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EP0151689A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Minute ventilation dependent rate responsive pacer

Assignee: SCHIAPPARELLI MEDTRONIC SpA
•
Filing: 1984-10-08
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Granted: —
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Expires: 2004-10-08
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Abstract

Abstract An electronic circuit included in the pacer detects the impedance between two electrodes connected to it and made up by the conducting part of the pacer case (B) and by an auxiliary subcutaneous lead placed in the chest or by an electrode placed on the insulating part (C) of the case itself. The changing geometry of the chest, due to pulmonary ventilation, determines the impedance variations. The electronic circuit, by processing the impedance signal is able to automatically adjust the stimulation rate of the ventricle and/or of the atrium .between minimum and maximum preset values according to the activity levels of the patient. Said electronic circuit comprises a first block (1) made up by a strobed Impedance/Voltage convertor which operates with minimum energy consumption and produces a signal V (Z AB ) proportional to impedance Z AB . A second block (2) performs the measurement of the absolute increase of the signal between one sample and the previous one (ΔZ AB ). This second block is able to detect relatively rapid variations of the input signal such as those due to the strain of the patient's chest and to distinguish them from slow and spurious variations due to several other causes and produces a signal V (AZ AB ) proportional to AZ AB . A third block (3) calculates the mean value or the average of the absolute values of the impedance variations and produces a signal Vm (ΔZ AB ) which changes proportionally to minute ventilation and, therefore, to the physical activity of the patient. Lastly, a fourth block (4), which can be programmed via telemetry link, associates two limit values (Vm1 and Vm2) of said signal Vm (ΔZ AB ) with respectively two f1 and f2 rates of the pacer regulation circuit (5) which determines the operational mode of the pacer itself.

Inventors

  • 👤 Gianni Plicchi
  • 👤 Giancarlo Canducci

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-24 10:29
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/36; A61N1/362; A61N1/365; A61N1/36514; A61N1/36521

Claims Analysis

Total Claims: 11
Claim 1
Independent Claim 59 words
An implantable rate responsive pacer provided with adequate means to drive the stimulation/inhibition rate within limits which are programmable and related to the metabolic demand of the patient and including a measurement circuit which detects a parameter strictly dependent on pulmonary minute ventilation, that is the quantity of air inhaled by the patient in the time unit, e.g. liters/min.
Claim 2
Dependent Claim 59 words
An implantable rate responsive pacer provided with adequate means to drive the stimulation/inhibition rate within limits which are programmable and related to the metabolic demand of the patient and including a measurement circuit which detects a parameter strictly dependent on pulmonary minute ventilation, that is the quantity of air inhaled by the patient in the time unit, e.g. liters/min.
Claim 3
Dependent Claim 38 words
The pacer of claim 1 wherein the circuit detecting the patient's minute ventilation includes means to detect variations in time of the geometry of at least a part of the chest of the patient due to pulmonary ventilation.
Claim 4
Dependent Claim 141 words
The pacer of claim 2 wherein said circuit detecting the patient's chest geometric variations due to minute ventilation includes two electrodes (A and B), one of which (B) preferably corresponds to pacemaker (P) conductive case and the other (A) is subcutaneously positioned at an adequate and non critical distance from (B) or is placed on an insulating part (C) of the pacer case, adequate means being provided to detect with the proper sampling frequency, e.g. approx. 10 Hz, the impedance variations in time between said electrodes and other means being provided to process that signal and to produce another signal proportional to minute ventilation, care being taken that said electrode (A) be placed in any position which guarantees that the physiologic variations are very lightly affected by movements other than respiration, for example by the movement of the patient's upper limbs.
Claim 5
Dependent Claim 144 words
The pacer according to claim 3, wherein the physiologic variable processing and detecting circuit comprises in series: - a strobed Impedance/Voltage convertor (1) characterized by minimum energy consumption and producing a signal V ( ZAB ) which corresponds to the impedance detected between the electrodes (A and B) provided with the pacer; - block (2) calculating the absolute value variations between a pulse and the previous one produced by the previous block and producing a signal V' (ΔZ AB ); - a low-pass filter (3) or similar circuit with a time constant of a few tens of seconds, e.g. approx. 30 sec., designed to produce the mean value or the average of the absolute values of impedance variations and to produce a signal Vm (ΔZ AB ) changing proportionally to the patient's minute ventilation VE and, hence, strictly dependent on the patient's physical activity.
Claim 6
Dependent Claim 108 words
The pacer according to claim 4, means being provided to send the output signal of low-pass filter(3)to a programmable correlator (4) which via telemetry link associates two values (Vml and Vm2) of the filter output, "a priori" programmed or obtained by two different physical activity levels, with two rate values (fl and f2) of the pacer circuit; said rates defining a possible operational mode of the pacer wherein the stimulation/ /inhibition rate and the time relations of the various operational stages which are sent to the last block (5) of any cardiac pacer, both single and double chambered, depend on the output data of the low-pass filter (3).
Claim 7
Dependent Claim 71 words
A minimum energy consumption electronic circuit which detects a parameter proportional to the patient's minute ventilation suitable to operate artificial organs, such as an artificial heart, or, more generally, to realize implantable or portable, therapeutic or diagnostic devices, wherein the circuit detecting the patient's minute ventilation includes means to detect variations in time of the geometry of at least a part of the chest of the patient due to pulmonary ventilation.
Claim 8
Dependent Claim 71 words
A minimum energy consumption electronic circuit which detects a parameter proportional to the patient's minute ventilation suitable to operate artificial organs, such as an artificial heart, or, more generally, to realize implantable or portable, therapeutic or diagnostic devices, wherein the circuit detecting the patient's minute ventilation includes means to detect variations in time of the geometry of at least a part of the chest of the patient due to pulmonary ventilation.
Claim 9
Dependent Claim 147 words
A circuit according to claim 6 detecting the patient's chest geometric variations due to minute ventilation, including two electrodes (A and B), one of which (B) preferably corresponds to the (P) conductive case of the therapeutic or diagnostic device and the other (A) is subcutaneously positioned at an adequate and non critical distance from (B) or is placed on an insulating part (C) of the said case, the adequate means being provided to detect with the proper sampling frequency, e.g. approx. 10 Hz, the impedance variations in time between said electrodes and other means being provided to process that signal and to produce another signal propor= tional to minute ventilation, care being taken that said electrode (A) be placed in any position which guarantees that the physiologic variations are very lightly affected by movements other than respiration, for example by the movement of the patient's upper limbs.
Claim 10
Dependent Claim 139 words
A circuit according to claim 7, comprising in series: - a strobed Impedance/Voltage convertor (1) characterized by minimum energy consumption and producing a signal V (Z AB ) which corresponds to the impedance detected between the electrodes (A and B) provided with the therapeutic or diagnostic device; - block (2) calculating the absolute value variations between a pulse and the previous one produced by the previous block and producing a signal V' (ΔZ AB ); - a low-pass filter (3) or similar circuit with a time constant of a few tens of seconds, e.g. approx. 30 sec., designed to produce the mean value or the average of the absolute values of impedance variations and to produce a signal Vm (ΔZ AB ) changing proportionally to the patient's minute ventilation VE and, hence, strictly dependent on the patient's physical activity.
Claim 11
Dependent Claim 73 words
A circuit according to claim 8 means being provided to send the output signal of low-pass filter (3) to a programmable correlator (4) which via telemetry link associates two values (Vml and Vm2) of the filter output, "a priori" programmed or obtained by two different physical activity levels, with two rate values (fl and f2) of the device circuit; said rates defining a possible operational mode of the said therapeutic or diagnostic device.

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