EP0166263A1
Expired / Lapsed
EP
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Filler composition for filling in defect or hollow portion of bone and kit or set for the preparation of the filler composition
Assignee: Mitsubishi Mining and Cement Co Ltd
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Filing: 1985-05-30
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Granted: —
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Expires: 2005-05-30
Abstract
Abstract According to the present invention, a filler composition is provided. The filler composition is filled in a defect or hollow rortion of bone. The filler composition comprises fibrin and a calcium phosphate compound. The present invention also provides a kit or set for the preparation of the filler composition. The kit or set comprises at least two containers. One container includes fibrinogen and the other container includes thrombin. The kit or set further contains a calcium phosphate compound and calcium chloride.
Inventors
- 👤 Hisashi Kurosawa
- 👤 Kenichi Murase
- 👤 Hideo Nishimaki
- 👤 Shuzo Kitagawa
- 👤 Masayuki Nishida
- 👤 Mikiya Ono
- 👤 Hiroyasu Takeuchi
- 👤 Yoshitaka Ohkubo
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 13:33
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/0047; A61L24/0073; A61L24/0084; A61L27/00; A61L27/14; A61L27/22; A61L27/225; A61L27/40; A61L27/44; A61L27/46; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; A61F2310/00377; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
21 words
A filler composition to be filled in a defect or hollow portion of bone comprising fibrin and a calcium phosphate compound.
Claim 2
Dependent Claim
21 words
A filler composition to be filled in a defect or hollow portion of bone comprising fibrin and a calcium phosphate compound.
Claim 3
Dependent Claim
27 words
The composition according to claim 1, wherein said composition contains 5 to 95 vol% of said fibrin and 95 to 5 vol% of said calcium phosphate compound.
Claim 4
Dependent Claim
41 words
The composition according to claim 1 or 2, wherein said calcium phosphate compound is selected from the group consisting of tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, oxyapatite, calcium pyrophosphate, fluoroapatite, hydroxyapatite derivatives having hydroxyl groups substituted by fluorine ions, and mixtures thereof.
Claim 5
Dependent Claim
35 words
The composition according to any of the claims 1 to 3, wherein said calcium phosphate compound is in powder, particle form or in granule form and said powder, particle or granule is dispersed in fibrin.
Claim 6
Dependent Claim
16 words
The composition according to claim 4, wherein said powder, particle or granule is a baked material.
Claim 7
Dependent Claim
46 words
The composition according to any of the claims 1 to 3, wherein said calcium phosphate compound is in the form of porous mass having a multiplicity of continuous pores or channels of three-dimensional network structure and wherein said fibrin is filled in said pores or channels.
Claim 8
Dependent Claim
36 words
The composition according to any of the claims 1 to 6, wherein said composition is stored in a liquid selected from the group consisting of isotonic sodium chloride solution and buffer solutions of low salt concentration.
Claim 9
Dependent Claim
31 words
8 . The composition according to any of the claims 1 to 7, wherein said fibrin is prepared by adding a coagulant or solidifier including thrombin and calcium chloride to fibrinogen.
Claim 10
Dependent Claim
37 words
The composition according to any of the claims 1 to 8, wherein said composition contains an inhibitor for proteinase, which preferably is selected from the group consisting of aprotinin, ε-aminocaproic acid, tranexamic acid and soybean trypsin inhibitor.
Claim 11
Dependent Claim
53 words
A kit or set for the preparation of a filler composition to be filled in a defect or hollow portion of bone, said kit or set comprising at least two containers, one container including fibrinogen and the other including thrombin, said kit or set further containing a calcium phosphate compound and calcium chloride.
Claim 12
Dependent Claim
53 words
A kit or set for the preparation of a filler composition to be filled in a defect or hollow portion of bone, said kit or set comprising at least two containers, one container including fibrinogen and the other including thrombin, said kit or set further containing a calcium phosphate compound and calcium chloride.
Claim 13
Dependent Claim
43 words
11 . The kit or set according to claim 10, wherein said calcium phosphate compound is selected from the group consisting of tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, oxyapatite, calcium pyrophosphate, fluoroapatite, hydroxyapatite derivatives having hydroxyl groups substituted by fluorine ions, and mixtures thereof.
Claim 14
Dependent Claim
22 words
The kit or set according to claim 10 or 11, wherein said calciun phosphate compound is in powder, particle or granule form.
Claim 15
Dependent Claim
18 words
The kit or set according to claim 12, wherein said powder, particles or granules is a baked material.
Claim 16
Dependent Claim
34 words
The kit or set according to claim 10 or 11, wherein said calcium phosphate compound is in the form of porous mass having a multiplicity of continuous pores or channels of three-dimensional network structure.
Claim 17
Dependent Claim
26 words
The kit or set according to any of the claims 10 to 14, wherein said fibrinogen is dried powder form fibrinogen, or is a fibrinogen solution.
Claim 18
Dependent Claim
35 words
The kit or set according to claim 15, wherein said fibrinogen solution is formed by dissolving fibrinogen in a liquid selected from the group consisting of distilled water and buffer solutions of low salt concentration.
Claim 19
Dependent Claim
37 words
The kit or set according to any of the claims 10 to 16, further comprising an inhibitor for proteinase, which preferably is selected from the group consisting of aprotinin, -aminocaproic acid, tranexamic acid and soybean trypsin inhibitor.
Claim 20
Dependent Claim
51 words
18 . The kit or set according to any of the claims 10 to 16, wherein said thrombin and said calcium chloride are dissolved in a liquid to form a mixed solution and said liquid is selected from the group consisting of isotonic sodium chloride solution and citric acid buffer solutions.
Claim 21
Dependent Claim
30 words
19 . The kit or set according to claim 18, wherein said mixed solution contains 1 to 500 NIH units/ml of thrombin and 10 to 100 millimols/ml of calcium chloride.
Claim 22
Dependent Claim
22 words
20 . The kit or set according to claim 18 or 19, wherein said mixed solution further contains an inhibitor for proteinase.
Claim 23
Dependent Claim
30 words
21 . The kit or set according to claim 20, wherein the content of said inhibitor for said proteinase in said mixed solution ranges within 100 to 5000 KIE units/ml.
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