EP0160552A2
Expired / Lapsed
EP
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Contrast agents for NMR imaging
Assignee: Nexstar Pharmaceuticals Inc
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Filing: 1985-04-26
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Granted: —
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Expires: 2005-04-26
Abstract
Abstract An agent for contrast enhancement in nuclear magnetic resonance imaging comprises micellular particles such as phospholipid vesicles associated with or enclosing a paramagnetic material. The particles may be formulated with an agent, such as cholesterol, to promote vesicle stability and water exchange across the vesicle bilayer. The vesicles may or may not have antibodies or other cell recognition targeting agents attached to the surface to provide specific targeting. The vesicles provide enhanced target specificity, reduced burden of toxic contrast material and amplified contrast enhancement.
Inventors
- 👤 Ronald Carl Gamble
- 👤 Paul Gardner Schmidt
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 03:13
CPC Classifications
A; A61; A61K; A61K51/00; G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/5601; A61K49/00; A61K49/06; A61K49/18; A61K49/1806; A61K49/1812
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
13 words
Nuclear magnetic contrast agents comprising micellular particles having a paramagnetic material associated therewith.
Claim 2
Dependent Claim
13 words
Nuclear magnetic contrast agents comprising micellular particles having a paramagnetic material associated therewith.
Claim 3
Dependent Claim
26 words
A contrast agent according to claim 1 in which said paramagnetic material is associated with a chelating agent bound to the surface of said micellular particles.
Claim 4
Dependent Claim
18 words
A nuclear magnetic resonance contrast agent according to claim 1 comprising micellular particles with paramagnetic material encapsulated therein.
Claim 5
Dependent Claim
18 words
A contrast agent according to any one of the preceding claims in which said micellular particles are vesicles.
Claim 6
Dependent Claim
27 words
A contrast agent according to claim 4 in which said vesicles are formulated with an agent to promote vesicle stability and water exchange across the vesicle bilayer.
Claim 7
Dependent Claim
15 words
A contrast agent according to claim 5 in which said vesicles are formulated with cholesterol.
Claim 8
Dependent Claim
31 words
A contrast agent according to any one of the preceding claims in which antibodies, carbohydrates, or other cell recognition targeting agents are attached to said micellular particles, to provide specific targeting.
Claim 9
Dependent Claim
16 words
A contrast agent according to claim 7 in which said targeting agent is the antibody antimyosin.
Claim 10
Dependent Claim
16 words
A contrast agent according to claim 7 in which said targeting agent is the antibody antifibrin.
Claim 11
Dependent Claim
27 words
A contrast agent according to any one of the preceding claims in which said paramagnetic material is present in a concentration of at least approximately 50 mM.
Claim 12
Dependent Claim
29 words
A contrast agent according to any one of the preceding claims in which said paramagnetic material is present in a concentration of from about 50 mM to approximately 1M.
Claim 13
Dependent Claim
33 words
A contrast agent according to any one of the preceding claims in which said paramagnetic material is a salt of a transition metal or the lanthanide or actinide series of the Periodic Table.
Claim 14
Dependent Claim
30 words
A contrast agent according to claim 12 in which said paramagnetic material is a salt of a paramagnetic ion selected from manganese, copper, gadolinum, erbium, chromium, iron, cobalt and nickel.
Claim 15
Dependent Claim
25 words
A contrast agent according to claim 12 or 13 in which said paramagnetic material is a paramagnetic compound of a paramagnetic ion and a chelate.
Claim 16
Dependent Claim
23 words
A contrast agent according to claims 1 to 11 in which said paramagnetic material is a paramagnetic compound including a stable free radical.
Claim 17
Dependent Claim
29 words
A contrast agent according to any one of the preceding claims in which the efficiency of said paramagnetic material is enhanced by the addition of a charged polymer thereto.
Claim 18
Dependent Claim
14 words
A contrast agent according to claim 16 in which said charged polymer is poly-L-lysine.
Claim 19
Dependent Claim
25 words
A contrast agent according to any one of claims 1 to 11 in which said paramagnetic material is a paramagnetic ion associated with a chelate.
Claim 20
Dependent Claim
14 words
A contrast agent according to claim 16 in which said paramagnetic material is Gd-DTPA.
References Cited (Backward Citations)
No citation records indexed.
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