EP0175270A2
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EP
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Prognostic value of rheumatoid factor isotypes and their association with disease activity
Assignee: TEITSSON, INGVAR
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Filing: 1985-09-11
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Granted: —
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Expires: 2005-09-11
Abstract
Abstract The levels of the IgA and IgM isotypes of rheumatoid factor (RF) in the blood of an individual afflicted with rheumatoid arthritis have been found to correlate with prognosis for the course of the disease. Those individuals showing above normal levels of IgA RF proceeded to a severe disease state with the appearance of bone erosions while those showing above normal levels of IgM RF did not proceed to such a severe state. Furthermore, disease activity in such individuals has been found to correlate with fluctuations in the level of IgA RF in the blood.
Inventors
- 👤 Helgi Valdimarsson
- 👤 Ingvar Teitsson
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 09:43
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/564; G01N33/563; G01N2800/00; G01N2800/10; G01N2800/101; G01N2800/102
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
79 words
A method for aiding the prognosis of individuals afflicted with rheumatoid arthritis, characterized in that: (a) the level of the IgA isotype of rheumatoid factor (RF) in the blood of such individuals is measured, and (b) such measured IgA RF level is compared with the level of normal individuals, whereby a substantially increased level of IgA RF in the tested individual indicates a likelihood that the disease will proceed to a severe state with the appearance of bone erosins.
Claim 2
Independent Claim
79 words
A method for aiding the prognosis of individuals afflicted with rheumatoid arthritis, characterized in that: (a) the level of the IgA isotype of rheumatoid factor (RF) in the blood of such individuals is measured, and (b) such measured IgA RF level is compared with the level of normal individuals, whereby a substantially increased level of IgA RF in the tested individual indicates a likelihood that the disease will proceed to a severe state with the appearance of bone erosins.
Claim 3
Dependent Claim
21 words
The method of Claim 1 characterized in that the level of IgA is measured by immunoassay, preferably an enzyme-linked immunosorbent assay.
Claim 4
Dependent Claim
82 words
The method of Claim 2 characterized in that the assay comprises the steps of contacting a sample of serum obtained from the blood of the individual being tested with a solid phase comprising insolubilized normal rabbit IgG, after a predetermined incubation contacting the solid phase with the F(ab') 2 fraction of antihuman IgA labeled with an enzyme, after a predetermined second incubation contacting the solid phase with the substrate for the enzyme which yields a detectable optical response, and measuring such response.
Claim 5
Independent Claim
74 words
A method for aiding the prognosis of individuals afflicted with rheumatoid arthritis characterized in that: (a) the level of the IgM isotype of rheumatoid factor (RF) in the blood of such individuals is measured, and (b) such measured IgM RF level is compared with the level of normal individuals, whereby a substantially increased level of IgM RF in the tested individual indicates a likelihood that the disease will not proceed to a severe state.
Claim 6
Independent Claim
74 words
A method for aiding the prognosis of individuals afflicted with rheumatoid arthritis characterized in that: (a) the level of the IgM isotype of rheumatoid factor (RF) in the blood of such individuals is measured, and (b) such measured IgM RF level is compared with the level of normal individuals, whereby a substantially increased level of IgM RF in the tested individual indicates a likelihood that the disease will not proceed to a severe state.
Claim 7
Dependent Claim
22 words
The method of Claim 4 characterized in that the level of IgM RF is measured by immunoassay, preferably an enzyme-linked immunosorbent assay.
Claim 8
Dependent Claim
75 words
The method of Claim 5`characterized in'that the assay comprises the steps of contacting a sample of serum obtained from the blood of the individual being tested with a solid phase comprising insolubilized normal rabbit IgG, after a predetermined incubation contacting the solid phase with anti-human IgM labeled with an enzyme, after a predetermined second incubation contacting the solid phase with the substrate for the enzyme which yields a detectable optical response, and measuring such response.
Claim 9
Independent Claim
81 words
A method for aiding the assessment of rheumatoid arthritis disease activity in individuals having the disease, characterized in that: (a) the level of the IgA isotype of rheumatoid factor (RF) in the blood of such individual is measured, and (b) such measured IgA RF level is compared with such levels measured over a prior period of time, whereby significant increase or decrease of such level with respect to the prior measured levels indicates an increase or decrease, respectively, in disease activity.
Claim 10
Independent Claim
81 words
A method for aiding the assessment of rheumatoid arthritis disease activity in individuals having the disease, characterized in that: (a) the level of the IgA isotype of rheumatoid factor (RF) in the blood of such individual is measured, and (b) such measured IgA RF level is compared with such levels measured over a prior period of time, whereby significant increase or decrease of such level with respect to the prior measured levels indicates an increase or decrease, respectively, in disease activity.
Claim 11
Dependent Claim
20 words
The method of Claim 7 wherein the level of IgA RF is measured by immunoassay, preferably an enzyme-linked immunosorbent assay.
References Cited (Backward Citations)
No citation records indexed.
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