EP0154447A2
Expired / Lapsed
EP
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Compositions and method for improving wound healing
Assignee: University of California Berkeley
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Filing: 1985-02-20
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Granted: —
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Expires: 2005-02-20
Abstract
Abstract The healing of wounds is promoted by contacting the wound surfaces with a suspension of collagen and a glycosaminoglycan that is chemotactic for fibroblasts and/or endothelial cells. Typical glycosaminoglycans that exhibit the desired chemotaxis are heparin, heparan sulfate, and alginate. Two or more glycosaminoglycans can be present in the suspensions. Collagen is present in the suspension in the order of 7-10 mg/ml; while the glycosaminoglycan is present in much lower concentrations, e.g, 250-350 µg/ml. Application of the collagen/glycosaminoglycan suspension to open wounds greatly increases the rate of healing.
Inventors
- 👤 Dov Michaeli
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 11:21
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/39; A61P; A61P17/00
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
33 words
A composition for use in promoting the healing of wounds characterized in that it includes a suspension of collagen in admixture with a glycosaminoglycan that exhibits a chemotactic effect on tissue repair cells.
Claim 2
Dependent Claim
33 words
A composition for use in promoting the healing of wounds characterized in that it includes a suspension of collagen in admixture with a glycosaminoglycan that exhibits a chemotactic effect on tissue repair cells.
Claim 3
Dependent Claim
16 words
The compositon according to claim 1 wherein two or more glycosaminoglycans are present in the suspension.
Claim 4
Dependent Claim
27 words
The composition according to claim 1 or claim 2 wherein collagen is present in the suspension at a concentration of about 7 to 10 milligrams per milliliter.
Claim 5
Dependent Claim
32 words
The composition according to claim 1, claim 2 or claim 3 wherein the glycosaminoglycan is present in the suspension at a concentration of from about 100 to about 1000 micrograms per milliliter.
Claim 6
Dependent Claim
28 words
The commposition according to any one of the preceding claims wherein the ratio of the concentration of collagen to the concentration of glycosaminoglycan is about 25-35 to 1.
Claim 7
Dependent Claim
19 words
The composition according to claim 5 wherein the glycosaminoglycan or one of the glycosaminoglycans is heparin or heparin sulfate.
Claim 8
Dependent Claim
17 words
The composition according to claim 5 wherein the glycosaminoglycan or one of the glycosaminoglycans is an alginate.
Claim 9
Dependent Claim
21 words
A composition consisting essentially of a major amount of collagen in admixture with a minor amount of heparin and/or of alginate.
Claim 10
Dependent Claim
21 words
A composition consisting essentially of a major amount of collagen in admixture with a minor amount of heparin and/or of alginate.
Claim 11
Dependent Claim
15 words
The composition according to claim 8 wherein the composition is chemotactic for tissue repair cells.
Claim 12
Dependent Claim
32 words
The composition according to claim 9 wherein collagen is present at about 7-10 milligrams per milliliter and the heparin or alginate or mixture thereof is present at about 250-350 micrograms per milliliter.
Claim 13
Independent Claim
27 words
A method of promoting the healing of wounds characterized in that a composition according to any one of the preceding claims is applied to the wound surface.
Claim 14
Dependent Claim
6 words
CLAIMS FOR THE CONTRACTING STATE AT
Claim 15
Dependent Claim
35 words
Method of preparing a composition for use in promoting the healing of wounds characterized in forming the preparation with a suspension of collagen and a glycosaminoglycan that exhibits a chemotactic effect on tissue repair cells.
Claim 16
Dependent Claim
35 words
Method of preparing a composition for use in promoting the healing of wounds characterized in forming the preparation with a suspension of collagen and a glycosaminoglycan that exhibits a chemotactic effect on tissue repair cells.
Claim 17
Dependent Claim
15 words
Method according to claim 1 wherein two or more glycosaminoglycans are present in the suspension.
Claim 18
Dependent Claim
28 words
3 . Method according to claim 1 or claim 2 wherein collagen is present in the suspension at a concentration of about 7 to 10 milligrams per milliliter.
Claim 19
Dependent Claim
31 words
Method according to claim 1, claim 2 or claim 3 wherein the glycosaminoglycan is present in the suspension at a concentration of from about 100 to about 1000 micrograms per milliliter.
Claim 20
Dependent Claim
27 words
Method according to any one of the preceding claims wherein the ratio of the concentration of collagen to the concentration of glycosaminoglycan is about 25-35 to 1.
Claim 21
Dependent Claim
18 words
Method according to claim 5 wherein the glycosaminoglycan or one of the glycosaminoglycans is heparin or heparin sulfate.
Claim 22
Dependent Claim
16 words
Method according to claim 5 wherein the glycosaminoglycan or one of the glycosaminoglycans is an alginate.
Claim 23
Dependent Claim
21 words
A composition consisting essentially of a major amount of collagen in admixture with a minor amount of heparin and/or of alginate.
Claim 24
Dependent Claim
21 words
A composition consisting essentially of a major amount of collagen in admixture with a minor amount of heparin and/or of alginate.
Claim 25
Dependent Claim
17 words
9 . The composition according to claim 8 wherein the composition is chemotactic for tissue repair cells.
Claim 26
Dependent Claim
32 words
The composition according to claim 9 wherein collagen is present at about 7-10 milligrams per milliliter and the heparin or alginate or mixture thereof is present at about 250-350 micrograms per milliliter.
References Cited (Backward Citations)
No citation records indexed.
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