EP0162724A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Vesicle stabilization
Assignee: Nexstar Pharmaceuticals Inc
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Filing: 1985-05-24
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Granted: —
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Expires: 2005-05-24
Abstract
Abstract Micelles are stabilized to improve their shelf life by suspending the micelles in a polymeric gel matrix which forms a protective gel surface around the micelles, the gel matrix being one transformable to a fluid to transform the protective surface to an aqueous suspension. The technique is particularly useful to stabilize phospholipid vesicles containing a therapeutic agent.
Inventors
- 👤 George Wing-Yiu Tin
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 21:32
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K51/00; A61K51/12; A61K51/1217; A61K51/1227; A61K51/1234; A61K2123/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
32 words
Micellular particles suspended in a polymeric gel matrix forming a protective gel surface thereabout, said gel matrix being capable of becoming fluid to convert said protective gel surface to an aqueous suspension.
Claim 2
Dependent Claim
32 words
Micellular particles suspended in a polymeric gel matrix forming a protective gel surface thereabout, said gel matrix being capable of becoming fluid to convert said protective gel surface to an aqueous suspension.
Claim 3
Dependent Claim
37 words
Micellular particles according to claim 1 in which said polymeric gel matrix is either a polysaccharide or a polypeptide capable of melting at approximately room temperature or above to transform said protective surface to an aqueous suspension.
Claim 4
Dependent Claim
14 words
Micellular particles according to claim 2 in which said polymeric gel matrix is gelatin.
Claim 5
Dependent Claim
14 words
Micellular particles according to claim 2 in which said polymeric gel matrix is agarose.
Claim 6
Dependent Claim
17 words
Micellular particles according to any one of the preceding claims in which said particles are phospholipid vesicles.
Claim 7
Dependent Claim
20 words
Micellular particles according to any one of the preceding claims in which said particles have a therapeutic agent enclosed therein.
Claim 8
Dependent Claim
30 words
Micellular particles according to any one of the preceding claims in which said polymeric gel matrix is a solution containing from about 0.5% to approximately 10% by weight polymeic gel.
Claim 9
Dependent Claim
26 words
Micellular particles according to claim 7 in which said polymeric gel matrix is a solution containing from about 1.0 to about 5.0 wt % polymeric gel.
Claim 10
Dependent Claim
34 words
A suspension of micellular particles obtained by transforming the gel matrix in particles according to any one of the preceding claims into an aqueous suspension and then labelling the particles with a diagnostic radionuclide.
Claim 11
Dependent Claim
59 words
A process of producing stabilized micellular particles of increased shelf life as defined in any one of claims 1 to 8, comprising suspending said particles in a polymeric gel matrix to form a protective gel surface about said particles, said gel matrix being capable of transformation into a fluid to transform said protective gel surface to an aqueous suspension.
References Cited (Backward Citations)
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