EP0159264A2
Expired / Lapsed
EP
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Antiviral compounds
Assignee: Merck and Co Inc
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Filing: 1985-04-04
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Granted: —
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Expires: 2005-04-04
Abstract
Abstract Purines and pyrimidines having a fused cyclopropane ring in the side chain and the heterocyclic isosteres of said purines and pyrimidines have antiviral activity, especially against viruses of the herpes class.
Inventors
- 👤 Wallace Ashton
- 👤 Edward Walton
- 👤 Richard Tolman
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-29 04:50
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/46; C07D239/47; A; A61; A61P; A61P31/00; A61P31/12; C07C; C07C255/00; C07D233/00; C07D233/54; C07D233/66; C07D233/90; C07D239/48; C07D239/50; C07D239/52; C07D239/54; C07D303/00; C07D303/02; C07D303/12; C07D303/16; C07D471/00; C07D471/02; C07D471/04; C07D473/00; C07D487/00; C07D487/02; C07D487/04
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
68 words
A compound of the formula and the pharmaceutically acceptable salts thereof wherein Y is a purin-9-yl or a pyrimidin-1-yl or a heterocyclic isostere of a purin-9-yl or a pyrimidin-1-yl group; R 1 is selected from hydrogen and alkyl of 1 to 4 carbon atoms; R 2 is selected from hydrogen, alkyl of 1 to 4 carbon atoms, and -CH 2 OH; and Z is -CH 2 or -O.
Claim 2
Dependent Claim
68 words
A compound of the formula and the pharmaceutically acceptable salts thereof wherein Y is a purin-9-yl or a pyrimidin-1-yl or a heterocyclic isostere of a purin-9-yl or a pyrimidin-1-yl group; R 1 is selected from hydrogen and alkyl of 1 to 4 carbon atoms; R 2 is selected from hydrogen, alkyl of 1 to 4 carbon atoms, and -CH 2 OH; and Z is -CH 2 or -O.
Claim 3
Dependent Claim
15 words
A compound according to Claim 1 wherein Y is a purin-9-yl or a pyrimidin-1-yl group.
Claim 4
Dependent Claim
9 words
A compound according to Claim 1 wherein Y is
Claim 5
Dependent Claim
9 words
A compound according to Claim 1 wherein Y is
Claim 6
Dependent Claim
9 words
A compound according to Claim 1 wherein Y is
Claim 7
Dependent Claim
9 words
A compound according to Claim 1 wherein Y is
Claim 8
Dependent Claim
9 words
A compound according to Claim 1 wherein Y is
Claim 9
Dependent Claim
5 words
9-[(Z)-2-(Hydroxymethyl)cyclopropylmethyl]guanine, according to Claim 1.
Claim 10
Dependent Claim
24 words
An antiviral pharmaceutical composition comprising an effective amount of a compound according to anyone of Claim 1 to 7 and a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
47 words
A compound of the formula wherein Q is H or ; W is H, -N=O, or -NH 2 ; R 1 is hydrogen or alkyl of 1 to 4 carbon atoms; and R 2 is hydrogen, alkyl of 1 to 4 carbon atoms or -CH 2 OH.
Claim 12
Dependent Claim
47 words
A compound of the formula wherein Q is H or ; W is H, -N=O, or -NH 2 ; R 1 is hydrogen or alkyl of 1 to 4 carbon atoms; and R 2 is hydrogen, alkyl of 1 to 4 carbon atoms or -CH 2 OH.
Claim 13
Dependent Claim
10 words
A compound according to Claim 10 wherein Q is H.
References Cited (Backward Citations)
No citation records indexed.
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