EP0158996A2
Expired / Lapsed
EP
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Perfluoro carbon compound aqueous dispersions
Assignee: Affinity Biotech Inc
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Filing: 1985-04-12
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Granted: —
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Expires: 2005-04-12
Abstract
Abstract Compositions having enhanced gas and drug transporting capability, are prepared by providing a perfluoro compound dispersed in an aqueous medium with a surfactant to form an aqueous initial dispersion, concentrating the perfluoro compound phase of the dispersion as by centrifugation or filtration, wherein a portion of the surfactant remains complexed with the particles of the peifluoro compound phase and the balance of the surfactant is in the aqueous phase, separating the phases, and redispersing the particles of the concentrated perfluoro compound phase to form a final dispersion in which a major portion of the surfactant is complexed with the perfluoro compound particles.
Inventors
- 👤 William Mccormick
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 22:21
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61K31/25; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K9/10
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
37 words
A gas and drug transporting composition comprising a stable, uniform, aqueous dispersion of a perfluoro compound and a principal surfactant, wherein at least a major proportion of the principal surfactant present is complexed with the perfluoro compound.
Claim 2
Dependent Claim
37 words
A gas and drug transporting composition comprising a stable, uniform, aqueous dispersion of a perfluoro compound and a principal surfactant, wherein at least a major proportion of the principal surfactant present is complexed with the perfluoro compound.
Claim 3
Dependent Claim
22 words
A composition according to claim 1, wherein at least 75% by weight of the principal surfactant is complexed with the perfluoro compound.
Claim 4
Dependent Claim
40 words
A composition according to either of the preceding claims, wherein the amount of the perfluoro compound is - about 20-75% by weight of the dispersion and the amount of the principal surfactant is about 0.1-3.0% by weight of the dispersion.
Claim 5
Dependent Claim
44 words
The composition of any one of the preceding claims, wherein the perfluorocompound is a non-aromatizable perfluorinated C 9 -C 18 polycyclic hydrocarbon containing at least two bridgehead carbon atoms linked through a bridge containing at least one carbon atom, and the surfactant is nonionic.
Claim 6
Dependent Claim
17 words
A composition according to claim 4, wherein the perfluorocompound comprises a mixture of F-dimethyladamantane and F-trimethylbicyclo[3.3.1] nonane.
Claim 7
Dependent Claim
29 words
A composition according to any one of the preceding claims, wherein the surfactant is a fluorinated amidoamine oxide compound or a polyoxyethylene, polyoxypropylene or copolymer thereof or a phospholipid.
Claim 8
Dependent Claim
18 words
A composition according to any one of the preceding claims, wherein the dispersion additionally contains an auxiliary surfactant.
Claim 9
Dependent Claim
90 words
A process for preparing an aqueous dispersion of a perfluorocompound, which comprises: (a) providing an initial dispersion comprising (i) a perfluoro compound phase containing principal surfactant complexed with the perfluoro compound, and (ii) an aqueous phase containing free principal surfactant; (b) concentrating the perfluoro compound phase; (c) separating all or a portion of the aqueous phase from the concentrated perfluoro compound phase; (d) redispersing the concentrated perfluoro compound phase with an amount of an aqueous medium effective to redisperse the perfluoro compound phase and thereby to form a final dispersion.
Claim 10
Dependent Claim
90 words
A process for preparing an aqueous dispersion of a perfluorocompound, which comprises: (a) providing an initial dispersion comprising (i) a perfluoro compound phase containing principal surfactant complexed with the perfluoro compound, and (ii) an aqueous phase containing free principal surfactant; (b) concentrating the perfluoro compound phase; (c) separating all or a portion of the aqueous phase from the concentrated perfluoro compound phase; (d) redispersing the concentrated perfluoro compound phase with an amount of an aqueous medium effective to redisperse the perfluoro compound phase and thereby to form a final dispersion.
Claim 11
Dependent Claim
22 words
The process of claim 8, wherein substantially all of the aqueous phase is separated from the perfluoro compound phase in step (c).
Claim 12
Dependent Claim
30 words
The process of either of claims Sand 9, wherein an auxiliary surfactant is added in step (d) in an amount effective to promote redispersion of the concentrated perfluoro compound phase.
Claim 13
Dependent Claim
19 words
A process according to any one of claims 8-10, wherein the concentrating of step (b) is effected by centrifugation.
Claim 14
Dependent Claim
28 words
A process according to any one of claims 8-11, wherein the amount of principal surfactant in the final dispersion is less than the amount in the initial dispersion.
Claim 15
Dependent Claim
30 words
A process according to any one of claims 8-12, wherein the initial dispersion is prepared by agitating a mixture of perfluoro compound and a principal surfactant in an aqueous medium.
Claim 16
Dependent Claim
74 words
A process according to any one of claims 8-13, wherein the perfluoro compound phase separated in step (c) from the initial dispersion is characterized by a range of particle sizes, and wherein the particles are classified into desired and undesired particle size range materials, and the desired particle size range material is redispersed in step (d) and the undesired particle size range material is optionally-recycled to said mixture for preparation of said initial dispersion.
Claim 17
Dependent Claim
24 words
A process according to any one of claims 8-14, wherein the composition obtained is a product according to either of claims 5 and 6.
References Cited (Backward Citations)
No citation records indexed.
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