EP0153641A2
Expired / Lapsed
EP
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Ion test means having a porous carrier matrix
Assignee: Bayer Corp
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Filing: 1985-02-11
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Granted: —
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Expires: 2005-02-11
Abstract
Abstract The present invention resides in the discovery of a new test means for detecting the presence of an ion in an aqueous test sample and determining its concentration. The test means comprises a porous carrier matrix substantially uniformly incorporated with a) a homogeneous hydrophobic mixture containing three principal ingredients: an ionophore capable of forming a complex with the ion, a hydrophobic vehicle, and a reporter substance capable of interacting with the complex of ionophore and ion to produce a detectable response; and b) a buffering substance capable of providing a pH In the range of from about 5 to 10. A test device comprises the test means affixed to one upper flat face of an elongated support member. In use, the aqueous test sample is contacted with the test means or device. The presence and/or concentration of the ion in the test sample is then determined by observing any detectable response produced. The test means and device of the present invention provide rapid results, sufficient detectable response forming In most instances in at least a few minutes.
Inventors
- 👤 Mary Lou Gantzer
- 👤 Paul R. Hemmes Jr.
- 👤 Daniel Wong
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 14:38
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/84; G01N33/52; G01N33/521
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
85 words
A test means for determining the presence of an ion in an aqueous test sample, the test means comprising a porous carrier matrix substantially uniformly incorporated with a) a homogeneous hydrophobic composition containing an ionophore capable of forming a complex with the ion, a hydrophobic vehicle, and a reporter substance capable of interacting with the complex of the ionophore and ion to produce a detectable response; and b) a buffering substance capable of providing a pH in the range of from about 5 to 10.
Claim 2
Dependent Claim
85 words
A test means for determining the presence of an ion in an aqueous test sample, the test means comprising a porous carrier matrix substantially uniformly incorporated with a) a homogeneous hydrophobic composition containing an ionophore capable of forming a complex with the ion, a hydrophobic vehicle, and a reporter substance capable of interacting with the complex of the ionophore and ion to produce a detectable response; and b) a buffering substance capable of providing a pH in the range of from about 5 to 10.
Claim 3
Dependent Claim
14 words
The test means of Claim 1 in which the porous carrier matrix is paper.
Claim 4
Dependent Claim
16 words
The test means of Claim 1 or 2 in which the ionophore is an uncharged podand.
Claim 5
Dependent Claim
22 words
The test means of any one of Claims 1 to 3 in which the homogeneous hydrophobic composition additionally contains a hydrophobic polymer.
Claim 6
Dependent Claim
29 words
The test means of any one of Claims 1 to 4 in which the porous carrier matrix is additionally incorporated. with a wetting substance and/or an interferent removal system.
Claim 7
Dependent Claim
42 words
The test means of any one of Claims 1 to 5 in which the reporter substance is one capable of producing the appearance of, or change in, color or fluorescence in the presence of the complex of the ionophore and ion. ,
Claim 8
Dependent Claim
97 words
The test means of any one of Claims 1 to 6 in which the reporter substance is a compound having the structure in which X is a halogen or pseudohalogen; in which each R , same or different, is a 2-, 3-, 5-, and/or 6-position substituent selected from lower alkyl, intermediate alkyl, aryl and a fused ring at the 2,3- or 5,6- positions; and n is 0 to 4; or the structure in which R' is H or lower alkyl, preferably methyl, R * is H or intermediate alkyl, preferably n-decyl, and X is halogen or pseudohalogen.
Claim 9
Independent Claim
154 words
A method for preparing a test means for determining the presence of an ion in an aqueous test sample, the method comprising the steps of a) forming a homogeneous first mixture of the hydrophobic composition comprising an ionophore capable of forming a complex with the ion, a hydrophobic vehicle, a reporter substance capable of interacting with the complex of the ionophore and the ion to produce a detectable response and an organic solvent; b) forming a homogeneous second mixture of a buffering substance capable of providing a pH in the range of from about5 to 10 and water or a water-miscible solvent or mixtures thereof; c) incorporating one of the first or the second mixtures with a porous carrier matrix; d) drying the incorporated matrix; e) incorporating the other of the first or second mixtures with the porous rarrier matrix to form a doubly incorporated matrix; and f) drying the doubly incorporated carrier matrix.
Claim 10
Independent Claim
154 words
A method for preparing a test means for determining the presence of an ion in an aqueous test sample, the method comprising the steps of a) forming a homogeneous first mixture of the hydrophobic composition comprising an ionophore capable of forming a complex with the ion, a hydrophobic vehicle, a reporter substance capable of interacting with the complex of the ionophore and the ion to produce a detectable response and an organic solvent; b) forming a homogeneous second mixture of a buffering substance capable of providing a pH in the range of from about5 to 10 and water or a water-miscible solvent or mixtures thereof; c) incorporating one of the first or the second mixtures with a porous carrier matrix; d) drying the incorporated matrix; e) incorporating the other of the first or second mixtures with the porous rarrier matrix to form a doubly incorporated matrix; and f) drying the doubly incorporated carrier matrix.
Claim 11
Dependent Claim
15 words
The method of Claim 8 in which the first mixture additionally contains a hydrophobic polymer.
Claim 12
Independent Claim
22 words
The method of Claims 8 or 9 in which the second mixture additionally contains a wetting substance and/or an interferant removal systemn.
Claim 13
Dependent Claim
38 words
A process for determining the presence of an ion in an aqueous test sample, the process comprising contacting the test sample with the test means of any one of Claims 1 to 7 and observing a detectable response.
References Cited (Backward Citations)
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