EP0166611A2
Expired / Lapsed
EP
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Stabilization of aqueous solutions of 5-chloro-3-isothiazolones
Assignee: Rohm and Haas Co
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Filing: 1985-06-26
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Granted: —
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Expires: 2005-06-26
Abstract
Abstract 5-Chloro-3-isothiazolone solutions containing 0.5 to 7% of the isothiazolone, 0.5 to 14% water and 0.15 to 7% of neutralization salt are stabilized against decomposition by formulating with 68 to 99% of solvent of one or more of the formulae: wherein R and R' are hydrogen or lower alkyl, X is -CH 2 OCH 2 -, (CH 2 ) n wherein n is an integer of 1 to 4 and y is an integer of 1 to 150, the percentage being by weight of the four components. The solutions can also contain stabilization salt in an amount of 0.01 to 2% by weight of the five components.
Inventors
- 👤 David Richard Amick
- 👤 Sidney Melamed
- 👤 Ernest Deiter Weiler
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 15:14
CPC Classifications
C; C07; C07D; C07D275/00; C07D275/02; C07D275/03; A; A01; A01N; A01N43/00; A01N43/72; A01N43/80; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/34; A61K8/345; A61K8/49; A61Q; A61Q17/00; A61Q17/005; A61K2800/00; A61K2800/40; A61K2800/52; A61K2800/524; A61Q5/00; A61Q5/02
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
144 words
A stabilized solution of an isothiazolone of the formula wherein Y is an unsubstituted alkyl of 1 to 8 carbon atoms, an unsubstituted or halo substituted alkenyl or alkynyl of 2 to 8 carbon atoms, an unsubstituted or substituted cycloalkyl of 5 to 8 carbon atoms, an unsubstituted or substituted aralkyl, or an unsubstituted or substituted aryl; R is hydrogen, halo, or (C 1 -C 4 )alkyl; comprising 0.5 to 7% of the isothiazolone, 0.5 to 14% of water; 68 to 99% by weight of hydroxy solvent of the formulae: wherein R and R 1 are hydrogen or lower alkyl, X is -CH 2 OCH 2 -, (CH 2 ) n wherein n is an integer of 1 to 4 and y is an integer of 1 to 150,and 0.15 to 7% of neutralization salt, the percentages being by weight of the four components.
Claim 2
Dependent Claim
144 words
A stabilized solution of an isothiazolone of the formula wherein Y is an unsubstituted alkyl of 1 to 8 carbon atoms, an unsubstituted or halo substituted alkenyl or alkynyl of 2 to 8 carbon atoms, an unsubstituted or substituted cycloalkyl of 5 to 8 carbon atoms, an unsubstituted or substituted aralkyl, or an unsubstituted or substituted aryl; R is hydrogen, halo, or (C 1 -C 4 )alkyl; comprising 0.5 to 7% of the isothiazolone, 0.5 to 14% of water; 68 to 99% by weight of hydroxy solvent of the formulae: wherein R and R 1 are hydrogen or lower alkyl, X is -CH 2 OCH 2 -, (CH 2 ) n wherein n is an integer of 1 to 4 and y is an integer of 1 to 150,and 0.15 to 7% of neutralization salt, the percentages being by weight of the four components.
Claim 3
Dependent Claim
23 words
A solution according to claim 1 also containing stabilization salt in an amount of 0.01 to 2% by weight of the five components.
Claim 4
Dependent Claim
45 words
A solution according to claim 1 wherein the isothiazolone content is 1 to 2% by weight, the water content is 1 to 4% by weight, the solvent content is 92 to 97.7% by weight and the neutralization salt content is 0.3 to 2% by weight.
Claim 5
Dependent Claim
23 words
A solution according to claim 3 also containing stabilization salt in an amount of 0.01 to 0.2% by weight of the five components.
Claim 6
Dependent Claim
21 words
A solution according to any preceding claim wherein the solvent comprises propylene glycol, dipropylene glycol, polypropylene glycol, 1,5-pentandiol and/or benzyl alcohol.
Claim 7
Dependent Claim
12 words
A solution according to any preceding claim wherein the isothiazolone comprises 5-chloro-2-methyl-4-isothiazolin-3-one.
Claim 8
Dependent Claim
18 words
A solution according to claim 5 wherein the neutralization salt comprises copper chloride, sodium chloride and/or magnesium chloride.
Claim 9
Independent Claim
168 words
A method producing a stable solution containing isothiazolone of the formula: wherein Y is an unsubstituted or substituted (C 1 to C 8 )-alkyl, an unsubstituted or halo substituted ( C 2 to C 8 )-alkenyl or (C 2 to C 8 )-alkynyl group, an unsubstituted or substituted (C 5 to Cg)-cycloalkyl, an unsubstituted or substituted aralkyl group or an unsubstituted or substituted aryl group; R is hydrogen, halo, or (C 1 -C 4 )-alkyl group; which comprises formulating the solution to contain (1) 0.5 to 7% isothiazolone, (2) 0.5 to 14% by weight of water, (3) from 68 to 99% by weight of solvent of the formula wherein R and R 1 are hydrogen or lower alkyl, X is -CH 2 OCH 2 -, (CH 2 ) n wherein n is an integer of 1 to 4 and y is an integer of 1 to 150: and (4) 0.15 to about 7% by weight of neutralization salt; the percentages being by weight of the four stated components.
Claim 10
Independent Claim
168 words
A method producing a stable solution containing isothiazolone of the formula: wherein Y is an unsubstituted or substituted (C 1 to C 8 )-alkyl, an unsubstituted or halo substituted ( C 2 to C 8 )-alkenyl or (C 2 to C 8 )-alkynyl group, an unsubstituted or substituted (C 5 to Cg)-cycloalkyl, an unsubstituted or substituted aralkyl group or an unsubstituted or substituted aryl group; R is hydrogen, halo, or (C 1 -C 4 )-alkyl group; which comprises formulating the solution to contain (1) 0.5 to 7% isothiazolone, (2) 0.5 to 14% by weight of water, (3) from 68 to 99% by weight of solvent of the formula wherein R and R 1 are hydrogen or lower alkyl, X is -CH 2 OCH 2 -, (CH 2 ) n wherein n is an integer of 1 to 4 and y is an integer of 1 to 150: and (4) 0.15 to about 7% by weight of neutralization salt; the percentages being by weight of the four stated components.
Claim 11
Dependent Claim
23 words
A method according to claim 8 as applied to the production of a solution according to any one of claims 2 to 7.
Claim 12
Dependent Claim
18 words
The use of a solution according to any of claims 1 to 7 as a biocide or preservative.
References Cited (Backward Citations)
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