New renin-inhibitory peptides and their use

Claim 1

Compounds of formula (I): [wherein: R 1 represents a C 1 -C 4 alkyl group having: (a) an amino or protected amino substituent on its a-carbon atom and (b) a carbocyclic aromatic substituent, a heterocyclic substituent or a heterocyclic-dithio substituent wherein the aromatic or heterocyclic ring is unsubstituted or has at least one amino, alkyl, hydroxy, alkoxy, halogen, nitro, mercapto or alkylthio substituent; R 2 represents a hydrogen atom, a C 1 -C 18 alkyl group, a C 2 -C 5 alkenyl group, a C 2 -C 5 alkenyl group having at least one halogen substituent, a C 2 -C 5 alkynyl group, a C 3 -C 7 cycloalkyl group, a C 5 -C 8 cycloalkenyl group, or a C 1 -C 4 alkyl group having one substituent selected from: ( c ) C3 - C7 cycloalkyl groups, C 5 - C 8 cycloalkenyl groups, aryl groups and 5- and 6-membered heterocyclic groups having at least one sulphur, nitrogen or oxygen hetero-atom and optionally at least one substituent selected from: (d) halogen atoms, hydroxy groups, alkoxy groups, aryloxy groups, aralkyloxy groups, aliphatic carboxylic acyloxy groups, mercapto groups, alkylthio groups, aliphatic carboxylic acylaminoalkylthio groups, arylthio groups, aralkylthio groups, alkylsulphinyl groups, alkylsulphonyl groups, arylsulphinyl groups, arylsulphonyl groups, amino groups, mono- and di- alkylamino groups, arylamino groups. aliphatic carboxylic acylamino groups, aromatic carboxylic acylamino groups, alkoxycarbonylamino groups, aralkyloxycarbonylamino groups, aliphatic carboxylic acyl groups, aromatic carboxylic acyl grougs carboxy groups, alkoxycarbonyl groups, aralkyloxycarbonyl groups, carbamoyl groups, mono-and di- alkylcarbamoyl groups, ureido groups, thioureido groups and guanidyl groups; R 3 represents an isobutyl, sec-butyl, benzyl or (C 3 -C 8 cycloalkyl)methyl group; X represents a group of formula -CH(-A-R 4 )-Y (in which: A represents a single bond or an alkylene group; R 4 represents a carboxy group; a protected carboxy group, a carbamoyl group, an N-substituted carbamoyl group, a carbazoyl group, an N-substituted carbazoyl group or an acyl group; and Y represents a hydroxy group, a mercapto group or a formyl group), or a group of formula -P(O)(R 5 )-OH (in which R 5 represents a substituted alkyl group having at least one carboxy, protected carboxy, N-substituted carbamoyl, carbazoyl, N-substituted carbazoyl, C 2 -C 7 aliphatic carboxylic acyl or aromatic carboxylic acyl substituent); provided that, where A represents an alkylene group and R 2 represents a 4-imidazolylmethyl group, R 4 does not represent a carbamoyl group or a formyl group]; and pharmaceutically acceptable salts thereof.