EP0151964A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
New derivatives of alpha-amino-gamma-butyrolactone, method for the preparation thereof and pharmaceutical compositions containing them
Assignee: Laboratorio Farmaceutico CT SRL
•
Filing: 1985-01-20
•
Granted: —
•
Expires: 2005-01-20
Abstract
Abstract The present invention relates to new derivatives of α-amino-γ-butyrolactone and their pharmaceutically acceptable salts, endowed with anti-convulsant, anti-epileptic, sedative action and able to inhibit the ingestion of alcohol and intoxicating drinks. The invention relates also to the method for preparing the derivatives of the invention as well as the pharmaceutical compositions containing them.
Inventors
- 👤 Pietro Tomaso Tessitore
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-08 13:30
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/02; C07D307/26; C07D307/30; C07D307/32; C07D307/33
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
94 words
Derivatives of α-amino-γ-butyrolactone endowed with anti-convulsant, anti-epileptic, sedative action and useful for inhibit ing ingestion of alcohol and intoxicating drinks, comprised in the general formula (I): ( wherein R is a linear or branched alkyl radical containing from 4 to 8 carbon atoms; or R is -OR', R' being a linear or branched alkyl radical containing from 1 to 5 C; n is always zero when R is alkyl, or n is an integer different from zero and comprised bet - ween 1 and 5 when R is -OR') and their pharmaceutically acceptable salts.
Claim 2
Dependent Claim
94 words
Derivatives of α-amino-γ-butyrolactone endowed with anti-convulsant, anti-epileptic, sedative action and useful for inhibit ing ingestion of alcohol and intoxicating drinks, comprised in the general formula (I): ( wherein R is a linear or branched alkyl radical containing from 4 to 8 carbon atoms; or R is -OR', R' being a linear or branched alkyl radical containing from 1 to 5 C; n is always zero when R is alkyl, or n is an integer different from zero and comprised bet - ween 1 and 5 when R is -OR') and their pharmaceutically acceptable salts.
Claim 3
Dependent Claim
1 words
α-n-butylcarbonyl-amino-γ-butyrolactone
Claim 4
Dependent Claim
1 words
α-n-butylcarbonyl-amino-γ-butyrolactone
Claim 5
Dependent Claim
1 words
α-isobutylcarbonyl-amino-γ-butyrolactone
Claim 6
Dependent Claim
1 words
α-isobutylcarbonyl-amino-γ-butyrolactone
Claim 7
Dependent Claim
2 words
. α-pentylcarbonyl-amino-γ-butyrolactone
Claim 8
Dependent Claim
2 words
. α-pentylcarbonyl-amino-γ-butyrolactone
Claim 9
Dependent Claim
2 words
The compound
Claim 10
Dependent Claim
2 words
The compound
Claim 11
Dependent Claim
61 words
6: Method for the preparation of the compounds of the general formula (I) wherein R is a linear or branched alkyl radical contain ing from 4 to 8 C, and n is zero, characterized by the fact that the corresponding acid chloride is allowed to react with the selec ted α-amino-γ-butyrolactone, at reduced temperatures, in the presence of an organic base.
Claim 12
Dependent Claim
61 words
6: Method for the preparation of the compounds of the general formula (I) wherein R is a linear or branched alkyl radical contain ing from 4 to 8 C, and n is zero, characterized by the fact that the corresponding acid chloride is allowed to react with the selec ted α-amino-γ-butyrolactone, at reduced temperatures, in the presence of an organic base.
Claim 13
Dependent Claim
55 words
Method for the preparation of the compounds of the general formula (I) wherein R is -OR', R' being a linear or branched alkyl radical containing 1-5 C and n, always different from zero, is an integer from 1 to 5, characterized in that the ester of a ω-aminoacid is allowed to react with the α-halo-γ-butyrolactone.
Claim 14
Dependent Claim
55 words
Method for the preparation of the compounds of the general formula (I) wherein R is -OR', R' being a linear or branched alkyl radical containing 1-5 C and n, always different from zero, is an integer from 1 to 5, characterized in that the ester of a ω-aminoacid is allowed to react with the α-halo-γ-butyrolactone.
Claim 15
Dependent Claim
35 words
Pharmaceutical compositions containing as active ingredient a compound of the general formula (I) ( wherein R and n have the above mentioned meanings), or a pharma= ceutically acceptable salt thereof, together with pharmaceutically acceptable excipients.
Claim 16
Dependent Claim
35 words
Pharmaceutical compositions containing as active ingredient a compound of the general formula (I) ( wherein R and n have the above mentioned meanings), or a pharma= ceutically acceptable salt thereof, together with pharmaceutically acceptable excipients.
Claim 17
Dependent Claim
13 words
Pharmaceutical compositions containing as active ingredient α-n-butylcarbonyl-amino-γ-butyrolactone, together with pharmaceu tically acceptable excipients.
Claim 18
Dependent Claim
13 words
Pharmaceutical compositions containing as active ingredient α-n-butylcarbonyl-amino-γ-butyrolactone, together with pharmaceu tically acceptable excipients.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.