EP0159168A2
Expired / Lapsed
EP
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Soft patch drug preparation
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1985-04-04
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Granted: —
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Expires: 2005-04-04
Abstract
Abstract Drug preparations for external application having a stick-itself-to-the-skin property, so-called "soft patch", are provided. The preparations contain a drug, a water-soluble protein having an absorption-promoting effect, a polyhydric alcohol, a tackifier, and an oleaginous substance, and ensure an improved percutaneous absorption and bioavailability of the drugs, thus permitting an accurate control of drug dosage.
Inventors
- 👤 Kazuo Kigasawa
- 👤 Hideaki Ohtani
- 👤 Makoto Tanaka
- 👤 Shigeru Hayashida
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-27 18:59
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61K9/7007; A61K9/7061; A61K9/7069
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
47 words
A soft pharmaceutical preparation for external application which contains the following components (a), (b), (c), (d) and (e) and has a stick-itself-to-the-skin property: (a) a drug; (b) a water-soluble protein having an absorption promoting effect; (c) a polyhydric alcohol; (d) a tackifier; and (e) an oleaginous substance.
Claim 2
Dependent Claim
47 words
A soft pharmaceutical preparation for external application which contains the following components (a), (b), (c), (d) and (e) and has a stick-itself-to-the-skin property: (a) a drug; (b) a water-soluble protein having an absorption promoting effect; (c) a polyhydric alcohol; (d) a tackifier; and (e) an oleaginous substance.
Claim 3
Dependent Claim
28 words
A pharmaceutical preparation according to claim 1, wherein an amount of the oleaginous substance is 0.5 to 20 weight percent, based on the weight of the whole composition.
Claim 4
Dependent Claim
29 words
A pharmaceutical preparation according to claim 1 or 2, wherein an amount of the drug is 0.05 to 10 weight percent, based on the weight of the whole composition.
Claim 5
Dependent Claim
31 words
A pharmaceutical preparation according to claim 1, 2 or 3, wherein an amount of the water-soluble protein is 5 to 35 weight percent, based on the weight of the whole composition.
Claim 6
Dependent Claim
31 words
A pharmaceutical preparation according to any one of the preceding claims, wherein an amount of polyhydric alcohol is 5 to 35 weight percent, based on the weight of the whole composition.
Claim 7
Dependent Claim
31 words
A pharmaceutical preparation according to any one of the preceding claims, wherein an amount of the tackifier is 0.3 to 10 weight percent, based on the weight of the whole composition.
Claim 8
Dependent Claim
15 words
A pharmaceutical preparation according to any one of the preceding claims, which also contains water.
Claim 9
Dependent Claim
33 words
A pharmaceutical preparation according to any one of the preceding claims, wherein the oleaginous substance is selected from esters of fatty acids, aliphatic higher alcohols, paraffin oils, lanolin oil, silicone oil and Plastibase.
Claim 10
Dependent Claim
65 words
A pharmaceutical preparation according to claim 8, wherein the oleaginous substance is one or more selected from esters of medium to higher fatty acids containing 6 to 20 carbon atoms and aliphatic monools or triols containing 1 to 20 carbon atoms, or polyols containing 4 to 8 hydroxyl groups; aliphatic higher alcohols containing 14 to 20 carbon atoms; fluid paraffin; white petroleum; lanolin; and silicone.
Claim 11
Dependent Claim
44 words
A pharmaceutical preparation according to claim 9, wherein the oleaginous substance is a triglyceride of a medium to higher fatty acid containing 6 to 20 carbon atoms or an ester of said fatty acid and an aliphatic monool containing 1 to 20 carbon atoms.
Claim 12
Dependent Claim
51 words
A pharmaceutical preparation according to any one of the preceding claims, wherein the drug is selected from drugs which exerts action on circulatory system, nervous system, endocrine system, respiratory system, metabolic system, urinary organ system or digestive organ system, antimicrobial agents, anti-tumor agents, vitamins, antidiabetics, enzymes, herb medicines and/or crude extracts.
Claim 13
Dependent Claim
33 words
A pharmaceutical preparation according to any one of the preceding claims, wherein the water-soluble protein is selected from animal proteins, vegetable proteins or peptides, preferably from gelatin, solubilizable collagen, casein and soybean protein.
Claim 14
Dependent Claim
23 words
A pharmaceutical preparation according to any one of the preceding claims, wherein the polyhydric alcohol has 2 to 6 of alcoholic hydroxyl groups.
Claim 15
Dependent Claim
43 words
A pharmaceutical preparation according to any one of the preceding claims, wherein the tackifier is selected from cellulose derivatives, polysaccharides, carboxyvinyl polymers, polyvinyl alcohol and/or polyvinylpyrrolidone, preferably sodium alginate, sodium polyacrylate, alkyl cellulose, hydroxyalkyl cellulose, Karaya gum, carrageenan, polyvinyl alcohol, polyvinylpyrrolidone and Pluran.
Claim 16
Dependent Claim
23 words
A pharmaceutical preparation according to any one of the preceding claims, which also contains adsorption promoting auxiliaries, preservatives, emulsified-dispersants, pH-controlling agent and/or colors.
References Cited (Backward Citations)
No citation records indexed.
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