EP0171887A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Anti-diabetic compounds
Assignee: Eli Lilly and Co
•
Filing: 1985-06-12
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Granted: —
•
Expires: 2005-06-12
Abstract
Abstract Compounds having the formula in which X is present or absent, and, if present, is -R-R or -R-R-E-A-E-D-L-Q-V-G-0-V-E-L--G-G-G,P-G-A-G-S-L-0-P-L, and pharmaceutically-acceptable salts thereof, have insulin-like activity.
Inventors
- 👤 Bruce Hill Frank
- 👤 Allen Howard Pekar
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 09:44
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/62; A; A61; A61P; A61P3/00; A61P3/08; A61P3/10; A61P5/00; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/26
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
22 words
A compound of the formula (I); in which X is present or absent, and, if present, is or a pharmaceutically-acceptable salt thereof.
Claim 2
Dependent Claim
22 words
A compound of the formula (I); in which X is present or absent, and, if present, is or a pharmaceutically-acceptable salt thereof.
Claim 3
Dependent Claim
15 words
A compound of formula (I) as claimed in claim 1, in which X is -R-R.
Claim 4
Dependent Claim
15 words
A compound of formula (I) as claimed in claim 1, in which X is -R-R-E-A-E-D-L-Q-V-G-Q-V-E-L-G-G-G-P-G-A-G-S-L-Q-P-L.
Claim 5
Dependent Claim
15 words
A compound of formula (I) as claimed in claim 1, in which X is absent.
Claim 6
Dependent Claim
36 words
A pharmaceutically-acceptable formulation including as an active ingredient a compound of formula (I) as claimed in any one of claims 1 to 4, or a pharmaceutically-acceptable salt thereof, associated with one or more pharmaceutically-acceptable carriers therefor.
Claim 7
Dependent Claim
180 words
A process for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof, as claimed in claim 1 which comprises: (A) treating human proinsulin with chymotoypsin so as to produce a compound of formula (I) in which X is (B) treating: with chymotrypsin to yield a compound of formula (I) in which X is R-R; or (C) treating a compound of formula (I) in which X is R-R with carboxypeptidase B so as to produce a compound of formula (I) in which X is absent. A process for preparing a compound of the formula (I): in which X is present or absent, and, if present, is or a pharmaceutically-acceptable salt thereof which comprises: (A) treating human proinsulin with chymotoypsin so as to produce a compound of formula (I) in which X is (B) treating: with chymotrypsin to yield a compound of formula (I) in which X is R-R; or (C) treating a compound of formula (I) in which X is R-R with carboxypeptidase B so as to produce a compound of formula (I) in which X is absent.
References Cited (Backward Citations)
No citation records indexed.
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