EP0171742A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Transdermal delivery of opioids
Assignee: EIDP Inc
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Filing: 1985-08-07
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Granted: —
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Expires: 2005-08-07
Abstract
Abstract Opioid-containing pharmaceutical compositions are provided which are useful in effecting transdermal delivery of a therapeutic dose of the opioid to the systemic circulation of a mammal. These pharmaceutical compositions consist essentially of the opioid, a penetration enhancer which is at least one of a saturated fatty alcohol or fatty acid of 8-15 carbon atoms or of a unsaturated fatty alcohol or fatty acid of 8-18 carbon atoms, and a suitable pharmaceutical carrier, preferably propylene glycol. Related application This application is a continuation-in-part of copending application U.S. Serial No 639, 385 filed August 10, 1984.
Inventors
- 👤 Bruce Aungst
- 👤 Robert Cosmo Di Luccio
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-27 22:17
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61K31/485; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/12; A61K47/30; A61K47/36; A61K47/38; A61K9/00; A61K9/0012; A61K9/0014; A61K9/70; A61K9/7023
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
80 words
A pharmaceutical composition effective in producing transdermal delivery of a therapeutically effective amount of an opioid to the systemic circulation of a mammal, the composition consisting essentially of a therapeutically effective amount of an opioid or a pharmaceutically acceptable salt thereof; an effective penetration enhancing amount of at least one of a saturated fatty alcohol or fatty acid of 8-15 carbon atoms or of an unsaturated fatty alcohol or fatty acid of 8-18 carbon atoms; and a suitable pharmaceutical carrier.
Claim 2
Dependent Claim
80 words
A pharmaceutical composition effective in producing transdermal delivery of a therapeutically effective amount of an opioid to the systemic circulation of a mammal, the composition consisting essentially of a therapeutically effective amount of an opioid or a pharmaceutically acceptable salt thereof; an effective penetration enhancing amount of at least one of a saturated fatty alcohol or fatty acid of 8-15 carbon atoms or of an unsaturated fatty alcohol or fatty acid of 8-18 carbon atoms; and a suitable pharmaceutical carrier.
Claim 3
Dependent Claim
57 words
A composition according to Claim 1 wherein the opioid is a natural or synthetic opioid analgesic such as morphine, oxymorphone, fentanyl, meperidine. propoxyphene. or oxycodone; a natural or synthetic narcotic antagonist such as nalmefene. naloxone. or naltrexone; a natural or synthetic mixed opioid agonist/antagonist such as nalbuphine. butorphanol, buprenorphine or pentazocine; or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
35 words
A composition according to Claim 2 wherein the saturated fatty alcohol or fatty acid has from 10 to 15 carbon atoms and the unsaturated fatty alcohol or fatty acid has 10 to 15 carbon atoms.
Claim 5
Dependent Claim
17 words
A composition according to Claim 3 wherein the fatty alcohol or fatty acid has 14 carbon atoms.
Claim 6
Dependent Claim
23 words
A composition according to Claim 4 wherein the fatty acid or fatty alcohol is myristic acid or myristic alcohol or a mixture thereof.
Claim 7
Dependent Claim
30 words
A composition according to Claim 5 wherein the pharmaceutical carrier is a non-toxic pharmaceutically suitable vehicle which comprises a polar protic solvent with a molecular weight of less than 600.
Claim 8
Dependent Claim
12 words
A composition according to Claim 6 wherein the vehicle is propylene glycol.
Claim 9
Dependent Claim
15 words
A composition according to Claim 3 wherein the composition is in lotion or cream form.
Claim 10
Dependent Claim
35 words
A composition according to Claim 8 which comprises 1 to 15% opioid, 30 to 80% vehicle, and 5 to 45% fatty acid or fatty alcohol or a mixture thereof, and the balance being an excipient.
Claim 11
Dependent Claim
35 words
A composition according to Claim 8 which comprises 5 to 15% opioid, 30 to 80% propylene glycol, 2 to 25% fatty acid or fatty alcohol or a mixture thereof, and the balance being an excipient.
Claim 12
Dependent Claim
21 words
A composition according to Claim 9 which further comprises water and an emulsifying agent to provide a composition in emulsion form.
Claim 13
Dependent Claim
14 words
A composition according to Claim 11 which contains from about 30 to 50% water.
Claim 14
Dependent Claim
19 words
A composition according to Claim 9 which further comprises a polymeric substance to provide a composition in gel form.
Claim 15
Dependent Claim
15 words
A composition according to Claim 13 which contains from about 20 to 30% polymeric substance.
Claim 16
Dependent Claim
17 words
A composition according to Claim 14 wherein the polymeric substance is ethylcellulose. hydroxypropylcellulose or a mixture thereof.
References Cited (Backward Citations)
No citation records indexed.
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