizer or linker and an aldehyde group of an oxidized carbohydrate moiety of an antibody or antibody fragment, and in which the therapeutic agent is a compound of the formula : wherein R is selected from the group consisting of an alkyl containing from 1 to 3 carbon atoms, a hydroxy alkyl containing from 1 to 3 carbon atoms, a carboxyl, an alkyl carboxyl in which the alkyl contains from 1 to 3 carbon atoms, a vinyl and an H, and R' and R 2 are NHNH 2 , or R' is OH and R 2 is NHNH 2 , or R' is NHNH 2 and R 2 is OH; or in which the therapeutic agent is a compound of the formula : wherein X is selected from the group consisting of and
Claim 3
Dependent Claim
27 words
The antibody-therapeutic agent conjugate according to claim 1, wherein the antibody fragment is selected from the group consisting of Fab fragments, (Fab') fragments and half antibody molecules.
Claim 4
Dependent Claim
20 words
The antibody-therapeutic agent conjugate according to claim 1, wherein the antibody is a monoclonal antibody or a monoclonal antibody fragment.
Claim 5
Dependent Claim
102 words
The antibody-therapeutic agent conjugate according to claim 1, whereing the therapeutic agent is an amine containing phorphyrin compound of the formula : wherein R is selected form the group consisting of an alkyl containing from 1 to 3 carbon atoms, a hydroxy alkyl containing from 1 to 3 carbon atoms, a carboxyl, an alkyl carboxyl in which the alkyl contains from 1 to 3 carbon atoms, a vinyl and an H, and R' and R 2 are NHNH 2 , or R' is OH and R 2 is NHNH 2 , or R 1 is NHNH 2 and R 2 is OH.
Claim 6
Dependent Claim
31 words
The antibody-therapeutic agent conjugate according to claim 1, wherein the therapeutic agent is an amine containing erythrosin-derivative of the formula : wherein X is selected from the group consisting of and
References Cited (Backward Citations)
JPS52141882A
Cited
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